New method in the age estimation by the spheno-occipital suture. 3D cone-beam CT application

The aim of the present study was to determine the sequence and timing of closure of the spheno-occipital synchondrosis for a large sample of a modern Italian population to assess if this age marker is a useful tool for age estimation for individuals. The sample consisted of 494 individuals in the age range 0-22 years, who were admitted to the Department of Radiology, Oncology and Anatomo-Pathology of "Sapienza" University of Rome - UOC Head and Neck Radiology - and the Department of imaging, University of L'Aquila, and who had undergone multi-slice CBCT imaging. The average age of the spheno-occipital closure in men is 18.3 years, whilst in women is 16.6. Therefore, it is evident that the closure in female people is faster than 1.7 years. The timing of closure of spheno-occipital suture can be used to understand the age, even if the research has to be implemented

Cognitive Mechanisms Behind the Memory-Undermining Effect of Feigned Crime-Related Amnesia

Oftentimes individuals charged with severe crimes, such as homicide, claim memory loss for their criminal experience (i.e., crime-related amnesia). However, the act of feigning amnesia negatively affects defendants’ genuine memory when they try to remember what they have committed. This dissertation examines the consequences for memory when individuals feign crime-related amnesia, in order to understand and explain why and how this phenomenon occurs. Overall, the most important finding of this dissertation yielded that although, to some extent, inhibition-based mechanism might explain simulators’ impaired recollection; genuine memory for a crime in general remains uncompromised despite a previously feigned amnesia claim

Mapping Connections between Neighborhoods in Response to Community-Based Social Needs

Geographic proximity might not be the only factor influencing the connections between neighborhoods within the same city. Most likely, the community's needs and behaviors play a role in facilitating or hindering any connections between these urban areas. Accordingly, relationships between communities may differ or be similar based on their respective characteristics. This paper aims to demonstrate that communities are close based on the needs they share, regardless of their ethnicity or geographic location. In this study, a time series analysis of neighborhoods' needs is explored to gain a deeper understanding of the communities' network. The study takes into account the co-occurrence of complaints/reports from residents regarding the same issue. The dataset was retrieved from the Boston Area Research Initiative (BARI) and the 311 system that describe the features of neighborhoods regarding non-emergency issues. Subsequently, the connection between neighborhoods in the City of Boston was analyzed using a mixture of PCA, K-means, association rule mining, and a network creation tool. Moreover, clustering coefficients and degrees of centrality were used as significant factors in identifying the members of groups and marking crucial nodes in the network. A series of graphs were generated to show how the neighborhoods are linked based on their socioeconomic concerns. The results prove that even geographically disconnected neighborhoods within Boston have similar social needs, despite their distance from one another. Furthermore, it revealed that some neighborhoods can act as linking bridges for other neighborhoods, while others may be isolated within the network graph. This study has increased awareness of urban aspects. The authorities may consider other dimensions than the traditional ones regarding neighborhood development and addressing problems. Finally, it helps to identify common characteristics between neighborhoods, which facilitates the policy making process

An experimental investigation of the misinformation effect in crime-related amnesia claims

Research suggests that both internal (i.e., lying) and external (i.e., misinformation) factors can affect memory for a crime. We aimed to explore the effects of post-event misinformation on crime-related amnesia claims. We showed participants a mock crime and asked them to either simulate amnesia (simulators) or confess to it (confessors). Next, some participants were provided with misinformation. Finally, all participants were requested to genuinely recollect the crime. Overall, simulators reported less correct information than confessors. Moreover, these two groups were equally vulnerable to misinformation. In addition, exploratory analyses on strategies adopted by simulators revealed that those who previously, mostly omitted information while simulating amnesia exhibited the lowest amount of correct details. Simulators who instead used a mixed strategy disclosed more fabricated memory errors. Findings suggest that legal professionals and jurors should take into account that even offenders, irrespective of confessing or simulating memory loss for a crime, can be susceptible to post-event misinformation

Retrieval-Induced Forgetting in the Feigning Amnesia for a Crime Paradigm

Previous studies demonstrated that, when asked to honestly provide information about a mock crime, former feigners performed worse than those who were requested to confess to this event. Thus, feigning amnesia for a mock crime undermined genuine memory for the same experience. In the present study, we examined whether retrieval-induced forgetting (RIF) underlies this memory-undermining effect. After watching a mock crime, participants had to feign amnesia or confess to having committed that crime. Feigners were given retrieval practice instructions (i.e., retrieval-practice group) or no further instructions (i.e., control group). Immediately and 1 day later, all participants had to genuinely report what they remembered about the crime. Although simulators in the retrieval-practice group recalled the largest amount of information as a positive consequence of retrieval, the ratio for crucial crime-related details was lower than that exhibited by both simulators who were given no instructions and confessors. These findings suggest that RIF might play a role in forgetting critical information in claims of crime-related amnesia. Theoretical and practical implications will be discussed

Chronic kidney disease and urological disorders: systematic use of uroflowmetry in nephropathic patients

