119 research outputs found
Demographic, clinical and pathological characterisation of patients with colorectal and anal cancer followed between 2013 and 2016 at Maputo Central Hospital, Mozambique
Publisher Copyright: © 2021 ecancer Global Foundation. All rights reserved.Purpose: The aim of this study was to investigate colorectal cancer (CRC) data and anal cancer data from Maputo Central Hospital (MCH), the largest hospital and a reference for oncological diseases in Mozambique, with the aim of characterising the disease profile in view to define an appropriate control programme. Methods: MCH records from the Pathology and Surgery Services and MCH Cancer Registry database were assessed to obtain retrospective clinical and pathologic data of patients with CRC or anal cancer admitted to and treated between 13 December 2013 and 23 March 2016. Results: The female gender was more prevalent (54.8%), even when anal cancers were excluded. Median age was 54 years (20 99). Most patients (51.6%) lived in the city of Maputo. The most common presenting symptom was found to be rectal bleeding. Adenocarcinoma was the most frequent histological type, and the most prevalent anatomical site was the rectum. Most of the cases were diagnosed at MCH in advanced stages. Colostomy was the most frequent surgical procedure and performed in 38.7% of the patients. Most cases of anal cancer occurred in human immunodeficiency virus-infected patients. Most patients had a poor prognosis due to advanced stage at first diagnosis. Conclusion: We observed an increase in cases of CRC and anal cancer in Mozambique and mostly diagnosed at advanced stages, which anticipates a dismal prognosis. Our data supports the urgent need of a comprehensive public health programme dedicated to solving this growing concern.publishersversionpublishe
Weak surveillance and policy attention to cancer in global health: the example of Mozambique
Cancer is an emerging public health problem in sub-Saharan
Africa due to population growth, ageing and westernisation of
lifestyles. The increasing burden of cancer calls for urgent
policy attention to develop cancer prevention and control
programmes. Cancer surveillance is an essential prerequisite.
Only one in five low-income and middle-income countries have the
necessary data to drive policy and reduce the cancer burden. In
this piece, we use data from Mozambique over a 50-year period to
illustrate cancer epidemiological trends in low-income and
middle-income countries to hypothesise potential circumstances
and factors that could explain changes in cancer burden and to
discuss surveillance weaknesses and potential improvements. Like
many low-income and middle-income countries, Mozambique faces
the dual challenge of a still high morbidity and mortality due
to infectious diseases in rural areas and increased incidence of
cancers associated with westernisation of lifestyles in urban
areas, as well as a rise of cancers related to the HIV epidemic.
An increase in cancer burden and changes in the cancer profile
should be expected in coming years. The Mozambican healthcare
and health-information systems, like in many other low-income
and middle-income countries, are not prepared to face this
epidemiological transition, which deserves increasing policy
attention
Trends in Cancer Incidence in Maputo, Mozambique, 1991-2008
BACKGROUND: Very limited information is available regarding the
incidence of cancer in sub-Saharan Africa. We analyzed changes
in cancer patterns from 1991 to 2008 in Maputo (Mozambique).
