889 research outputs found
Anticorrelation between Ion Acceleration and Nonlinear Coherent Structures from Laser-Underdense Plasma Interaction
In laser-plasma experiments, we observed that ion acceleration from the
Coulomb explosion of the plasma channel bored by the laser, is prevented when
multiple plasma instabilities such as filamentation and hosing, and nonlinear
coherent structures (vortices/post-solitons) appear in the wake of an
ultrashort laser pulse. The tailoring of the longitudinal plasma density ramp
allows us to control the onset of these insabilities. We deduced that the laser
pulse is depleted into these structures in our conditions, when a plasma at
about 10% of the critical density exhibits a gradient on the order of 250
{\mu}m (gaussian fit), thus hindering the acceleration. A promising
experimental setup with a long pulse is demonstrated enabling the excitation of
an isolated coherent structure for polarimetric measurements and, in further
perspectives, parametric studies of ion plasma acceleration efficiency.Comment: 4 pages, 5 figure
Femtosecond x rays from laser-plasma accelerators
Relativistic interaction of short-pulse lasers with underdense plasmas has
recently led to the emergence of a novel generation of femtosecond x-ray
sources. Based on radiation from electrons accelerated in plasma, these sources
have the common properties to be compact and to deliver collimated, incoherent
and femtosecond radiation. In this article we review, within a unified
formalism, the betatron radiation of trapped and accelerated electrons in the
so-called bubble regime, the synchrotron radiation of laser-accelerated
electrons in usual meter-scale undulators, the nonlinear Thomson scattering
from relativistic electrons oscillating in an intense laser field, and the
Thomson backscattered radiation of a laser beam by laser-accelerated electrons.
The underlying physics is presented using ideal models, the relevant parameters
are defined, and analytical expressions providing the features of the sources
are given. Numerical simulations and a summary of recent experimental results
on the different mechanisms are also presented. Each section ends with the
foreseen development of each scheme. Finally, one of the most promising
applications of laser-plasma accelerators is discussed: the realization of a
compact free-electron laser in the x-ray range of the spectrum. In the
conclusion, the relevant parameters characterizing each sources are summarized.
Considering typical laser-plasma interaction parameters obtained with currently
available lasers, examples of the source features are given. The sources are
then compared to each other in order to define their field of applications.Comment: 58 pages, 41 figure
Observation of longitudinal and transverse self-injections in laser-plasma accelerators
Laser-plasma accelerators can produce high quality electron beams, up to
giga-electronvolts in energy, from a centimeter scale device. The properties of
the electron beams and the accelerator stability are largely determined by the
injection stage of electrons into the accelerator. The simplest mechanism of
injection is self-injection, in which the wakefield is strong enough to trap
cold plasma electrons into the laser wake. The main drawback of this method is
its lack of shot-to-shot stability. Here we present experimental and numerical
results that demonstrate the existence of two different self-injection
mechanisms. Transverse self-injection is shown to lead to low stability and
poor quality electron beams, because of a strong dependence on the intensity
profile of the laser pulse. In contrast, longitudinal injection, which is
unambiguously observed for the first time, is shown to lead to much more stable
acceleration and higher quality electron beams.Comment: 7 pages, 7 figure
Probing electron acceleration and X-ray emission in laser-plasma accelerator
While laser-plasma accelerators have demonstrated a strong potential in the
acceleration of electrons up to giga-electronvolt energies, few experimental
tools for studying the acceleration physics have been developed. In this paper,
we demonstrate a method for probing the acceleration process. A second laser
beam, propagating perpendicular to the main beam is focused in the gas jet few
nanosecond before the main beam creates the accelerating plasma wave. This
second beam is intense enough to ionize the gas and form a density depletion
which will locally inhibit the acceleration. The position of the density
depletion is scanned along the interaction length to probe the electron
injection and acceleration, and the betatron X-ray emission. To illustrate the
potential of the method, the variation of the injection position with the
plasma density is studied
Tuning the electron energy by controlling the density perturbation position in laser plasma accelerators
A density perturbation produced in an underdense plasma was used to improve
the quality of electron bunches produced in the laser-plasma wakefield
acceleration scheme. Quasi-monoenergetic electrons were generated by controlled
injection in the longitudinal density gradients of the density perturbation. By
tuning the position of the density perturbation along the laser propagation
axis, a fine control of the electron energy from a mean value of 60 MeV to 120
MeV has been demonstrated with a relative energy-spread of 15 +/- 3.6%,
divergence of 4 +/- 0.8 mrad and charge of 6 +/- 1.8 pC.Comment: 7 pages, 8 figure
Betatron emission as a diagnostic for injection and acceleration mechanisms in laser-plasma accelerators
Betatron x-ray emission in laser-plasma accelerators is a promising compact
source that may be an alternative to conventional x-ray sources, based on large
scale machines. In addition to its potential as a source, precise measurements
of betatron emission can reveal crucial information about relativistic