Background. Chronic kidney disease (CKD) is a highly prevalent condition. Urologic disorders are known causes of CKD, but often remain undiagnosed and underestimated also for their insidious onset and slow progression. We aimed to evaluate the prevalence of urological unrecognized diseases in CKD patients by uroflowmetry. Methods. We enrolled consecutive stable CKD outpatients. The patients carried out two questionnaires, the International Prostate Symptom Score and Incontinence Questionnaire-Short Form, and they also underwent uroflowmetry, evaluating max flow rate (Qmax), voiding time and voided volume values. Results. A total of 83 patients (43 males, mean age of 59.8613.3 years) were enrolled. Our study showed 28 males and 10 females with a significant reduction of Qmax (P<0.001) while 21 females reported a significant increase of Qmax (P<0.001) with a prevalence of 49.5% of functional urological disease. Moreover, we showed a significant association between Qmax and creatinine (P¼0.013), estimated glomerular filtration rate (P¼0.029) and voiding volume (P¼0.05). We have not shown significant associations with age (P¼0.215), body mass index (P¼0.793), systolic blood pressure (P¼0.642) or diastolic blood pressure (P¼0.305). Moreover, Pearson’s chi-squared test showed a significant association between Qmax altered with CKD (v2 ¼1.885, P¼0.170) and recurrent infection (v2¼8.886, P¼0.012), while we have not shown an association with proteinuria (v2¼0.484, P¼0.785), diabetes (v2¼0.334, P¼0.563) or hypertension (v2¼1.885, P¼0.170).Conclusions. We showed an elevated prevalence of urological diseases in nephropathic patients; therefore, we suggest to include uroflowmetry in CKD patient assessment, considering the non-invasiveness, repeatability and low cost of examination. Uroflowmetry could be used to identify previously unrecognized urological diseases, which may prevent the onset of CKD or progression to end-stage renal disease and reduce the costs of management

Death connected to paralytic ileus due to the intake of antipsychotic drugs. Case report

Abstract: The aim of this article is to enlarge furtherly the case-studies on the potentially lethal side-effects of second generation atypical antipsychotic drugs. We report the case of a 40-years-old man, under treatment with quietiapine and clozapine because of a psychotic upset, presenting persistent constipation, who died few hours after his arrive at the ER. The autopsy, together with toxicological an histologic exams, allowed to hail the cause of the death from a cardiac upset, fostered by hydroelectric imbalance connected to the sub-occlusion context. This evaluation has been related to the side-effects of these drugs -even if used with therapeutic dosages -that are able to cause in predisposed people, the onset of disorder within the cardiac rhythm, provoking ventricular fibrillation and death. Because of this reason, a constant patients&apos; monitoring -from the first treatment administration through all the therapy -is beneficial, to prevent the onset of these potential lethal episodes

The Impact of False Denials on Forgetting and False Memory

People sometimes falsely deny having experienced an event. In the current experiments, we examined the effect of false denials on forgetting and false memory formation. In Experiment 1, participants were presented with emotionally-negative and neutral associatively related word lists known to engender false memories. After encoding, half of the participants had to falsely deny having seen the words while the other half had to tell the truth. During a final memory test (recall or source monitoring task), participants who falsely denied forgot that they discussed certain words with an experimenter. Furthermore, the act of falsely denying reduced the formation of false memories. These results were partially replicated in Experiment 2 where participants also had to re-learn several words and received a second memory task. This latter design feature diminished the effect of false denials on false memory creation. Our experiments suggest that false denials not only have negative consequences (forgetting), but can have positive ones too (reduction in false memories)

reduction in heart rate variability in autosomal dominant polycystic kidney disease

Introduction: Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Autonomic dysfunction is associated with an increased risk for all cardiovascular events in the general population and can be evaluated with heart rate variability (HRV). Objective: To evaluate HRV in ADPKD patients with mild hypertension versus hypertensive patients with organ damage and healthy controls (HC). Materials and Methods: We have enrolled 65 patients: 21 ADPKD patients (10 males), 20 patients with hypertension (14 males), and 24 HC (10 males). Biochemical analysis, clinical evaluation, anthropometric data, intima-media thickness, 24-h ECG Holter recording, and echocardiography were investigated at the time of enrollment. Results: No significant differences in HRV parameters were found between ADPKD with mild hypertension and hypertensive patients with organ damage. The median of HRV variables in time domain as SDNN (global autonomic activity) was significantly lower in ADPKD and hypertensive patients than HC (p < 0.05). In the frequency domain analysis, low frequency (LF), which mainly reflects the sympathetic component, showed higher values in ADPKD and hypertensive patients than HC during the night (p < 0.01). During the night, the sympathovagal balance, LF/high frequency (HF), showed higher values in ADPKD and hypertensive patients than HC (p < 0.0001). Conversely, LF day was lower in ADPKD and hypertensive patients than HC (p < 0.01). HF, which mainly reflects the parasympathetic component, was lower in ADPKD and hypertensive patients during the night than HC (p < 0.0001). Conclusions: HRV reduction is present in ADPKD patients with mild hypertension in the absence of organ damage. The evaluation of sympathovagal balance can provide novel information on the cardiovascular risk in ADPKD patients in addition to classical risk factors

Crime-Related Scenarios Do not Lead to Superior Memory Performance in the Survival Processing Paradigm

The survival processing advantage refers to the finding that processing information according to its survival value improves memory retention. We used mass-testing across three experiments to examine whether the survival processing advantage could be extended to crime-related contexts when adopting both offender’s (Experiment 1 and 2) and victim’s (Experiment 3) perspectives. Interestingly, crime-related scenarios produced the lowest memory retention in Experiments 2 and 3, indicating no mnemonic benefit resulting from crimerelated processing. Furthermore, in Experiments 1 and 2, we failed to replicate the standard survival processing effect, while in Experiment 3 the superior survival memory retention emerged in comparison with the standard control conditions (i.e., moving and pleasantness). Overall, our experiments showed that crime-related contexts did not lead to superior memory retention. Moreover, although we detected some failures to replicate the survival processing effect, this evidence is not sufficiently compelling to argue that there was a general absence of the survival processing advantage