Infection of Mycobacterium mageritense at surgical site: A first case report of India

A 27 years old non diabetic, normotensive, female had undergone lower segment caesarean section (LSCS) with tubular ligation. She complained discharge at left side of stitch line after about 5 weeks of operation, and was treated with broad spectrum antibiotics. As she did not improve, first and second debridement was done in January and February 2017 and pyogenic cultures sent were sterile. Later she was advised  for Multiple detector computed tomography (MDCT) in March 2017, which revealed accumulations in pre-peritoneal space of urinary bladder posteriorly and reached to anterior wall of uterus. This pus was from multiple sinuses and were sent for mycobacterial cultures which showed growth of MOTT- M.mageritense further identified by MALDI-TOF and supported by molecular technologies. After identification of this Non-tuberculosis mycobacteria (NTM). She was treated for the same and recovered completely after seven months of anti-NTM treatment. This is the first reported case of M. mageritense in skin and soft tissue in India. Literature also reports a few cases around the globe. &nbsp

Direct synthesis of 2-(cycloalkylamino)-3,4-substituted thiophenes via selective deprotonation-cyclization of aroyl ketene N,S-acetals

Acyclic and cyclic aroyl ketene N,S-acetals undergo regioselective deprotonation-cyclization via dipole stabilized carbanion in the presence of LDA/THF to afford the corresponding 2-(cycloalkylamino)-4-aryl or 3,4-annelated thiophenes in moderate to good yields

The raising epidemic of COPD in women

Background: Chronic obstructive pulmonary disease (COPD) represents an important public health challenge that is both preventable and treatable. Although it is more frequently observed in males, the number of females with COPD is on the rise due to either active smoking or passive exposure and biomass fuel combustion.Methods: It is a cross sectional study comprising forty female patients with signs and symptoms of COPD and graded according to Global association for obstructive lung diseases (GOLD) spirometry strategy. For all the enrolled patients, clinical history was taken and investigations like chest X-ray, Spirometry, Six minute walk distance test (6MWD) and BODE index was assessed.Results: The majority of cases (72.5%) belong to fifth to sixth decade. Most of cases were from rural area. 85% of the COPD females were smokers. Among non smokers biomass fuel is major risk factor. COPD is common in patients with smoking history of more than 20 years. Duration of exposure to biomass fuel exceeded 45 years in the COPD subjects. The mean 6MWD was 311 meters suggesting low exercise capacity. Most of the patients with severe COPD have BODE score >7 with poor prognosis.Conclusions: This study recognizes the prevalence of reverse chutta smoking among the COPD females and the risk of biomass exposure in the development of COPD in women, especially from rural areas. Identification and control of the risk factors are important steps in prevention and treatment of COPD.

A Self-learning Nonlinear Variable Gain Proportional Derivative (PD) Controller in Robot Manipulators

This paper proposes a nonlinear variable gain Proportional-Derivative (PD) controller that exhibits self-constructing and self-learning capabilities. In this method, the conventional linear PD controller is augmented with a nonlinear variable PD gain control signal using a dynamic structural network. The dynamic structural network known as Growing Multi-Experts etwork grows in time by placing hidden nodes in regions of the state space visited by the system during operation. This results in a network that is "economic" in terms of network sileo The proposed approach enhances the adaptability of conventional PD controller while preserving its' linear structure. Based on the simulation study on variable load and friction compensation, the fast adaptation is shown to be able to compensate the non-linearity and the uncertainty in the robotic system

Synthesis and anti–microbial activity of 1,2,3–triazole tethered nitroguiacol ethers

Nitro aromatic/nitrophenols have been widely distributed in nature and are mostly isolated from marine microorganisms and had shown a broad spectrum of anti–microbial activities against a wide range of microbial pathogens. The objective of the present work is to Synthesize some new 1,2,3–triazole tethered nitroguiacol ethers and evaluated of their anti–bacterial and anti–fungal activities. A focused library of 1,2,3-triazole tethered nitroguiacol ethers were prepared by employing Cu (I) catalyzed click chemistry reaction and evaluated for their antimicrobial activities by broth microdilution method. Among the tested compounds, compounds 8e, 8f, 8g, and 8i exhibited broad–spectrum activity against selected pathogenic strains, with the MIC of 8 µg/mL for gram–positive bacteria (Staphylococcus aureus), 16 µg/mL for Pseudomonas aeruginosa (gram–negative bacteria), and Candida species, respectively. Future investigations with this class of compounds may lead to the development of potential candidates for antimicrobial drug discovery.Â

