Clinical and Pathogenetic TLR Description

Last decade heightened interest to innate immunity in different areas of medicine is observed. In article the known data for today about a role of factors of innate immunity (toll-receptors) in pathological process is reflected, the basic cascade of the reactions started by means of TLR is displayed, the role pattern-recognition receptors is underlined at inflammatory bowel diseases

Новый стиль культуронаследования

The paper analyzes the characteristics of the broadcast of sociocultural experience. It is shown that modern historical stage is associated with the formation of a united democratic style of relationship to the cultural heritage of the past. It is caused by deep-seated patterns of culture itself, increased integration in all spheres of society. In this regard, feature of temporal being culture - the presence of social memory is highlighted. Formation of human values is the result of a kind of cultural history. As a key mechanism of successive development of a culture increasingly recognized the need for careful and responsible attitude to national cultures, to the cultural wealth of mankind.В статье анализируются особенности трансляции социокультурного опыта. Показано, что современный исторический этап связан с формированием единого демократического стиля отношения к культурному наследию прошлого. Он обусловлен глубинными закономерностями развития самой культуры, усилением интеграции во всех сферах жизни общества. В этом плане высвечивается особенность временного бытия культуры - наличие социальной памяти. Формирование общечеловеческих ценностей - это своеобразный итог истории культуры. В качестве ключевого механизма преемственного развития культуры все более осознается необходимость бережного, ответственного отношения к национальным культурам, к культурным богатствам человечества

DYNAMICALLY DETERMINE TOLL-RECEPTORS PATIENTS WITH ULCERATIVE COLITIS

Purpose: Dynamic determination of TLR 2,4,6 in patients with relapsed UC with an assessment of the use of indicators characterizing the state of TLR, as markers of remission.Materials and Methods: The study included 86 patients with recurrent UC, 39 of which have reached clinical and endoscopic remission. TLR expression on peripheral blood monocytes was determined in immunofluorescence test using monoclonal antibodies to TLR2 (СD14+CD282+), TLR4 (СD14+CD284+) и TLR6 (СD14+CD286+), conjugated with FITC (fluorescein isothiocyanate) and PE (phycoerythrin) - labeled (HyCultbiotechnology, Holland).Results: number of monocytes expressing TLR 2,4,6 increased activation of the inflammatory process, with remission rates expression of TLR 2,4,6 not different from those in the control group.Conclusion: you can use the number of monocytes expressing TLR 2,4,6 as a marker of remission

The change in the intensity of products of lipid peroxidation have simultaneously enucleation and epiphysectomical animals

As noted in previous studies, the intensity of lipid peroxidation (LP) is dependent on the functional state of organs and tissues, the impact of such factors as the postnatal development of the body, adaptation to extreme factors — ionizing radiation, breach of the oxygen supply, poisoning, change of endocrine status of the organism, stress greatly increase the LP. Increased lipid peroxidation causes structural and functional modifications in the cell membranes, compounding pathological processes. We studied the violation of intensity of lipid peroxidation in different brain structures have epiphysectomical animals after the enucleation of the optical organ. Found that epiphysectomical animal’s lipid peroxidation is enhanced. Simultaneous epiphysectomy and enucleation weakens lipid peroxidation

Physical properties of thermoelectric zinc antimonide using first-principles calculations

We report first principles calculations of the structural, electronic, elastic and vibrational properties of the semiconducting orthorhombic ZnSb compound. We study also the intrinsic point defects in order to eventually improve the thermoelectric properties of this already very promising thermoelectric material. Concerning the electronic properties, in addition to the band structure, we show that the Zn (Sb) crystallographically equivalent atoms are not exactly equivalent from the electronic point of view. Lattice dynamics, elastic and thermodynamic properties are found to be in good agreement with experiments and they confirm the non equivalency of the zinc and antimony atoms from the vibrational point of view. The calculated elastic properties show a relatively weak anisotropy and the hardest direction is the y direction. We observe the presence of low energy modes involving both Zn and Sb atoms at about 5-6 meV, similarly to what has been found in Zn4Sb3 and we suggest that the interactions of these modes with acoustic phonons could explain the relatively low thermal conductivity of ZnSb. Zinc vacancies are the most stable defects and this explains the intrinsic p-type conductivity of ZnSb.Comment: 33 pages, 8 figure

