Luminosity functions of Lyman-alpha emitters at z=6.5, and z=5.7: evidence against reionization at z=6

Lyman-alpha emission from galaxies should be suppressed completely or partially at redshifts beyond reionization. Without knowing the instrinsic properties of galaxies at z = 6.5, this attenuation is hard to infer in any one source, but can be infered from a comparison of luminosity functions of lyman-alpha emitters at redshifts just before and after reionization. We combine published surveys of widely varying depths and areas to construct luminosity functions at z=6.5 and 5.7, where the characteristic luminosity L_star and density phi_star are well constrained while the faint-end slope of the luminosity function is essentially unconstrained. Excellent consistency is seen in all but one published result. We then calculate the likelihood of obtaining the z=6.5 observations given the z=5.7 luminosity function with (A) no evolution and (B) an attenuation of a factor of three. Hypothesis (A) gives an acceptable likelihood while (B) does not. This indicates that the z=6.5 lyman-alpha lines are not strongly suppressed by a neutral intergalactic medium and that reionization was largely complete at z = 6.5.Comment: Submitted to Astrophysical Journal Letter

Dynamics of the Kuiper Belt

Our current knowledge of the dynamical structure of the Kuiper Belt is reviewed here. Numerical results on long term orbital evolution and dynamical mechanisms underlying the transport of objects out of the Kuiper Belt are discussed. Scenarios about the origin of the highly non-uniform orbital distribution of Kuiper Belt objects are described, as well as the constraints these provide on the formation and long term dynamical evolution of the outer Solar system. Possible mechanisms include an early history of orbital migration of the outer planets, a mass loss phase in the outer Solar system and scattering by large planetesimals. The origin and dynamics of the scattered component of the Kuiper Belt is discussed. Inferences about the primordial mass distribution in the trans-Neptune region are reviewed. Outstanding questions about Kuiper Belt dynamics are listed.Comment: 22 pages plus 8 figures added footnote, figure

Exercise and hypertrophic cardiomyopathy: Two incompatible entities?

A greater understanding of the pathogenic mechanisms underpinning hypertrophic cardiomyopathy (HCM) has translated to improved medical care and better survival of affected individuals. Historically these patients were considered to be at high risk of sudden cardiac death (SCD) during exercise; therefore, exercise recommendations were highly conservative and promoted a sedentary life style. There is emerging evidence that suggests that exercise in HCM has a favorable effect on cardiovascular remodeling and moderate exercise programs have not raised any safety concerns. Furthermore, individuals with HCM have a similar burden of atherosclerotic risk factors as the general population in whom exercise has been associated with a reduction in myocardial infarction, stroke, and heart failure, especially among those with a high-risk burden. Small studies revealed that athletes who choose to continue with regular competition do not demonstrate adverse outcomes when compared to those who discontinue sport, and active individuals implanted with an implantable cardioverter defibrillator do not have an increased risk of appropriate shocks or other adverse events. The recently published exercise recommendations from the European Association for Preventative Cardiology account for more contemporary evidence and adopt a more liberal stance regarding competitive and high intensity sport in individuals with low-risk HCM. This review addresses the issue of exercise in individuals with HCM, and explores current evidence supporting safety of exercise in HCM, potential caveats, and areas of further research

Dynamic attentional modulation of vision across space and time after right hemisphere stroke and in ageing

This article is available open access and is shared under a Creative Commons licence (http://creativecommons.org/licenses/by/3.0/). Copyright @ 2012 Elsevier Ltd.Introduction - Attention modulates the availability of sensory information to conscious perception. In particular, there is evidence of pathological, spatial constriction of the effective field of vision in patients with right hemisphere damage when a central task exhausts available attentional capacity. In the current study we first examined whether this constriction might be modulated across both space and time in right hemisphere stroke patients without neglect. Then we tested healthy elderly people to determine whether non-pathological ageing also leads to spatiotemporal impairments of vision under conditions of high attention load. Methods - Right hemisphere stroke patients completed a task at fixation while attempting to discriminate letters appearing in the periphery. Attentional load of the central task was modulated by increasing task difficulty. Peripheral letters appeared simultaneously with the central task or at different times (stimulus onset asynchronies, SOAs) after it. In a second study healthy elderly volunteers were tested with a modified version of this paradigm. Results - Under conditions of high attention load right hemisphere stroke patients have a reduced effective visual field, over a significantly extended ‘attentional blink’, worse for items presented to their left. In the second study, older participants were unable to discriminate otherwise salient items across the visual field (left or right) when their attention capacity was loaded on the central task. This deficit extended temporally, with peripheral discrimination ability not returning to normal for up to 450 msec. Conclusions - Dynamically tying up attention resources on a task at fixation can have profound effects in patient populations and in normal ageing. These results demonstrate that items can escape conscious detection across space and time, and can thereby impact significantly on visual perception in these groups.The European Commission, Brunel University and the Wellcome Trust