METHODS: We calculated the rates of incidence of different
cancer sites by sex in the 5-year age-group of the population of
Maputo city as well as age-standardized rates (ASRs) and average
annual percentage changes (AAPC). RESULTS: Over the 18-year
study period a total of 12,674 cases of cancer (56.9% females)
were registered with an overall increase in the risk of cancer
in both sexes. In males, the most common cancers were those of
the prostate, Kaposi sarcoma (KS) and the liver. Prostate cancer
showed the most dramatic increase over the whole study period
(AAPC +11.3%; 95% CI: 9.7-13.0), with an ASR of 61.7 per 105 in
2003-2008. In females, the most frequent cancers were of the
uterine cervix, the breast and KS, with the former increasing
along the whole study period (AAPC + 4.7%; 95% CI: 3.4-6) with
an ASR of 62.0 per 105 in 2003-2008 as well as breast cancer
(AAPC +6.5%; 95%CI: 4.3-8.7). CONCLUSIONS: Overall, the risk of
cancer rose in both sexes during the study period, particularly
among cancers associated with westernization of lifestyles
(prostate, breast), combined with increasingly rising incidences
or limited changes in cancers associated with infection and
poverty (uterine cervix, liver). Moreover, the burden of
AIDS-associated cancers has shown a marked increase
An Autopsy Study of Maternal Mortality in Mozambique: The Contribution of Infectious Diseases
Clara Menendez and colleagues analyze 139 complete autopsies following maternal deaths in Maputo, Mozambique and find a predominance of infectious and preventable causes
An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
Background Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods is lacking, but is essential to guide policy-makers and health professionals to reduce this intolerable burden. The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios. Methods and Findings We conducted a prospective study between October 2002 and December 2004 on the causes of maternal death in a tertiary-level referral hospital in Maputo, Mozambique, using complete autopsies with histological examination. HIV detection was done by virologic and serologic tests, and malaria was diagnosed by histological and parasitological examination. During 26 mo there were 179 maternal deaths, of which 139 (77.6%) had a complete autopsy and formed the basis of this analysis. Of those with test results, 65 women (52.8%) were HIV-positive. Obstetric complications accounted for 38.2% of deaths; haemorrhage was the most frequent cause (16.6%). Nonobstetric conditions accounted for 56.1% of deaths; HIV/AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis were the most common causes (12.9%, 12.2%, 10.1% and 7.2% respectively). Mycobacterial infection was found in 12 (8.6%) maternal deaths. Conclusions In this tertiary hospital in Mozambique, infectious diseases accounted for at least half of all maternal deaths, even though effective treatment is available for the four leading causes, HIV/AIDS, pyogenic bronchopneumonia, severe malaria, and pyogenic meningitis. These observations highlight the need to implement effective and available prevention tools, such as intermittent preventive treatment and insecticide-treated bed-nets for malaria, antiretroviral drugs for HIV/AIDS, or vaccines and effective antibiotics for pneumococcal and meningococcal diseases. Deaths due to obstetric causes represent a failure of health-care systems and require urgent improvement
Congenital cytomegalovirus, parvovirus and enterovirus infection in Mozambican newborns at birth: A cross-sectional survey
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is the
most prevalent congenital infection acquired worldwide, with
higher incidence in developing countries and among HIV-exposed
children. Less is known regarding vertical transmission of
parvovirus B19 (B19V) and enterovirus (EV). We aimed to assess
the prevalence of CMV, B19V and EV vertical transmission and
compare results of screening of congenital CMV obtained from two
different specimens in a semirural Mozambican maternity.
METHODS: A cross sectional study was conducted among pregnant
mothers attending Manhica District Hospital upon delivery.
Information on maternal risk factors was ascertained. Dried
umbilical cord (DUC) samples were collected in filter paper for
CMV, B19V and EV detection by real-time polymerase chain
reaction (RT-PCR), and nasopharyngeal aspirates (NPA) to test
for CMV by RT-PCR. Maternal blood samples and placental biopsy
samples were also obtained to investigate CMV maternal serology,
HIV status and immunopathology. RESULTS: From September 2014 to
January 2015, 118 mothers/newborn pairs were recruited.
Prevalence of maternal HIV infection was 31.4% (37/118). CMV
RT-PCR was positive in 3/115 (2.6%) of DUC samples and in 3/96
(6.3%) of NPA samples obtained from neonates. The concordance of
the RT-PCR assay through DUC with their correspondent NPA sample
was moderate (Kappa = 0.42 and p<0.001. No differences on
cCMV prevalence were found among HIV-exposed and unexposed. All
(100%) mothers were seropositive for CMV IgG. RT-PCR of EV and
B19V in DUC were both negative in all screened cases. No
histological specific findings were found in placental tissues.
