Now with Trustworthy Research!: Comparing the Effectiveness of Propaganda Techniques Used in Advertising

Seven major propaganda deices used in advertising were examined and rated on scale of most to least successful. The techniques analyzed include the transfer, glittering generalities, bandwagon, plain folks, testimonial, card-stacking, and name-calling devices. Seven printed advertisements employing the use of each propaganda technique to sell an identical product categorized as an impulse buy were created, compared, and contrasted to develop a list rating each propaganda device\u27s degree of success. This thesis develops a response to these propaganda devices as presents suggestions about the advantages and disadvantages of each technique as it relates to advertising. The research yielded the glittering generalities device as the most successful propaganda device and found the card-stacking device to be the least successful

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16INK4a expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of endogenous nucleotides (EN) and nucleos(t)ide reverse transcriptase inhibitors (NRTIs). This study expands on these findings by determining whether inflammation is contributing to the association of p16INK4a expression with intracellular metabolite (IM) exposure and endogenous nucleotide concentrations

MP757: Eastern Regional Potato Trials 2005: Summary of NE1014 Regional Project Field Testing of New Potato Clones

The objectives of this regional potato trial are (1) to develop pest-resistant, early-maturing, long-dormant potato varieties that will process from cold storage; (2) to evaluate new and specialty variet­ies developed in the Northeast; (3) to determine climatic effects on performance to develop pre­dictive models for potato improvement; and (4) determine heritability/linkage relationships and improve the genetic base of tetraploid cultivated varieties. The results presented in this report reflect a portion of the activity directed toward objectives 1, 2 and 3.https://digitalcommons.library.umaine.edu/aes_miscpubs/1018/thumbnail.jp

Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16INK4a expression in subjects on combination therapy

HIV may amplify immunologic, physiologic, and functional changes of aging. We determined associations of frailty phenotype, a T-cell senescence marker (p16INK4a expression), age, and demographics with exposures of the intracellular metabolites (IM) and endogenous nucleotides (EN) of tenofovir/emtricitabine (TFV/FTC), efavirenz (EFV), atazanavir (ATV), and ritonavir (RTV)

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16^INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

<div><p>Objectives</p><p>As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16^INK4a expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of endogenous nucleotides (EN) and nucleos(t)ide reverse transcriptase inhibitors (NRTIs). This study expands on these findings by determining whether inflammation is contributing to the association of p16^INK4a expression with intracellular metabolite (IM) exposure and endogenous nucleotide concentrations.</p><p>Methods</p><p>Samples from 73 HIV-infected adults receiving daily tenofovir/emtricitabine (TFV/FTC) with either efavirenz (EFV) or atazanavir/ritonavir (ATV/r) were tested for p16^INK4a expression, and plasma cytokine and intracellular drug concentrations. Associations between p16^INK4a expression and cytokine concentrations were assessed using maximum likelihood methods, and elastic net regression was applied to assess whether cytokines were predictive of intracellular metabolite/endogenous nucleotide exposures.</p><p>Results</p><p>Enrolled participants had a median age of 48 years (range 23–73). There were no significant associations between p16^INK4a expression and cytokines. Results of the elastic net regression showed weak relationships between IL-1Ra and FTC-triphosphate and deoxyadenosine triphosphate exposures, and MIP-1β, age and TFV-diphosphate exposures.</p><p>Conclusions</p><p>In this clinical evaluation, we found no relationships between p16^INK4a expression and cytokines, or cytokines and intracellular nucleotide concentrations. While inflammation is known to play a role in this population, it is not a major contributor to the p16^INK4a association with decreased IM/EN exposures in these HIV-infected participants.</p></div

Boxplots of measured cytokine concentrations.

<p>Boxplots of measured cytokine concentrations.</p

Scatterplots of p16^INK4a expression versus cytokine concentrations.

<p>Observations with quantifiable cytokine concentrations are displayed as blue circles; concentrations below the LLQ are displayed as red + symbols. Cytokine concentrations and p16^INK4a expression were natural-log transformed and log₂ transformed, respectively. A descriptive LOESS curve is plotted handling below LLQ values as observed. Correlation estimates were less than or equal to 0.22 for all associations (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0168709#pone.0168709.t001" target="_blank">Table 1</a>). LLQ, lower limit of quantification.</p