16 research outputs found
What Causes Desmoplastic Reaction in Small Intestinal Neuroendocrine Neoplasms?
PURPOSE OF REVIEW: Mesenteric desmoplasia in small intestinal neuroendocrine neoplasms (SINENs) is associated with increased morbidity and mortality. In this paper, we discuss the development of desmoplasia in SINENs. RECENT FINDINGS: The fibrotic reactions associated with these tumours could be limited to the loco-regional environment of the tumour and/or at distant sites. Mesenteric fibrotic mass forms around a local lymph node. Formation of desmoplasia is mediated by interactions between the neoplastic cells and its microenvironment via number of profibrotic mediators and signalling pathways. Profibrotic molecules that are mainly involved in the desmoplastic reaction include serotonin, TGFβ (transforming growth factor β) and CTGF (connective tissue growth factor), although there is some evidence to suggest that there are a number of other molecules involved in this process. Desmoplasia is a result of autocrine and paracrine effects of multiple molecules and signalling pathways. However, more research is needed to understand these mechanisms and to develop targeted therapy to minimise desmoplasia
High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Improved Prognostic Stratification With the New World Health Organization 2019 Classification A Validation Study From a Single-Institution Retrospective Analysis
Objectives: There is a pressing need to develop clinical management pathways for grade 3 (G3) gastroenteropancreatic neuroendocrine neoplasms (GEP NEN).
Methods: We performed a retrospective study on patients with metastatic G3 GEP NEN. The relationship between baseline characteristics and progression-free survival and overall survival was analyzed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards model.
Results: We included 142 patients (74 well-differentiated neuroendocrine tumors [WDNETs], 68 poorly differentiated neuroendocrine carcinomas [PDNECs]). Patients with WDNET had prolonged survival compared with PDNEC (median, 24 vs 15 months, P = 0.0001), which persisted in both pancreatic and nonpancreatic cohorts. Well-differentiated morphology, Ki-67 <50% and positive somatostatin receptor imaging were independently associated with prolonged survival. Of the subgroup treated with first-line platinum-based chemotherapy, response rates were favorable (partial response, 47%; stable disease, 30%); there was no significant difference in response rates nor progression-free survival between WDNET and PDNEC despite significantly prolonged overall survival in the WDNET cohort.
Conclusions: Our study corroborates the knowledge of 2 prognostically distinct subgroups within the World Health Organization 2019 G3 GEP NEN population, observed in both pancreatic and nonpancreatic gastrointestinal cohorts. Definitive management pathways are needed to reflect the differences between G3 WDNET and PDNEC
Is local excision sufficient in selected grade 1 or 2 type III gastric neuroendocrine neoplasms?
Purpose Type III gastric neuroendocrine neoplasms (g-NENs) have
historically been regarded as aggressive tumours, hence current
guidelines advocate radical surgery with lymph node dissection. Data on
the roles of endoscopic or less extensive surgical resections are more
limited. The aim of our study is to evaluate the clinicopathological
features and long-term outcomes of patients undergoing endoscopic or
limited surgical resection for localised grade 1 or 2 type III g-NENs
when compared to radical surgery. Methods Retrospective analysis of all
patients diagnosed with a localised grade 1 or 2 type III g-NENs across
six tertiary NEN centers between 2006 and 2019. Results Forty-five
patients were diagnosed with a potentially resectable grade 1 or 2 type
III g-NEN of whom 36 underwent either endoscopic or surgical resection.
No statistically significant differences were found between the three
resection groups in terms of patient age, tumour location, grade or
size. Only tumour size was found to be significantly associated with
poor clinical outcome (p = 0.012) and ROC curve analysis identified
tumour size >10 mm as a negative predictor (AUC:0.8030, p = 0.0021).
Tumours >10 mm were also more likely to be associated with lymph node
metastases on imaging and histology (p = 0.039 and p = 0.026
respectively). Conclusions Localised grade 1 or 2 type III g-NENs had a
good prognosis in this series. Tumour size >10 mm was the most
significant prognostic factor affecting patient outcome. Endoscopic
resection or limited surgical resection is feasible and safe in small
type III g-NENs which demonstrate favourable grade 1/2, well
differentiated histology
Development of a Quality of Life Questionnaire for Patients with Pancreatic Neuroendocrine Tumours (the PANNET module)
Pancreatic Neuroendocrine Tumours (panNET) are heterogeneous neoplasms characterised usually by slow growth and secretion of hormones, which often cause symptoms. The effect of these symptoms on Quality of Life (QoL) has not been examined previously in detail. Methods EORTC (European Organisation for Research and Treatment of Cancer) guidelines were followed in phases 1-3 to produce a potential module of questions usable for trials in panNET, focusing on three common types of panNET. For two less common types, a list of symptoms was constructed. Following an extensive literature search and Phase 1a interviews with patients and Healthcare workers, a long list of potential issues (169) was obtained. This list was shown to 12 patients from 3 countries in Phase 1b interviews to check that no items were missed. The list was reduced to 57 issues. The list of issues was converted to questions, mainly from existing validated questions within the EORTC item library. The list of questions was then used in a phase 3 international study in 8 countries using7 languages. Result A provisional module of 24 items is presented for use in non-functioning panNET, Gastrinoma and Insulinoma. Conclusion This module increases knowledge concerning QoL in this condition and may be a useful adjunct in clinical trials. A Phase 4 trial is being considered for validation of this Questionnaire