A Simple Continuous Titration Technique for Determining pK Values of Protonated Ligands

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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IMPURITIES FROM OLMESARTAN MEDOXIMIL AND HYDROCHLOROTHIAZIDE TABLET

Objective: To develop and validate stability indicating RP-HPLC gradient method for simultaneous estimation of impurities and degradation products from Olmesartan Medoximil and Hydrochlorothiazide tablet.Methods: The chromatographic separation was achieved by using Inertsil ODS (250 mm x 4.6 mm, 5μ) column. The mobile phase-A consists of 0.01M potassium dihydrogen phosphatebuffer pH 3.2 adjusted using orthophosphoric acids and acetonitrile as mobile phase-B. The flow rate was 1 ml/min, and chromatograms extracted at wavelength 225 nm.Results: The method was found linear from LOQ to 0.4% level with respect to target concentrations of Olmesartan Medoximil (1.6 mg/ml) and Hydrochlorothiazide (0.5 m/ml) for all impurities, with correlation coefficient found greater than 0.99. The method found robust in all deliberate variations of method parameters as a resolution between adjacent peaks found greater than 2.0. The % RSD results for precision and intermediate precision found less than 5.0%.Conclusion: The proposed analytical method was found to be robust, stability indicating and can be used for estimation of impurities and degradation products of Olmesartan Medoximil and Hydrochlorothiazide from tablet dosage form.Keywords: Stability indicating, RP-HPLC, ICH, Olmesartan Medoximil and Hydrochlorothiazid

Review on Different Searchable Encryption Schemes for Cloud Computing

Heavily available online data and its day to day expansion is need to be focus to store and retrieve it properly. This enforces the data owners tend to store their data into the cloud. This also suggest to handle the data properly and so release the burden of data storage and maintenance. But as the data owner and user, cloud server are not belong to same trusted domain, this may cause the outsourced to the risk. This enforce us to set the policy to avoid such risk factor. This gives us study scope to fine the different techniques to overcome such issue observed by different author. In this paper we try to underline the different solution, its limitation and results they achieved for retrieval of data securely and within less time. Definitely from this we will be able to propose our own solution

ROLE OF SOMVALK KASHAY ASTHAPAN BASTI IN PRAMEHA W.S.R TO (DIABETES MELLITUS TYPE 2)

The disease diabetes currently affects more than 62 million people which is more than 7.1% of India’s adult population. The prevalence rate of diabetes in urban and rural areas is 10.3% and 6.2% respectively. The Aim of the study is standardization of the method of preparation and administration of Somvalk Kashay Asthapan Basti and Somvalk Siddha Taila Anuvasan Basti. Two groups Group A (Trial Group) 50 patients is given Somvalkkashayasthapan Basti, and Somvalk siddhataila anuvasanbasti along with Metformin for 12 days and Group B (Control Group) 50 patients is given oral hypoglycemic drug and Metformin will be given according to the dosage 12 days. Group A showed moderate improvement, while Group B showed no improvement. The overall result obtained in the present study  shows 65% improvement in trial group which is moderate improvement according to the overall assessment criteria, whereas there was only 18% improvement in the control group which falls within unimproved category according to the overall assessment criteria. The trial drug in the study i.e., Somvalk kasha Asthapanbasti has been proved significantly effective in symptoms like Polyuria, polydipsia, polyphagia and urine sugar. It has shown moderate effects on the symptoms like numbness and tingling. It has shown mild improvement in parameters of BSL- Fasting and BSL- PP

Artificial Neural Network Based Automatic Number Plate Recognition System

This paper deals with Automatic Number Plate Recognition (ANPR) using Artificial Neural Network. The ANPR system includes steps like pre-processing, localization, character segmentation and character recognition. The developed system first detects the vehicle and then captures the vehicle image. The captured image is pre-processed in order to enhance it for further processing. In localization the license plate region is located and cropped from the complete image. In character segmentation images of individual alpha-numeric characters are extracted from the localized plate. In this paper, we proposed Neural Network based character recognition. Scaled Conjugate Gradient Backpropogation algorithm is used for training the neural network. This system is implemented in MATLAB R2014b