No risk factors associated to vertical transmission of these
viral infections were found. CONCLUSIONS: This study indicates
the significant occurrence of vertical transmission of CMV in
southern Mozambique. Larger studies are needed to evaluate the
true burden, clinical relevance and consequences of congenital
infections with such pathogens in resource-constrained settings
Development of a post-mortem procedure to reduce the uncertainty regarding causes of death in developing countries
A major failure of our global society in the 21st century is that many people in developing countries are not only born and live without any official record of their existence a flagrant deprivation of an essential human right but also die without having been seen by medically qualified personnel. The resultant uncertainty about the real burden of specific causes of death is being increasingly recognised by international health and funding agencies as a crucial limitation in the prioritisation of effective public health programmes and assessment of their effect
Pathological Methods Applied to the Investigation of Causes of Death in Developing Countries: Minimally Invasive Autopsy Approach
BACKGROUND AND AIMS: Complete diagnostic autopsies (CDA) remain the gold standard in the determination of cause of death (CoD). However, performing CDAs in developing countries is challenging due to limited facilities and human resources, and poor acceptability. We aimed to develop and test a simplified minimally invasive autopsy (MIA) procedure involving organ-directed sampling with microbiology and pathology analyses implementable by trained technicians in low- income settings. METHODS: A standardized scheme for the MIA has been developed and tested in a series of 30 autopsies performed at the Maputo Central Hospital, Mozambique. The procedure involves the collection of 20 mL of blood and cerebrospinal fluid (CSF) and puncture of liver, lungs, heart, spleen, kidneys, bone marrow and brain in all cases plus uterus in women of childbearing age, using biopsy needles. RESULTS: The sampling success ranged from 67% for the kidney to 100% for blood, CSF, lung, liver and brain. The amount of tissue obtained in the procedure varied from less than 10 mm2 for the lung, spleen and kidney, to over 35 mm2 for the liver and brain. A CoD was identified in the histological and/or the microbiological analysis in 83% of the MIAs. CONCLUSIONS: A simplified MIA technique allows obtaining adequate material from body fluids and major organs leading to accurate diagnoses. This procedure could improve the determination of CoD in developing countrie
Carriage prevalence of Salmonella enterica serotype Typhi in gallbladders of adult autopsy cases from Mozambique
INTRODUCTION: Typhoid fever is an important public health
problem in many low-income countries where asymptomatic carriers
play an important role in its dissemination. The bacterium
causing typhoid fever can live in the gallstones of asymptomatic
persons after the infection. These carriers are reservoirs of S.
Typhi, are highly contagious, and spread the disease through the
secretion of bacteria in feces and urine. The aim of this study
was to determine the carrier rate in an area of Mozambique.
METHODOLOGY: The presence of S. Typhi was analyzed in
gallbladder samples obtained from 99 adult corpses (in-hospital
deaths) from Mozambique by gold-standard culture and polymerase
chain reaction (PCR). RESULTS: Only one sample was positive with
the culture. However, nine additional samples were positive by
PCR and confirmed by DNA sequencing. Thus, the prevalence of S.
Typhi was 10.1% (10/99). CONCLUSIONS: We report a high
prevalence of S. Typhi in gallbladders among adult autopsy cases
from Mozambique
The Medical Education Partnership Initiative Effect on Increasing Health Professions Education and Research Capacity in Mozambique
Background: Mozambique is an emerging lower income country (LIC) on the southeast coast of Africa. There are significant workforce shortages in medical and health professions in the country. Mozambique was one of 12 countries in Africa that was awarded a grant through the Medical Education Partnership Initiative (MEPI) in 2010. The overarching goal of MEPI Mozambique was to enhance the capacity of medical schools to train the medical and scientific leadership corps that the country required to facilitate the training of doctors and other health professionals, and thus to strengthen the national health system. Objective: The aim of this article is to provide an overview of MEPI Mozambique activities, its outcomes and successes, lessons learned, and how these have sustainably strengthened the health sector in the country. What Was Done: The Eduardo Mondlane University (UEM) formed a partnership with the University of California, San Diego (UCSD) to implement MEPI Mozambique. A range of activities in medical education, research capacity development, electronic connectivity and information technology, and developing relationships among medical education stakeholders, were performed. Outcomes and Effects: The activities and innovations introduced under MEPI became part of the daily routine in medical education in Mozambique, dramatically influencing attitudes and perceptions. Joint research with partners leveraged research capabilities. The creation of a research support center offered a mechanism to sustainably build on MEPI achievements. Scientific knowledge generated through research has been translated into practice and policy, and has improved the working environment for health professionals. The use of interactive communication technologies enabled the scaling up of training and research in sustainable ways, and created communities of practice. Conclusion: MEPI Mozambique developed transformational long-term partnerships between UEM, UCSD and other partners. These are changing the trajectory of medical and health professions education in Mozambique and creating sustainable capacity for research
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