The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders

INTRODUCTION: Cognitive deficits are present in some, but not all patients with schizophrenia-spectrum disorders (SSD). We and others have demonstrated three cognitive clusters: cognitively intact patients, patients with deficits in a few domains and those with global cognitive deficits. This study aimed to identify cognitive subtypes of early-phase SSD with matched controls as a reference group, and evaluated cognitive subgroups regarding clinical and brain volumetric measures. METHODS: Eighty-six early-phase SSD patients were included. Hierarchical cluster analysis was conducted using global performance on the Brief Assessment of Cognition in Schizophrenia (BACS). Cognitive subgroups were subsequently related to clinical and brain volumetric measures (cortical, subcortical and cortical thickness) using ANCOVA. RESULTS: Three distinct cognitive clusters emerged: relative to controls we found one cluster of patients with preserved cognition (n = 25), one moderately impaired cluster (n = 38) and one severely impaired cluster (n = 23). Cognitive subgroups were characterized by differences in volume of the left postcentral gyrus, left middle caudal frontal gyrus and left insula, while differences in cortical thickness were predominantly found in fronto-parietal regions. No differences were demonstrated in subcortical brain volume. DISCUSSION: Current results replicate the existence of three distinct cognitive subgroups including one relatively large group with preserved cognitive function. Cognitive subgroups were characterized by differences in cortical regional brain volume and cortical thickness, suggesting associations with cortical, but not subcortical development and cognitive functioning such as attention, executive functions and speed of processing

Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders

Background: Excessive C4A-gene expression may result in increased microglia-mediated synaptic pruning. As C4A overexpression is observed in schizophrenia spectrum disorders (SSD), this mechanism may account for the altered brain morphology (i.e. reduced volume and cortical thickness) and cognitive symptoms that characterize SSD. Therefore, this study investigates the association of C4A serum protein levels with brain morphology and cognition, and in particular whether this association differs between recent-onset SSD (n = 69) and HC (n = 40). Methods: Serum C4A protein levels were compared between groups. Main outcomes included total gray matter volume, mean cortical thickness and cognitive performance. Regression analysis on these outcomes included C4A level, group (SSD vs. HC), and C4A*Group interactions. All statistical tests were corrected for age, sex, BMI, and antipsychotic medication dose. Follow-up analyses were performed on separate brain regions and scores on cognitive sub-tasks. Results: The group difference in C4A levels was not statistically significant (p = 0.86). The main outcomes did not show a significant interaction effect (p &gt; 0.13) or a C4A main effect (p &gt; 0.27). Follow-up analyses revealed significant interaction effects for the left medial orbitofrontal and left frontal pole volumes (p &lt; 0.001): C4A was negatively related to these volumes in SSD, but positively in HC. Conclusion: This study demonstrated that C4A was negatively related to – specifically – frontal brain volumes in SSD, but this relation was inverse for HC. The results support the hypothesis of complement-mediated brain volume reduction in SSD. The results also suggest that C4A has a differential association with brain morphology in SSD compared to HC.</p

Friedmann Robertson-Walker model in generalised metric space-time with weak anisotropy

A generalized model of space-time is given, taking into consideration the anisotropic structure of fields which are depended on the position and the direction (velocity).In this framework a generalized FRW-metric the Raychaudhouri and Friedmann equations are studied.A long range vector field of cosmological origin is considered in relation to the physical geometry of space-time in which Cartan connection has a fundamental role.The generalised Friedmann equations are produced including anisotropic terms.The variation of anisotropy $z_t$ is expressed in terms of the Cartan torsion tensor of the Finslerian space-time.A possible estimation of the anisotropic parameter $z_t$ can be achieved with the aid of the de-Sitter model of the empty flat universe with weak anisotropy. Finally a physical generalisation for the model of inflation is also studied.Comment: 21 pages- to appear in GR

Measurement of the near-threshold e+e−→DDˉe^+e^- \to D \bar D cross section using initial-state radiation

We report measurements of the exclusive cross section for $e^+e^- \to D \bar D$, where $D=D^0$ or $D^+$, in the center-of-mass energy range from the $D \bar D$ threshold to $5\mathrm{GeV}/c^2$ with initial-state radiation. The analysis is based on a data sample collected with the Belle detector with an integrated luminosity of 673 $\mathrm{fb}^{-1}$.Comment: Presented at EPS07 and LP07 conferences, published in PRD(RC

Precise measurement of hadronic tau-decays with an eta meson

We have studied hadronic tau decay modes involving an eta meson using 490 fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. The following branching fractions have been measured: B(tau- -> K- eta nu)=(1.58 +- 0.05 +- 0.09)x 10^{-4}, B(tau- -> K- pi0 eta nu)=(4.6 +- 1.1 +- 0.4)x 10^{-5}, B(tau- -> pi- pi0 eta nu)=(1.35 +- 0.03 +- 0.07)x 10^{-3}, B(tau- -> pi- KS eta nu)=(4.4 +- 0.7 +- 0.2)x 10^{-5}, and B(tau- -> K^{*-} eta nu)=(1.34 +- 0.12 +- 0.09)x 10^{-4}. These results are substantially more precise than previous measurements. The new measurements are compared with theoretical calculations based on the CVC hypothesis or the chiral perturbation theory. We also set upper limits on branching fractions for tau decays into K- KS eta nu, pi- KS pi0 eta nu, K- eta eta nu, pi- eta eta nu and non-resonant K- pi^0 eta nu final states.Comment: 24 pages, 7 figure

