Towards testing a two-Higgs-doublet model with maximal CP symmetry at the LHC: construction of a Monte Carlo event generator

A Monte Carlo event generator is constructed for a two-Higgs-doublet model with maximal CP symmetry, the MCPM. The model contains five physical Higgs bosons; the $\rho'$, behaving similarly to the standard-model Higgs boson, two extra neutral bosons $h'$ and $h"$, and a charged pair $H^\pm$. The special feature of the MCPM is that, concerning the Yukawa couplings, the bosons $h'$, $h"$ and $H^\pm$ couple directly only to the second generation fermions but with strengths given by the third-generation-fermion masses. Our event generator allows the simulation of the Drell-Yan-type production processes of $h'$, $h"$ and $H^\pm$ in proton-proton collisions at LHC energies. Also the subsequent leptonic decays of these bosons into the $\mu^+ \mu^-$, $\mu^+ \nu_\mu$ and $\mu^- \bar \nu_\mu$ channels are studied as well as the dominant background processes. We estimate the integrated luminosities needed in $p p$ collisions at center-of-mass energies of 8 TeV and 14 TeV for significant observations of the Higgs bosons $h'$, $h"$ and $H^\pm$ in these muonic channels

Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts

The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 ± 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA

Minimizing Higgs Potentials via Numerical Polynomial Homotopy Continuation

The study of models with extended Higgs sectors requires to minimize the corresponding Higgs potentials, which is in general very difficult. Here, we apply a recently developed method, called numerical polynomial homotopy continuation (NPHC), which guarantees to find all the stationary points of the Higgs potentials with polynomial-like nonlinearity. The detection of all stationary points reveals the structure of the potential with maxima, metastable minima, saddle points besides the global minimum. We apply the NPHC method to the most general Higgs potential having two complex Higgs-boson doublets and up to five real Higgs-boson singlets. Moreover the method is applicable to even more involved potentials. Hence the NPHC method allows to go far beyond the limits of the Gr\"obner basis approach.Comment: 9 pages, 4 figure

Inertial drag and lift forces for coarse grains on rough alluvial beds measured using in-grain accelerometers

Quantifying the force regime that controls the movement of a single grain during fluvial transport has historically proven to be difficult. Inertial micro-electromechanical system (MEMS) sensors (sensor assemblies that mainly comprise micro-accelerometers and gyroscopes) can used to address this problem using a “smart pebble”: a mobile inertial measurement unit (IMU) enclosed in a stone-like assembly that can measure directly the forces on a particle during sediment transport. Previous research has demonstrated that measurements using MEMS sensors can be used to calculate the dynamics of single grains over short time periods, despite limitations in the accuracy of the MEMS sensors that have been used to date. This paper develops a theoretical framework for calculating drag and lift forces on grains based on IMU measurements. IMUs were embedded a spherical and an ellipsoidal grain and used in flume experiments in which flow was increased until the grain moved. Acceleration measurements along three orthogonal directions were then processed to calculate the threshold force for entrainment, resulting in a statistical approximation of inertial impulse thresholds for both the lift and drag components of grain inertial dynamics. The ellipsoid IMU was also deployed in a series of experiments in a steep stream (Erlenbach, Switzerland). The inertial dynamics from both sets of experiments provide direct measurement of the resultant forces on sediment particles during transport, which quantifies (a) the effect of grain shape and (b) the effect of varied-intensity hydraulic forcing on the motion of coarse sediment grains during bedload transport. Lift impulses exert a significant control on the motion of the ellipsoid across hydraulic regimes, despite the occurrence of higher-magnitude and longer-duration drag impulses. The first-order statistical generalisation of the results suggests that the kinetics of the ellipsoid are characterised by low- or no-mobility states and that the majority of mobility states are controlled by lift impulses

Cloning and sequence analysis of cDNAs encoding the cytosolic precursors of subunits GapA and GapB of chloroplast glyceraldehyde-3-phosphate dehydrogenase from pea and spinach

Chloroplast glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is composed of two different subunits, GapA and GapB. cDNA clones containing the entire coding sequences of the cytosolic precursors for GapA from pea and for GapB from pea and spinach have been identified, sequenced and the derived amino acid sequences have been compared to the corresponding sequences from tobacco, maize and mustard. These comparisons show that GapB differs from GapA in about 20% of its amino acid residues and by the presence of a flexible and negatively charged C-terminal extension, possibly responsible for the observed association of the enzyme with chloroplast envelopes in vitro. This C-terminal extension (29 or 30 residues) may be susceptible to proteolytic cleavage thereby leading to a conversion of chloroplast GAPDH isoenzyme I into isoenzyme II. Evolutionary rate comparisons at the amino acid sequence level show that chloroplast GapA and GapB evolve roughly two-fold slower than their cytosolic counterpart GapC. GapA and GapB transit peptides evolve about 10 times faster than the corresponding mature subunits. They are relatively long (68 and 83 residues for pea GapA and spinach GapB respectively) and share a similar amino acid framework with other chloroplast transit peptides

The hazards of genotype imputation in chromosomal regions under selection: A case study using the Lactase gene region

Although imputation of missing SNP results has been widely used in genetic studies, claims about the quality and usefulness of imputation have outnumbered the few studies that have questioned its limitations. But it is becoming clear that these limitations are real—for example, disease association signals can be missed in regions of LD breakdown. Here, as a case study, using the chromosomal region of the well-known lactase gene, LCT, we address the issue of imputation in the context of variants that have become frequent in a limited number of modern population groups only recently, due to selection. We study SNPs in a 500 bp region covering the enhancer of LCT, and compare imputed genotypes with directly genotyped data. We examine the haplotype pairs of all individuals with discrepant and missing genotypes. We highlight the nonrandom nature of the allelic errors and show that most incorrect imputations and missing data result from long haplotypes that are evolutionarily closely related to those carrying the derived alleles, while some relate to rare and recombinant haplotypes. We conclude that bias of incorrectly imputed and missing genotypes can decrease the accuracy of imputed results substantially

Determining the global minimum of Higgs potentials via Groebner bases - applied to the NMSSM

Determining the global minimum of Higgs potentials with several Higgs fields like the next-to-minimal supersymmetric extension of the Standard Model (NMSSM) is a non-trivial task already at the tree level. The global minimum of a Higgs potential can be found from the set of all its stationary points defined by a multivariate polynomial system of equations. We introduce here the algebraic Groebner basis approach to solve this system of equations. We apply the method to the NMSSM with CP conserving as well as CP violating parameters. The results reveal an interesting stationary-point structure of the potential. Requiring the global minimum to give the electroweak symmetry breaking observed in Nature excludes large parts of the parameter space.Comment: 10 pages, 2 figure