ESTIMATION OF PRIMIDONE IN COMMERCIAL DOSAGE FORMS USING A SIMPLE AND CONVENIENT HPLC METHOD

ABSTRACT A simple fast and precise reverse phase high performance liquid chromatographic method has been developed for the determination of Primidone Tablets. A symmetry (5µ, 150 x 4 .6mm column) in isocratic mode with methanol: Water (50:50) as mobile phase. The Flow rate is1.0ml/min and effluent is monitored at 210nm

Potential of Big Data Analytics in Bio-medical and Health Care Arena: An Exploratory Study

With the leveraging emerging big Data in every industry Big Data can amalgamate all data related to patient to get a complete view of patient to analyze and predict the outcomes Using big data analytics as tools It can enhance development in new drugs health care financing process and clinical approaches and extends a lots of benefits such as better health care quality and efficiency fraud detection and early disease detection by means of analytics of big data This paper provides a general survey of current progress and advances in research arena of big data bio-medical and health care and some major challenges of big data concept and characteristics this concerns includes big data from bio-medical and health care arena benefits of big data its applications and opportunities Methods and technology progress about big data in bio-medical and health care and challenges of big data in both bio-medical and healthcare are also discusse

CHARACTERIZATION AND DEFLUORIDATION STUDIES OF ACTIVATED DOLICHOS LAB LAB CARBON

ABSTRACT The adsorption studies on the removal of fluoride from potable water using activated Dolichos Lablab Carbon (NDLC) was carried out under various experimental conditions. The maximum adsorption was observed to be a function of the solution contact time, initial concentration of fluoride and adsorbent dose. The effect of various process parameters have been investigated by following the batch adsorption technique at 30 ± 1˚C. The adsorbent capacity of adsorbent for fluoride was obtained by using linear Langmuir and Freundlich isotherms

Genotoxicity in lead treated human lymphocytes evaluated by micronucleus and comet assays

502-508Lead (Pb) which plays a significant role in modern industry is related to a broad range of physiological, biochemical, behavioural and genetical dysfunctions. Its exposure leads to an increased frequency of genetic aberrations in humans. Hence, this study was designed to assess the genotoxic effect of lead acetate at three dosage levels (10, 25 and 50 µg/mL) by employing: the Cytokinesis Block Micronucleus (CBMN) assay and the Comet assay in Peripheral Blood Lymphocyte Cultures. The results of this study revealed an increased level of DNA damage among treated groups. A significant increase in the tail length of comets and other indices was observed at 25 and 50 µg/mL concentrations comparatively. Thus, lead acetate induced single-strand breaks (SSB) and double strand breaks (DSB) in DNA, alkali-labile sites (ALS), oxidative DNA damage as well as DNA-DNA/DNA-protein/DNA-metal cross linking as evidenced by the Comet assay. The chromosome breakage, DNA misrepair, chromosome loss and telomere end fusion were determined by the Micronucleus assay. Micronucleus frequency in treated lymphocytes was significantly higher as compared to controls. Nucleoplasmic bridges increased significantly and Nuclear buds increased at higher two doses only in exposed cultures. Thus, these assays are better indices for lead induced genotoxicity and metal-nucleus interactions

A Hybrid Intelligent Active Force Controller for Articulated Robot Arms Using Dynamic Structure Neural Network

The key feature of this paper is the application of a robotic control concept - Active Force Control (AFC). In this type of control, the unknown friction effect of the robotic arm may be compensated by the AFC method. AFC involves the direct measurement of the acceleration and force quantities and therefore, the process of estimating the system 'disturbance' due to friction becomes instantaneous and purely algebraic. However, the AFC strategy is very practical provided a good estimation of the inertia matrix of articulated robot arm is acquired. A dynamic structure neural network - Growing Multi-experts Network (GMN) is developed to estimate the robot inertia matrix. The growing and pruning mechanism of GMN ensures the optimum size of the network that results in an excellent generalization capability of the network. Active Force Control ( AFC) in conjunction with GMN successfully reduces the velocity and position tracking errors in spite of robot joint friction. The embedded GMN is capable of coupling the inertia matrix estimation online that clearly enhances the performance of AFC controller. The robustness and effectiveness of the new hybrid neural network-based AFC scheme are demonstrated clearly with regard to two link articulated robot and a simulated two-degree of freedom Puma 560 robot