Paclitaxel, Epirubicin and Capecitabine (TEX) as First-Line Treatment for Metastatic Breast Cancer: a Pilot Phase I/II Feasibility Study

Thirteen patients with untreated metastatic breast cancer received epirubicin 60 mg/m2, paclitaxel 155 mg/m2 (both day 1) and capecitabine 665 mg/m2 twice daily (days 1–14) every 21 days, with intra-patient dose escalation/reduction. Grade 3/4 events were infrequent. Nine patients (69%) achieved an objective response. Median time to progression and overall survival were 6.6 and 23.5 months, respectively

Quadrature Control-Bounded ADCs

In this paper, the design flexibility of the control-bounded analog-to-digital converter principle is demonstrated by considering band-pass analog-to-digital conversion. We show how a low-pass control-bounded analog-to-digital converter can be translated into a band-pass version where the guaranteed stability, converter bandwidth, and signal-to-noise ratio are preserved while the center frequency for conversion can be positioned freely. The proposed converter is validated with behavioral simulations for a variety of filter orders, notch-filter frequencies, and oversampling ratios. Finally, robustness against component variations is demonstrated by Monte Carlo simulations.Comment: 5 pages, 6 figures, submitted to ISCAS 202

A Control-Bounded Quadrature Leapfrog ADC

In this paper, the design flexibility of the control-bounded analog-to-digital converter principle is demonstrated. A band-pass analog-to-digital converter is considered as an application and case study. We show how a low-pass control-bounded analog-to-digital converter can be translated into a band-pass version where the guaranteed stability, converter bandwidth, and signal-to-noise ratio are preserved while the center frequency for conversion can be positioned freely. The proposed converter is validated with behavioral simulations on several filter orders, center frequencies, and oversampling ratios. Additionally, we consider an op-amp circuit realization where the effects of first-order op-amp non-idealities are shown. Finally, robustness against component variations is demonstrated by Monte Carlo simulations.Comment: 13 pages and 16 figure

Is our Sun a Singleton?

Most stars are formed in a cluster or association, where the number density of stars can be high. This means that a large fraction of initially-single stars will undergo close encounters with other stars and/or exchange into binaries. We describe how such close encounters and exchange encounters can affect the properties of a planetary system around a single star. We define a singleton as a single star which has never suffered close encounters with other stars or spent time within a binary system. It may be that planetary systems similar to our own solar system can only survive around singletons. Close encounters or the presence of a stellar companion will perturb the planetary system, often leaving planets on tighter and more eccentric orbits. Thus planetary systems which initially resembled our own solar system may later more closely resemble some of the observed exoplanet systems.Comment: 2 pages, 1 figure. To be published in the proceedings of IAUS246 "Dynamical Evolution of Dense Stellar Systems". Editors: E. Vesperini (Chief Editor), M. Giersz, A. Sill

The origin of very wide binary systems

The majority of stars in the Galactic field and halo are part of binary or multiple systems. A significant fraction of these systems have orbital separations in excess of thousands of astronomical units, and systems wider than a parsec have been identified in the Galactic halo. These binary systems cannot have formed through the 'normal' star-formation process, nor by capture processes in the Galactic field. We propose that these wide systems were formed during the dissolution phase of young star clusters. We test this hypothesis using N-body simulations of evolving star clusters and find wide binary fractions of 1-30%, depending on initial conditions. Moreover, given that most stars form as part of a binary system, our theory predicts that a large fraction of the known wide 'binaries' are, in fact, multiple systems.Comment: 4 pages, 1 figure, to appear in the proceedings of IAU Symposium 266, eds. R. de Grijs & J.R.D. Lepin

Evidence for electron transfer between graphene and non‐covalently bound π‐systems

Hybridizing graphene and molecules possess a high potential for developing materials for new applications. However, new methods to characterize such hybrids must be developed. Herein, the wet‐chemical non‐covalent functionalization of graphene with cationic π‐systems is presented and the interaction between graphene and the molecules is characterized in detail. A series of tricationic benzimidazolium salts with various steric demand and counterions was synthesized, characterized and used for the fabrication of graphene hybrids. Subsequently, the doping effects were studied. The molecules are adsorbed onto graphene and studied by Raman spectroscopy, XPS as well as ToF‐SIMS. The charged π‐systems show a p‐doping effect on the underlying graphene. Consequently, the tricationic molecules are reduced through a partial electron transfer process from graphene, a process which is accompanied by the loss of counterions. DFT calculations support this hypothesis and the strong p‐doping could be confirmed in fabricated monolayer graphene/hybrid FET devices. The results are the basis to develop sensor applications, which are based on analyte/molecule interactions and effects on doping