Розробка ринково-орієнтованих методів вартісної оцінки об’єктів інтелектуальної власності

Розроблено методичні положення визначення вартості інтелектуальних новацій на основі комбінованого середньовагового методу з використанням їх загальних та специфічних особливостей.Methodical positions of determination of cost of intellectual innovations are developed on the basis of the combined middling gravimetric method with the use of their general and specific features

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Organism descriptor(s) : Brassica oleracea var. botrytis Descriptor(s) : cauliflowers, crop yield, irrigation, mulching, soil depth, soil temperature, soil water, trickle irrigation Identifier(s) : heading broccoli, soil moisture, watering Geographical Location(s) : India, Maharashtra Broader term(s) : Brassica oleracea, Brassica, Brassicaceae, Brassicales, eudicots, angiosperms, Spermatophyta, plants, eukaryotes, India, Commonwealth of Nations, Developing Countries, South Asia, AsiaField experiment was conducted at Instructional Farm of Department of Irrigation and Drainage Engineering, College of Agricultural Engineering and Technology, Dr.BSKKV, Dapoii (India), during rabi season in 2014-2015. The main objective of the study was to investigate the effect of mulching and irrigation levels on soil temperature, soil moisture, and yield of drip irrigated cauliflower. The field experiment was laid out in Split Plot Design (SPD) with three irrigation levels in the main plots and four mulching levels in the sub plots. Treatments were replicated four times. Soil temperature was measured at 5 cm and 15 cm soil depth. The morning soil temperature was found maximum (20.38°C) at 15 cm depth under black plastic mulch. The afternoon soil temperature was found maximum (25°C) at 5 cm depth under black plastic mulch. Silver mulch had minimum temperature variation (0.75°C) and maintained the soil temperature within the optimum temperature range for cauliflower (15-22°C). The soil moisture content was maintained close to field capacity (26.01 per cent) throughout the growing period under a combination of 0.8 ETc and silver plastic mulch. The same treatment combination had maximum yield (29.69 t ha-1), water use efficiency (12.92 q ha-1 cm-1), net income (Rs. 5,57,159.35 ha-1) and B:C ratio (2.67). It was concluded that, in order to obtain higher marketable yield, water use efficiency and net return of cauliflower during rabi season, use of 80 percent of crop water requirement through drip irrigation with silver mulch could be the best option under agroclimatic conditions of Dapoli in Konkan region of Maharashtra, India.Not Availabl

De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is the main pathology underlying steroid-resistant nephrotic syndrome (SRNS) and a leading cause of chronic kidney disease. Monogenic forms of pediatric SRNS are predominantly caused by recessive mutations, while the contribution of de novo variants (DNVs) to this trait is poorly understood. Using exome sequencing (ES) in a proband with FSGS/SRNS, developmental delay, and epilepsy, we discovered a nonsense DNV in TRIM8, which encodes the E3 ubiquitin ligase tripartite motif containing 8. To establish whether TRIM8 variants represent a cause of FSGS, we aggregated exome/genome-sequencing data for 2,501 pediatric FSGS/SRNS-affected individuals and 48,556 control subjects, detecting eight heterozygous TRIM8 truncating variants in affected subjects but none in control subjects (p = 3.28 × 10(−11)). In all six cases with available parental DNA, we demonstrated de novo inheritance (p = 2.21 × 10(−15)). Reverse phenotyping revealed neurodevelopmental disease in all eight families. We next analyzed ES from 9,067 individuals with epilepsy, yielding three additional families with truncating TRIM8 variants. Clinical review revealed FSGS in all. All TRIM8 variants cause protein truncation clustering within the last exon between residues 390 and 487 of the 551 amino acid protein, indicating a correlation between this syndrome and loss of the TRIM8 C-terminal region. Wild-type TRIM8 overexpressed in immortalized human podocytes and neuronal cells localized to nuclear bodies, while constructs harboring patient-specific variants mislocalized diffusely to the nucleoplasm. Co-localization studies demonstrated that Gemini and Cajal bodies frequently abut a TRIM8 nuclear body. Truncating TRIM8 DNVs cause a neuro-renal syndrome via aberrant TRIM8 localization, implicating nuclear bodies in FSGS and developmental brain disease

Proceedings of National Conference on Relevance of Engineering and Science for Environment and Society

This conference proceedings contains articles on the various research ideas of the academic community and practitioners presented at the National Conference on Relevance of Engineering and Science for Environment and Society (R{ES}2 2021). R{ES}2 2021 was organized by Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India on July 25th, 2021. Conference Title: National Conference on Relevance of Engineering and Science for Environment and SocietyConference Acronym: R{ES}2 2021Conference Date: 25 July 2021Conference Location: Online (Virtual Mode)Conference Organizers: Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India