Sequestering atmospheric CO₂ inorganically:a solution for Malaysia's CO₂ emission

Malaysia is anticipating an increase of 68.86% in CO2 emission in 2020, compared with the 2000 baseline, reaching 285.73 million tonnes. A major contributor to Malaysia's CO2 emissions is coal-fired electricity power plants, responsible for 43.4% of the overall emissions. Malaysia's forest soil offers organic sequestration of 15 tonnes of CO2 ha(-1) year(-1). Unlike organic CO2 sequestration in soil, inorganic sequestration of CO2 through mineral carbonation, once formed, is considered as a permanent sink. Inorganic CO2 sequestration in Malaysia has not been extensively studied, and the country's potential for using the technique for atmospheric CO2 removal is undefined. In addition, Malaysia produces a significant amount of solid waste annually and, of that, demolition concrete waste, basalt quarry fine, and fly and bottom ashes are calcium-rich materials suitable for inorganic CO2 sequestration. This project introduces a potential solution for sequestering atmospheric CO2 inorganically for Malaysia. If lands associated to future developments in Malaysia are designed for inorganic CO2 sequestration using demolition concrete waste, basalt quarry fine, and fly and bottom ashes, 597,465 tonnes of CO2 can be captured annually adding a potential annual economic benefit of (sic)4,700,000.</p

Solid crystal suspension of Efavirenz using hot melt extrusion: exploring the role of crystalline polyols in improving solubility and dissolution rate

The poor aqueous solubility of drugs has emerged as a major issue for pharmaceutical scientists from many decades. The current study explores the manufacture and development of a thermodynamically stabilized solid crystal suspension (SCS) of poorly water soluble drug efavirenz via hot melt extrusion. Efavirenz is a non-nucleoside reverse transcriptase inhibitor and belongs to BCS class II. The SCS was prepared using pearlitol and xylitol as a crystalline carrier. The drug-excipient blend was processed by hot melt extrusion with up to 50% (w/w) drug loading. Physico-chemical characterization of the SCS conducted via a scanning electron microscopy showed crystalline morphology. The solid state analysis undertaken by using differential scanning calorimetry and hot stage microscopy confirmed that SCS are in crystalline state. Similarly, X-ray powder diffraction analysis revealed that pure drug, crystalline carriers and developed SCS are in crystalline state. The FTIR chemical imaging analysis of SCS formulations showed a homogeneous drug distribution within respective crystalline carriers while an advanced chemical analysis via atomic force microscopy and Raman analysis complemented the foregoing findings of the FTIR imaging. The developed SCS1 formulation showed up to 81 fold increase in the solubility and 4.1 fold increase in the dissolution rate of the drug compared to that of the bulk substance. Surprisingly, the developed SCS formulation remained stable for a period of more than one year at accelerated conditions inferred from dissolution studies. It can be concluded that the SCS approach can be used as an alternative contemporary technique to enhance the dissolution rates of many other poorly water-soluble drugs by means of thermal HME processing

Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients

The purpose of this study was to evaluate the performance of Neusilin® (NEU) a synthetic magnesium aluminometasilicate as inorganic drug carrier co-processed with the hydrophilic surfactants Labrasol and Labrafil to develop Tranilast (TLT) based solid dispersions using continuous melt extrusion (HME) processing. Twin – screw extrusion was optimized to develop various TLT/excipient/surfactant formulations followed by continuous capsule filling in the absence of any downstream equipment. Physicochemical characterisation showed the existence of TLT in partially crystalline state in the porous network of inorganic NEU for all extruded formulations. Furthermore, the in line NIR studies revealed a possible intermolecular H–bonding formation between the drug and carrier resulting in the increase of dissolution of TLT. The capsules containing TLT extruded solid dispersions showed enhanced dissolution rates and compared with the marketed Rizaben® product

Effect of moisture damage on gap-graded asphalt mixture incorporating electric arc furnace steel slag and copper mine tailings

Water damage is a vital factor affecting the durability of gap-graded asphalt. There is an urgent need for a pragmatic and reasonable test to evaluate this parameter. Previous research has proposed that tensile strength ratio is a promising test for this application. Therefore, the aim of this paper is to evaluate the effect of moisture damage on gap-graded asphalt mixture incorporating electric arc furnace (EAF) steel slag and copper mine tailings (CMT). Four material mixtures of eight mix designs were investigated. Each mix was conditioned in water for 24-hour and 48-hour before testing. The study adopted retained strength index (RSI), durability index (DI) and tensile strength ratio (TSR) to describe the durability of gap-graded asphalt incorporating EAF steel slag and copper mine tailings. The results reveal that all the mixes fulfill the prescribed criteria. Also, there is a strong correlation between the retained strength index and the durability index with a strong coefficient of determination, R 2 of 0.9543. The results of the study further showed that gap-graded asphalt mixture incorporating EAF steel slag and copper mine tailings did not seem to pose any problem

A quality by design (QbD) twin—screw extrusion wet granulation approach for processing water insoluble drugs

In this study, a Quality by Design (QbD) approach was used to identify the effect of formulation parameters in a twin screw wet extrusion granulation process for the manufacturing of ibuprofen (IBU) granules with increased dissolution rates. A fractional factorial Design of Experiment (DoE) was used to investigate the effect of the excipient composition, binder amount and liquid to solid (L/S) ratio (independent variables) on drug dissolution rates, median particle size diameter and specific surface area (dependent variables). The intra-granular addition of the binder in inorganic/polymer blends processed with ethanol as granulating liquids facilitated the formation of granules at various particle sizes. DoE regression analysis showed that all formulation parameters affect the dependent variables significantly. The enhanced dissolution rates were attributed not only to the IBU particle size reduction and adsorption in the porous inorganic network but also to the high specific surface area of the produced granules. Dynamic vapour sorption showed increased water absorption for granules with small particle size distribution and high specific surface area