Potential of logopedic support aimed at formation of phonic breathing skills of preschoolers with hearing loss

Статья посвящена вопросам совершенствования логопедической работы по коррекции навыков речевого дыхания дошкольников с нарушением слуха.The article deals with the issues of improvement of logopedic work on rehabilitation of phonic breathing skills of preschoolers with hearing loss

Carbon Sequestration Dynamics in Urban-Adjacent Forests: A 50-Year Analysis

Achieving carbon neutrality is crucial for urban ecosystems. Forests growing near cities largely determine the state of the environment in urban areas. The aim of the present research is to assess the carbon productivity dynamics in forests near Krasnoyarsk (a large industrial center) over a 50-year period in terms of carbon sequestration and conservation. The study was based on forest inventory conducted in Karaul'noe Forestry in 1972, 1982, and 2002 and forest inventory covering six forest compartments in 2022. The forest covers 3980 ha and consists of 52 forest compartments. The analysis was based on the assessment of carbon productivity dynamics and followed four levels of principles: forestry, structure, forest compartment, and forest stand. The research was based on forest fund dynamics, analyzing methods, long-term forest inventory, assessing carbon stock, and growing stock dynamics. Pine is the dominant forest-forming species that absorbs the most carbon in the study area. Pine is long-lived, covers a vast area, and has the highest carbon sequestration potential. At the forest structure level, the predominant carbon pools are mid-late successional and late successional stands dominated by pine, birch, and aspen. Forest compartment-level analysis revealed three trends in carbon sequestration: carbon balance, a decrease in carbon sequestration, and an increase in carbon sequestration. Notably, the prevailing trend is determined by changes in carbon sequestration by dominant forest-forming species (pine). Forest stand-level analysis showed that stands have become more and more uneven-aged. About 65% of total carbon stock is concentrated in mid successional, mid-late successional and late-successional stands, and 35% in young stands. The carbon sequestration rate decreases in forests with age. However, pine forests increase biological productivity and continue to successfully sequester carbon. Deciduous forests have lost their carbon sequestration potential, and the area they occupy is currently decreasing in the study area. The development of the young generation in pine stands suggests that the carbon sequestration potential in forests growing near the city will not decrease and may even increase due to climate change. Doi: 10.28991/CEJ-2023-09-09-08 Full Text: PD

Визначення сутності попередження виникнення конфліктів у системі місцевого самоврядування

Ніколенко Л. М., Мамедова А. І. Визначення сутності попередження виникнення конфліктів у системі місцевого самоврядування / Л. М. Ніколенко, А. І. Мамедова // Актуальні проблеми держави і права : зб. наук. пр. / редкол.: В. В. Завальнюк (голов. ред.) [та ін.] ; відп. за вип. М. В. Афанасьєва. – Одеса : Юрид. л-ра, 2015. – Вип. 75. – C. 99-107.У статті здійснено дослідження сутності попередження виникнення конфліктів у системі місцевого самоврядування. Визначено рівні попередження конфліктів в органах місцевого самоврядування та їх зміст; обґрунтовано поняття попередження правового конфлікту в органах місцевого самоврядування. Доведено об’єкт, предмет і суб’єкті попередження виникнення конфліктів у системі місцевого самоврядування.Проблемы реализации конституционного права на предпринимательскую деятельность. В статье проведено исследование сущности предупреждения возникновения конфликтов в системе местного самоуправления. Определены уровни предупреждения конфликтов в органах местного самоуправления и их содержание; обосновано понятие предупреждения правового конфликта в органах местного самоуправления. Обоснованы объект, предмет и субъект предупреждения возникновения конфликтов в системе местного самоуправления.Problems of realization of constitutional right of a human and citizen on entrepreneurial activity. The article studies the nature of conflict prevention in the system of local government. The levels of conflict prevention in local government and their contents; substantiates the notion of legal conflict prevention in local government. Proved object, object and subject of conflict prevention in the system of local government