A christian inscription of Peñaflor (Seville, Spain)

Un nuevo epígrafe descubierto en Peñaflor, la antigua Celti, no es sólo un valioso testimonio del hábito epigráfico tardoantiguo en la margen derecha de la Vega del Guadalquivir, al oeste de Hispalis; también lo es del uso de la expresión servus dei, apenas utilizada en la epigrafía de Hispania.A new inscription found at Peñaflor (ancient Celti) provides valuable evidence for the epigraphic habit in Late Antiquity in the area of the Vega del Guadalquivir north of the river to the east of Seville; it also provides proof of the use of the expression servus dei, rarely found in the early Christian epigraphy of the Iberian Peninsula

CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation.

To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the endogenous mouse Card14 locus. Heterozygous expression of CARD14E138A rapidly induced skin acanthosis, immune cell infiltration and expression of psoriasis-associated pro-inflammatory genes. Homozygous expression of CARD14E138A induced more extensive skin inflammation and a severe systemic disease involving infiltration of myeloid cells in multiple organs, temperature reduction, weight loss and organ failure. This severe phenotype resembled acute exacerbations of generalised pustular psoriasis (GPP), a rare form of psoriasis that can be caused by CARD14 mutations in patients. CARD14E138A-induced skin inflammation and systemic disease were independent of adaptive immune cells, ameliorated by blocking TNF and induced by CARD14E138A signalling only in keratinocytes. These results suggest that anti-inflammatory therapies specifically targeting keratinocytes, rather than systemic biologicals, might be effective for GPP treatment early in disease progression

‘Dans les pierres, il ne peut y avoir de fiction’ ?

International audienceRodrigo Caro (1573-1647) has long been considered an unreliable witness of the epigraphic tradition, first and foremost by E. Hübner (CIL II). This article reconsiders his role in the transmission of the Conventus Hispalensis' falsae vel incertae, after a careful analysis of Caro's Antigüedades de Sevilla (1634). Within this work, the Sevillian humanist overall appears to be scrupulous: it is only his duty to superior interests, such as those of the archbishopric of Seville, which forces him (as in his defense of the pseudo-Dexter) to reluctantly retain certain falsae included in the Antigüedades

Lineamenti per una storia della critica della falsificazione epigrafica

This article offers the first comprehensive investigation of the history of scholarship related to epigraphic forgeries. Fake inscriptions were already produced in Antiquity and throughout the Middle Ages, but their number began to rise dramatically from the Renaissance onwards. By the mid-1500s, scholars became attentive of the risks of using fake sources for antiquarian purposes, while in the 17th and 18th centuries they started isolating forged or suspect texts within specific sections of their new epigraphic corpora. Tentative sets of criteria for isolating non-genuine inscriptions were first identified by Scipione Maffei around 1720, but an actual epistemology for epigraphic criticism was only developed by Theodor Mommsen and his collaborators in the mid-1800s. Since then, most corpora and critical editions have, often implicitly, followed their scientific principles. Current scholars should be well aware of them, because they can present both considerable rewards and serious shortcomings

Antiquarianism

The aim of this entry is to provide a definition for Renaissance antiquarianism as a cultural phenomenon that influenced the way the past was interpreted between the fourteenth and seventeenth centuries. This cultural pathway represented a methodological perspective which involved the cross-referencing of heterogeneous sources, strongly linked to mankind’s perception of time, and which helped to shape historical consciousness. The focus then turns to the history of the phenomenon and an explanation of its methodology