Volumetric properties and leaching effect of asphalt mixes with electric arc furnace steel slag and copper mine tailings

This study focuses on the potential of electric arc furnace (EAF) steel slag and copper mine tailings as asphalt paving materials with respect to issues of volumetric properties and leaching. In this study, four different asphalt mixes were investigated; each contained EAF steel slag and copper mine tailings of various proportions. Apart from the microstructure analysis of the materials, a toxicity characteristics leaching procedure (TCLP) test was conducted on both the mixes and the aggregates. All the mixes were evaluated by the following parameters: Voids in the mineral aggregates (VMA), voids in total mix (VTM), voids filled with asphalt (VFA), Marshall stability and flow and specific gravity. F-test ANNOVA was used to evaluate the degree of significance of the mixes with each of the evaluated standards. It was observed that the mixes containing either EAF steel slag or copper mine tailings or both gave better results than the control mix. In terms of the TCLP test, none of the detected hazardous elements exceeded the standard limits, which indicates the possibility of using them as construction materials

Chemical and biological investigations of Delonix regia (Bojer ex Hook.) Raf.

U radu je opisana izolacija pet sastojaka petroleterske i diklormetanske frakcije metanolnog ekstrakta kore biljke Delonix regia: lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) i p-metoksibenzaldehid (5). Nadalje, testirano je antimikrobno djelovanje različitih ekstrakata difuzijskom metodom na disku (15 μg mm2). Zone inhibicije za sastojke topljive u petroleteru, tetraklormetanu i diklormetanu bile su 914 mm, 1113 mm, odnosno 920 mm, dok je zona inhibicije standarda kanamicina bila 2025 mm. U biološkom pokusu smrtnosti morskih kozica najveću toksičnost pokazali su spojevi topljivi u tetraklormetanu (LC50 = 0,83 μg mL1), dok je topljivost sastojaka topljivih u petroleteru i diklormetanu bila LC50 14,94, odnosno 3,29 μg mL1, a standarda vinkristin sulfata 0,812 μg mL1. Ovo je prvo izvješće o izolaciji sastojaka, antimikrobnom djelovanju i citotoksičnosti biljke D. regia.In this study five compounds, lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) and p-methoxybenzaldehyde (5) were isolated from the petroleum ether and dichloromethane fractions of a methanolic extract of the stem bark of Delonix regia. Antimicrobial screening of the different extracts (15 μg mm2) was conducted by disc diffusion method. The zones of inhibition demonstrated by the petroleum ether, carbon tetrachloride and dichloromethane fractions ranged from 914 mm, 1113 mm and 920 mm, respectively, compared to kanamycin standard with the zone of inhibition of 2025 mm. In brine shrimp lethality bioassay, the carbon tetrachloride soluble materials demonstrated the highest toxicity with LC50 of 0.83 μg mL1, while petroleum ether and dichloromethane soluble partitionates of the methanolic extract revealed LC50 of 14.94 and 3.29 μg mL1, respectively, in comparison with standard vincristine sulphate with LC50 of 0.812 μg mL1. This is the first report on compounds separation from D. regia, their antimicrobial activity and cytotoxicity

Recent advances on palm oil mill effluent (POME) pretreatment and anaerobic reactor for sustainable biogas production

Palm oil is one of the leading agricultural crops in the world, as it dominates 34% of the global vegetable oil market, with approximately 64.6*103 million kgs of production in 2017. However, along with its breakthrough, the generation of palm oil mill effluent (POME) as uncontrolled waste has become a serious matter and requires proper management to reduce its negative effects on the environment. Subsequently, the high organic content of POME makes it possible to convert waste into value-added products, such as biogas. A ratio of 0.5 for biological oxygen demand to chemical oxygen demand (BOD/COD) indicates a high possibility for biological treatment. Recently, the utilisation of POME as a cheap source for biogas production has gained an extraordinary amount of attention, and intensive research has been conducted on the upstream to downstream process. Finding the most suitable and efficient pretreatment technique and reactor configuration are vital parameters for the treatment and conversion of POME to biogas. This review describes existing pretreatment processes for POME and recommends recently manufactured high-rate anaerobic reactors as the most suitable and efficient pretreatment technique for maximising the extraction of biogas from POME

Properties of asphaltic concrete containing sasobit®

With increasing interest in the use of hot mix asphalt in the paving industry, more studies in this field for improvement of hot mix asphalt properties seem to be necessary. Hence, the main objective of this study was to investigate the effect of sasobit® content as modified binder in hot mix asphalt. 60/70 penetration grade asphalt was separately modified with sasobit® at different concentrations ranging from 0% to 4.5%. The influence of sasobit® on the hot mix asphalt mixtures properties were detected through conventional tests i.e. penetration and softening point. In addition, the Marshall stability, abrasion loss, and resilient modulus were also examined. Results indicated that the hot mix asphalt containing Sasobit® additive has significant affect in terms of penetration and softening point. Furthermore, the addition of Sasobit® seemed to improve the stability, abrasion loss and modulus of stiffness