laser-plasma interaction. We show that the emission length and the position of
the x-ray emission can be obtained by placing an aperture mask close to the
source, and by measuring the beam profile of the betatron x-ray radiation far
from the aperture mask. The position of the x-ray emission gives information on
plasma wave breaking and hence on the laser non-linear propagation. Moreover,
the measurement of the longitudinal extension helps one to determine whether
the acceleration is limited by pump depletion or dephasing effects. In the case
of multiple injections, it is used to retrieve unambiguously the position in
the plasma of each injection. This technique is also used to study how, in a
capillary discharge, the variations of the delay between the discharge and the
laser pulse affect the interaction. The study reveals that, for a delay
appropriate for laser guiding, the x-ray emission only occurs in the second
half of the capillary: no electrons are injected and accelerated in the first
half.Comment: 8 pages, 6 figures. arXiv admin note: text overlap with
arXiv:1104.245
Practical guide to genetic screening for inherited eye diseases
Genetic eye diseases affect around one in 1000 people worldwide for which the molecular aetiology remains unknown in the majority. The identification of disease-causing gene variant(s) allows a better understanding of the disorder and its inheritance. There is now an approved retinal gene therapy for autosomal recessive RPE65-retinopathy, and numerous ocular gene/mutation-targeted clinical trials underway, highlighting the importance of establishing a genetic diagnosis so patients can fully access the latest research developments and treatment options. In this review, we will provide a practical guide to managing patients with these conditions including an overview of inheritance patterns, required pre- and post-test genetic counselling, different types of cytogenetic and genetic testing available, with a focus on next generation sequencing using targeted gene panels, whole exome and genome sequencing. We will expand on the pros and cons of each modality, variant interpretation and options for family planning for the patient and their family. With the advent of genomic medicine, genetic screening will soon become mainstream within all ophthalmology subspecialties for prevention of disease and provision of precision therapeutics
A bremsstrahlung gamma-ray source based on stable ionization injection of electrons into a laser wakefield accelerator
Laser wakefield acceleration permits the generation of ultra-short,
high-brightness relativistic electron beams on a millimeter scale. While those
features are of interest for many applications, the source remains constraint
by the poor stability of the electron injection process. Here we present
results on injection and acceleration of electrons in pure nitrogen and argon.
We observe stable, continuous ionization-induced injection of electrons into
the wakefield for laser powers exceeding a threshold of 7 TW. The beam charge
scales approximately linear with the laser energy and is limited by beam
loading. For 40 TW laser pulses we measure a maximum charge of almost 1 nC per
shot, originating mostly from electrons of less than 10 MeV energy. The
relatively low energy, the high charge and its stability make this source
well-suited for applications such as non-destructive testing. Hence, we
demonstrate the production of energetic radiation via bremsstrahlung conversion
at 1 Hz repetition rate. In accordance with Geant4 Monte-Carlo simulations, we
measure a gamma-ray source size of less than 100 microns for a 0.5 mm tantalum
converter placed at 2 mm from the accelerator exit. Furthermore we present
radiographs of image quality indicators
Demonstration of the synchrotron-type spectrum of laser-produced Betatron radiation
Betatron X-ray radiation in laser-plasma accelerators is produced when
electrons are accelerated and wiggled in the laser-wakefield cavity. This
femtosecond source, producing intense X-ray beams in the multi kiloelectronvolt
range has been observed at different interaction regime using high power laser
from 10 to 100 TW. However, none of the spectral measurement performed were at
sufficient resolution, bandwidth and signal to noise ratio to precisely
determine the shape of spectra with a single laser shot in order to avoid shot
to shot fluctuations. In this letter, the Betatron radiation produced using a
80 TW laser is characterized by using a single photon counting method. We
measure in single shot spectra from 8 to 21 keV with a resolution better than
350 eV. The results obtained are in excellent agreement with theoretical
predictions and demonstrate the synchrotron type nature of this radiation
mechanism. The critical energy is found to be Ec = 5.6 \pm 1 keV for our
experimental conditions. In addition, the features of the source at this energy
range open novel perspectives for applications in time-resolved X-ray science.Comment: 5 pages, 4 figure
Single shot phase contrast imaging using laser-produced Betatron x-ray beams
Development of x-ray phase contrast imaging applications with a laboratory
scale source have been limited by the long exposure time needed to obtain one
image. We demonstrate, using the Betatron x-ray radiation produced when
electrons are accelerated and wiggled in the laser-wakefield cavity, that a
high quality phase contrast image of a complex object (here, a bee), located in
air, can be obtained with a single laser shot. The Betatron x-ray source used
in this proof of principle experiment has a source diameter of 1.7 microns and
produces a synchrotron spectrum with critical energy E_c=12.3 +- 2.5 keV and
10^9 photons per shot in the whole spectrum.Comment: 3 pages, 3 figure
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