Bulletproof Vests/shields Prepared From Composite Material Based On Strong Polyamide Fibers And Epoxy Resin

Fiber Reinforced Plastics (FRP) have arisen as a main class of tactual materials having high strength and light weight implemented in a large scale of different applications. This study performs a comparison between the enhanced propidines of Kevlar 49 fiber and Twaron CT 704 reinforced with epoxy resin to obtain an efficient, light weight and slim body m o r capable of resisting high speed projectiles (9 mm bullets). Reinforcing the fabrics adds extra strength to the fabrics instead of using several unreinforced fabrics which increases the weight thickness and the cost of the final product. The response of the prepared composite material based on the two different fibers was studied by using a test barrel for the penetration test. In addition. indentation test is also au lied to compare between the mechanical properties of both laminates and determine which fabric is better for life protection application. The final results showed that using the technique of reinforcing the fabrics specially Twaron is much better where the final bulletproof shield has a smaller number of layers and was found lighter by 40% than those made by Kevlar

Composite Materials Based On Twaron And Nano Materials

This research aims to participate in producing body shield that can overcome pervious drawbacks using behavior of shear thickening fluid. Initially, the rheological behavior of silica-polyethylene glycol shear thickening fluid is examined at different concentrations. Then, ballistic fabric samples are impregnated into silica-polyethylene glycol shear thickening fluid at various concentrations of silica and tested using gas gun simulating real ballistic threat. After that, the impact of rubbery hot water pack filled with around 66.67 wt% starch in water is tested using gas gun. Results showed as the concentration of silica increases, the indentation depth in the impregnated fabric decreases which may result in improving performance of ballistic fabric to 12.5 % in case of using 60 wt% silica, 7.35 % in case of using 30 wt% silica and 3.31 % in case of using 7.5 wt% silica with respect to plain sample. As it showed that no indentation depth is formed in modelling clay when rubbery hot water pack filled with around 66.67 wt% starch in water is tested using gas gun causing improvement percentage to be 100% compared to plain sample of Twaron (CT 714)

The pro-social neurohormone oxytocin reverses the actions of the stress hormone cortisol in human ovarian carcinoma cells in vitro

Copyright: © Mankarious et al. The journey patients with ovarian cancer travel from non-specific symptoms causing delayed diagnosis through surgery and chemotherapy, culminating in a 5-year survival rate of 43%, must have a profound and detrimental psychological impact on patients. Emerging studies link higher levels of oxytocin (OT) and increased social support, an independent prognostic factor in cancer, with a moderating effect on stress. In contrast, there is a known association of tumour cell proliferation with elevated cortisol (stress hormone) levels. We hypothesise therefore that there is cross-talk between cortisol and oxytocin at a molecular level. Three ovarian cancer cell lines, used as in vitro models, were treated with cortisol at concentrations mimicking physiological stress in vivo in the presence or absence of OT. OT reduced cell proliferation and migration, induced apoptosis and autophagy for all three cell lines, partially reversing the effects of cortisol. Quantitative RT-PCR of tissue taken from ovarian cancer patients revealed that the glucocorticoid receptor (splice variant GR-P) and OT receptor (OTR) were significantly upregulated compared to controls. Tissue microarray revealed that the expression of GRα was lower in the ovarian cancer samples compared to normal tissue. OT is also shown to drive alternative splicing of the GR gene and cortisol-induced OTR expression. OT was able to transactivate GR in the presence of cortisol thus providing further evidence of cross-talk in vitro. These data provide explanations for why social support might help distressed ovarian cancer patients and help define novel hypotheses regarding potential therapeutic interventions in socially isolated patients

Shear Thickening Fluids Comparative Analysis Composed of Silica Nanoparticles in Polyethylene Glycol and Starch in Water

Shear thickening fluid (STF) occurs in dispersions of highly condensed colloid particles and is categorized as a non-Newtonian fluid whose viscosity increases under shear loading which makes them beneficial in protective and impact resistance applications. The aim of this study is to synthesis two different STFs and characterize their microstructural properties to provide a data base for comparing the final macrobehavior of the two fluids under mechanical testing. Therefore, fumed silica and polyethylene glycol STF and starch with water STF-based dispersions were prepared. The particle size, zeta potential, SEM micrographs, and rheological analysis were performed for each type of STF. The effect of filler concentration was observed by using 10–30 weight% filling material. The rheological properties of STFs show higher viscosity measurements at same shear rates for starch/water STF than silica/PEG with maximum viscosity reaching 523.6 Pa s and 178.9 Pa s, respectively. Larger starch particle size over silica recorded as 303.7 nm and 16.49 nm, respectively, and zeta potential analysis recorded particle electrostatic charges as 22.6 mV and 12.8 mV, respectively, leading to more dispersion stability and obvious thickening effect at higher particle concentration leading to greater jump in viscosity at sudden shear rate. The results indicate the capability of trying more protective applications with more flexibility and less thickness when STF is implemented and a good database for the fluids to choose from according to their behavior

Microvascular replantation of a traumatically amputated ear

We describe the replantation of a traumatically severed auricle using microvascular anastomosis to reestablish blood flow to the ear. Microvascular reattachment of the severed auricle occurred 10 hours after the trauma. Postoperatively, adjunctive measures, including anticoagulation and the use of medicinal leeches, were used to relieve venous congestion of the replanted auricle. The replanted auricle healed completely with 100% survival, resulting in an essentially normal-appearing external ear. In the management of a traumatically severed auricle, microvascular replantation should be considered as the intervention of first choice in selected cases. If the procedure is successful, the cosmetic results are excellent; if it is not successful, a number of other reconstructive techniques remain as options

Transcriptome Analyses Identify Deregulated <i>MYC</i> in Early Onset Colorectal Cancer

Despite a global decrease in colorectal cancer (CRC) incidence, the prevalence of early-onset colorectal cancer (EOCRC), or those occurring in individuals before the age of 50, has steadily increased over the past several decades. When compared to later onset colorectal cancer (LOCRC) in individuals over 50, our understanding of the genetic and molecular underpinnings of EOCRCs is limited. Here, we conducted transcriptomic analyses of patient-matched normal colonic segments and tumors to identify gene expression programs involved in carcinogenesis. Amongst differentially expressed genes, we found increased expression of the c-MYC proto-oncogene (MYC) and its downstream targets in tumor samples. We identified tumors with high and low differential MYC expression and found patients with high-MYC tumors were older and overweight or obese. We also detected elevated expression of the PVT1 long-non-coding RNA (lncRNA) in most tumors and found gains in copy number for both MYC and PVT1 gene loci in 35% of tumors evaluated. Our transcriptome analyses indicate that EOCRC can be sub-classified into groups based on differential MYC expression and suggest that deregulated MYC contributes to CRCs that develop in younger patients