Music Like Water: Exploring the Functions of Music Through Thematic Bibliometric Analysis and Comparative ESM Study

Music has always been a functional, utilitarian resource, allowing for bonding, interaction, identity creation, and myriad additional functions for individuals and wider society. Since Alan Merriam’s pioneering work suggesting a delineation between concepts of music use and function, researchers have continued to identify a range of functions of music. Yet, two issues pervade the field; firstly, the issue of a universally accepted definition of function, and secondly, the lack of consensus between researchers as to what the functions of music are. This research aims to identify the functions of music in everyday life, grounded in the underlying contention that music is a resource employed by listeners to achieve context-dependent goals: a process referred to as music-facilitated goal attainment. This thesis addresses these issues with a preliminary theoretical investigation, followed by a mixed- methods experimental phase, and then a final grouping phase. Firstly, employing a qualitative approach to construct a pseudo-consensus, a bibliometric study was conducted and identified 52 publications containing 807 references to functions of music. The contents of the publications were examined and categorised using thematic analysis. When sorted and compiled, 45 distinct functions of music were identified. The outcome is described and visualised, forming a ‘Aggregate Thematic Functions Framework’ (ATFF). The second research phase utilised an experience sampling methodology study to confirm the validity and parity of the ATFF with the experience of real-world listeners. Participants reported music selection criteria, situational goals, activities, and locations. The resulting data were analysed using the same methodology as the previous analysis phase. 44 distinct functions of music were identified. These were then combined with the ATFF functions, resulting in a ‘Consensus Functions Framework’ (CFF). When compiled, 53 distinct functions of music are included in the CFF. The thesis also provides an extensive exploration of the contextual variables informing goal-orientated listening and a potential methodology for further investigation of the phenomenon

Records as records : excavating the DJ’s sonic archive

This paper uses four vinyl record collections to identify and infer the praxis of DJs and the evidential value of their sonic archives. The work positions the DJs’ vinyl records as a document of dance music culture while defining the DJ as the arbiter and transmitter of that record. The work adopts an archaeological perspective, questioning how to understand a DJ’s praxis from the material culture of their vinyl records, viewing these records as artefacts which together form an assemblage warranting ‘excavation,’ analysis and curation. A framework of evidence is proposed and applied to the four vinyl collections, focusing on what can be learnt from such close archaeological scrutiny. The work concludes with a discussion of themes suggested by the analysis and proposes a proactive approach to planning for the preservation of DJ archives

Harmonic analysis of 2d CFT partition functions

We apply the theory of harmonic analysis on the fundamental domain of $SL(2,\mathbb{Z})$ to partition functions of two-dimensional conformal field theories. We decompose the partition function of $c$ free bosons on a Narain lattice into eigenfunctions of the Laplacian of worldsheet moduli space $\mathbb H/SL(2,\mathbb Z)$, and of target space moduli space $O(c,c;\mathbb Z)\backslash O(c,c;\mathbb R)/O(c)\times O(c)$. This decomposition manifests certain properties of Narain theories and ensemble averages thereof. We extend the application of spectral theory to partition functions of general two-dimensional conformal field theories, and explore its meaning in connection to AdS$_3$ gravity. An implication of harmonic analysis is that the local operator spectrum is fully determined by a certain subset of degeneracies.Comment: 35+24 pages, v2: corrected a mistake in Sec 3, v3: minor errors fixe

Beauty is Attractive: Moduli Trapping at Enhanced Symmetry Points

We study quantum effects on moduli dynamics arising from the production of particles which are light at special points in moduli space. The resulting forces trap the moduli at these points, which often exhibit enhanced symmetry. Moduli trapping occurs in time-dependent quantum field theory, as well as in systems of moving D-branes, where it leads the branes to combine into stacks. Trapping also occurs in an expanding universe, though the range over which the moduli can roll is limited by Hubble friction. We observe that a scalar field trapped on a steep potential can induce a stage of acceleration of the universe, which we call trapped inflation. Moduli trapping ameliorates the cosmological moduli problem and may affect vacuum selection. In particular, rolling moduli are most powerfully attracted to the points with the largest number of light particles, which are often the points of greatest symmetry. Given suitable assumptions about the dynamics of the very early universe, this effect might help to explain why among the plethora of possible vacuum states of string theory, we appear to live in one with a large number of light particles and (spontaneously broken) symmetries. In other words, some of the surprising properties of our world might arise not through pure chance or miraculous cancellations, but through a natural selection mechanism during dynamical evolution.Comment: 50 pages, 4 figures; v2: added references and an appendix describing a related classical proces

Towards Inflation in String Theory

We investigate the embedding of brane inflation into stable compactifications of string theory. At first sight a warped compactification geometry seems to produce a naturally flat inflaton potential, evading one well-known difficulty of brane-antibrane scenarios. Careful consideration of the closed string moduli reveals a further obstacle: superpotential stabilization of the compactification volume typically modifies the inflaton potential and renders it too steep for inflation. We discuss the non-generic conditions under which this problem does not arise. We conclude that brane inflation models can only work if restrictive assumptions about the method of volume stabilization, the warping of the internal space, and the source of inflationary energy are satisfied. We argue that this may not be a real problem, given the large range of available fluxes and background geometries in string theory.Comment: 41 pages, harvmac; v2: results of appendix A extended to include branes at angles, typos corrected, refs adde

Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia.

Sentinel hospital surveillance was instituted in Australia to detect the presence of pandemic group A Streptococcus strains causing scarlet fever. Genomic and phylogenetic analyses indicated the presence of an Australian GAS emm12 scarlet fever isolate related to United Kingdom outbreak strains. National surveillance to monitor this pandemic is recommended

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570