Coordination in Distributed Agile Software Development: A Systematic Review

In order to decrease the consumer return transaction cost, e-commerce platform Alibaba invited an insurance company to develop a new type of insurance to compensate consumers for returns, which is called return-freight insurance. The new insurance has resulted in online return\u27s explosive growth. However, some online retailers still choose to offer complimentary return-freight insurance to signal their products\u27 quality. Using signaling theory, we build a conceptual economic model to explore what kind of online retailer should adopt this strategy under incomplete information. Based on the fact that each product\u27s return probability, profit, and insurance compensation are different, our main results show the separating equilibria, where only high-quality online retailers will offer complimentary return-freight insurance. Interestingly, return-freight insurance profit and compensation play different roles in the signal effect. The insurance premium plays a deep role while the compensation plays at the surface, because consumers could only observe the compensation when purchasing

Avoid duplicate key overheads for same data in storage

De-duplication is a technique used to weaken the amount of storage needed by service providers. Now a day the most originating challenge is to perform secure de-duplication in cloud storage. Although convergent encryption has been extensively adopted for secure de-duplication, a demanding issue of making convergent encryption practical is to efficiently and reliably managea massive number of convergent keys. We first introduce a baseline approach in which each user holds an autonomous master key forencrypting the convergent keys and outsourcing them to the server. As a proof of concept, encompass the implementation framework of proposed authorized duplicate check scheme and conduct experiments using these prototype. In proposed system involve authorized duplicate checkscheme sustain minimal overhead compared to normal operations.De-duplication is one of important data compression techniques for eliminating duplicate copies of repeating data. For that purpose Authorized duplication check system is used. This paper addresses problem of privacy preserving de-duplication in cloud computing and introduce a new de-duplication system supporting for Differential Authorization, Authorized Duplicate Check, Unfeasiblity of file token/duplicate-check token, In distinguishability of file token/duplicate-check token, Data affinity.In this project we are presenting the certified data de-duplication toprotect the data security by counting differential privileges of users in the duplicate check.Different new de-duplication constructions presented for supporting authorized duplicate check

Evaluation of Seed Transmission of Rhizoctonia solani and Seed Mycoflora of Ajwain

In vitro study was conducted Department of Plant Pathology, Rajasthan College of Agriculture, Udaipur (Rajasthan) and evaluated the seed transmission of R. solani from the seeds of eight popular cultivars of ajwain viz., Ajmer Ajwain-1, Ajmer Ajwain-2, Ajmer Ajwain-93, Pratap Ajwain, Lam selection-1, Gujarat Ajwain-1, Azad Ajwain and local cultivar. It was found that maximum recovery of the pathogens was from local cultivar and Ajmer Ajwain-93 exhibited lowest recovery of pathogens. It was also found in this study that there some differential results in recovery of R. solani from seeds of cv. Gujarat Ajwain-1 and cv. Azad Ajwain. Seed samples were collected and results revealed that in all seed mycoflora were detected in both blotter and agar plate test methods from almost all the seed samples and these fungi were Aspergillus niger, Aspergillus flavus, Aspergillus ochraceeous, Alternaria alternata, Rhizopus oryzae, Rhizoctonia solani, Dreschslera australiensis and Fusarium sporotrichioides

Recurrent breast abscess due to Salmonella paratyphi A:an unusual case

Bacterial mastitis is the most common variety of mastitis and is often caused by Staphylococcus aureus. Chronic mastitis is usually seen as a complication of tuberculosis & syphilis. A 31-year-old female presented with lump in the right breast for the past two years with pain for the past 15 days and discharge for the past two to three days. On examination, the lump was measured and was approximately 4x4 cm in size with a discharging sinus just lateral to the areola. No regional lymphadenopathy was noticed. A clinical diagnosis of “Lump in the right breast” with sinus probably due to tuberculosis was made. The lump had been excised surgically. Salmonella paratyphi A was isolated after repeated culture. She had responded to ceftriaxone, hence, unnecessary use of anti-tubercular drugs could be avoided. In chronic mastitis and breast abscess Salmonella species should be considered as one of the etiological agents.

Experimental evidence for fast cluster formation of chain oxygen vacancies in YBa2Cu3O7-d being at the origin of the fishtail anomaly

We report on three different and complementary measurements, namely magnetisation measurements, positron annihilation spectroscopy and NMR measurements, which give evidence that the formation of oxygen vacancy clusters is on the origin of the fishtail anomaly in YBa2Cu3O7-d. While in the case of YBa2Cu3O7.0 the anomaly is intrinsically absent, it can be suppressed in the optimally doped state where vacancies are present. We therefore conclude that the single vacancies or point defects can not be responsible for this anomaly but that clusters of oxygen vacancies are on its origin.Comment: 10 pages, 4 figures, submitted to PR