Moments of the Hadronic Invariant Mass Spectrum in B --> X_c l nu Decays at Belle

We present a measurement of the hadronic invariant mass squared (M^2_X) spectrum in charmed semileptonic B meson decays B --> X_c l nu based on 140 fb^-1 of Belle data collected near the Y(4S) resonance. We determine the first, the second central and the second non-central moments of this spectrum for lepton energy thresholds ranging between 0.7 and 1.9 GeV. Full correlations between these measurements are evaluated.Comment: published version of the paper (one figure added, minor changes in the text); 16 pages, 3 figures, 10 table

Search for new charmonium states in the processes e+ e- --> J/psi D(*) D(*) at sqrt{s} ~ 10.6 GeV

We present a study of the X(3940) state in the process e+e- -> J/psi D* Dbar. The X(3940) mass and width are measured to be (3942 +7 -6 +- 6)MeV/c^2 and Gamma=(37 + 26 - 15 +- 8 MeV. In the process e+e- -> J/psi D* D*bar we have observed another charmonium-like state, which we denote as X(4160), in the spectrum of invariant masses of D*+ D*- combinations. The X(4160) parameters are M= 4156 + 25 - 20 +- 15 MeV/c^2 and Gamma = 139 + 111 -61 +- 21 MeV. The analysis is based on a data sample with an integrated luminosity of 693 /fb recorded near the Upsilon(4S) resonance with the Belle detector at the KEKB e+ e- asymmetric-energy collider.Comment: 7 pages, 2 figures Contribution paper for conferences EPS2007 and Lepton Photon 2007, Belle-Conference-070

Study of charmonia in four-meson final states produced in two-photon collisions

We report measurements of charmonia produced in two-photon collisions and decaying to four-meson final states, where the meson is either a charged pion or a charged kaon. The analysis is based on a 395fb^{-1} data sample accumulated with the Belle detector at the KEKB electron-positron collider. We observe signals for the three C-even charmonia eta_c(1S), chi_{c0}(1P) and chi_{c2}(1P) in the pi^+pi^-pi^+pi^-, K^+K^-pi^+pi^- and K^+K^-K^+K^- decay modes. No clear signals for eta_c(2S) production are found in these decay modes. We have also studied resonant structures in charmonium decays to two-body intermediate meson resonances. We report the products of the two-photon decay width and the branching fractions, Gamma_{gamma gamma}B, for each of the charmonium decay modes.Comment: 22 pages, 12 figure

Observation of the ϕ(1680)\phi(1680) and the Y(2175) in e+e−→ϕπ+π−e^+ e^- \to \phi\pi^+\pi^-

The cross sections for $e^+ e^- \to \phi\pi^+\pi^-$ and e^+ e^- \to \phi \fzero are measured from threshold to $\sqrt{s}=3.0$ $\hbox{GeV}$ using initial state radiation. The analysis is based on a data sample of 673 fb$^{-1}$ collected on and below the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. First measurements are reported for the resonance parameters of the $\phi(1680)$ in the $\phi\pi^+\pi^-$ mode: $m=(1689\pm 7\pm 10)$ MeV/$c^2$ and $\Gamma=(211\pm 14\pm 19)$ MeV/$c^2$. A structure at $\sqrt{s}=2.1 \hbox{GeV}/c^2$, corresponding to the so called Y(2175), is observed; its mass and width are determined to be $2079\pm13^{+79}_{-28}$ MeV/$c^2$ and $192\pm23^{+25}_{-61} \hbox{MeV}/c^2$, respectively.Comment: 11 pages, 6 figures. Add one plot. Accepted by Phys.Rev.D(RC

Search for \bar{B}^0\to\Lambda_c^+\bar{\Lambda}_c^- decay at Belle

We search for the doubly charmed baryonic decay $\bar{B}^0\to\Lambda_c^+\bar{\Lambda}_c^-$, in a data sample of $520\times10^6$ $B{\bar B}$ events accumulated at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric e^+e^- collider. We find no significant signal and set an upper limit of ${\cal B}(\bar{B}^0\to\Lambda_c^+\bar{\Lambda}_c^-)<6.2\times10^{-5}$ at 90% confidence level. The result is significantly below a naive extrapolation from ${\cal B}(B^-\to\Xi_c^0\bar{\Lambda}_c^)$ assuming a simple Cabibbo-suppression factor of $|V_{cd}/V_{cs}|^2$. The small branching fraction could be attributed to a suppression due to the large momentum of the baryonic decay products, which has been observed in other charmed baryonic two-body B decays. trend observed in other charmed baryonic two-body B decays.Comment: 12 page, 5 figures. Contribution paper for conferences EPS2007 and Lepton Photon 2007, Belle-Conference-070