The synthesis, characterization and thermal chemistry of modified norbornenyl PMR endcaps

As part of a program to further the understanding of the polymerization of Nadic-Endcapped PMR systems, a series of model Norbornenyl-Imides has been synthesized and their thermal behavior explored. Their syntheses and characterizations as well as their rearrangement and polymerization chemistry are described. Monomer isomerization at temperatures as low as 125 C and oligomer formation at somewhat higher temperatures are observed. Approximate relative rates for competing isomerization pathways are established and some information is obtained about the details of oligomer formation. The relationship of this data to current PMR systems is briefly discussed

Ada software productivity prototypes: A case study

A case study of the impact of Ada on a Command and Control project completed at the Jet Propulsion Laboratory (JPL) is given. The data for this study was collected as part of a general survey of software costs and productivity at JPL and other NASA sites. The task analyzed is a successful example of the use of rapid prototyping as applied to command and control for the U.S. Air Force and provides the U.S. Air Force Military Airlift Command with the ability to track aircraft, air crews and payloads worldwide. The task consists of a replicated database at several globally distributed sites. The local databases at each site can be updated within seconds after changes are entered at any one site. The system must be able to handle up to 400,000 activities per day. There are currently seven sites, each with a local area network of computers and a variety of user displays; the local area networks are tied together into a single wide area network. Using data obtained for eight modules, totaling approximately 500,000 source lines of code, researchers analyze the differences in productivities between subtasks. Factors considered are percentage of Ada used in coding, years of programmer experience, and the use of Ada tools and modern programming practices. The principle findings are the following. Productivity is very sensitive to programmer experience. The use of Ada software tools and the use of modern programming practices are important; without such use Ada is just a large complex language which can cause productivity to decrease. The impact of Ada on development effort phases is consistent with earlier reports at the project level but not at the module level

Neptune's Migration into a Stirred-Up Kuiper Belt: A Detailed Comparison of Simulations to Observations

Nbody simulations are used to examine the consequences of Neptune's outward migration into the Kuiper Belt, with the simulated endstates being compared rigorously and quantitatively to the observations. These simulations confirm the findings of Chiang et al. (2003), who showed that Neptune's migration into a previously stirred-up Kuiper Belt can account for the Kuiper Belt Objects (KBOs) known to librate at Neptune's 5:2 resonance. We also find that capture is possible at many other weak, high-order mean motion resonances, such as the 11:6, 13:7, 13:6, 9:4, 7:3, 12:5, 8:3, 3:1, 7:2, and the 4:1. The more distant of these resonances, such as the 9:4, 7:3, 5:2, and the 3:1, can also capture particles in stable, eccentric orbits beyond 50 AU, in the region of phase space conventionally known as the Scattered Disk. Indeed, 90% of the simulated particles that persist over the age of the Solar System in the so-called Scattered Disk zone never had a close encounter with Neptune, but instead were promoted into these eccentric orbits by Neptune's resonances during the migration epoch. This indicates that the observed Scattered Disk might not be so scattered. This model also produced only a handful of Centaurs, all of which originated at Neptune's mean motion resonances in the Kuiper Belt. We also report estimates of the abundances and masses of the Belt's various subpopulations (e.g., the resonant KBOs, the Main Belt, and the so-called Scattered Disk), and also provide upper limits on the abundance of Centaurs and Neptune's Trojans, as well as upper limits on the sizes and abundances of hypothetical KBOs that might inhabit the a>50 AU zone.Comment: 60 pages, 16 figures. Accepted for publication in the Astronomical Journa

The impact of private sector provision on equitable provision of coronary revascularisation

Objective: To investigate the impact of including private sector data on assessments of equity of coronary revascularisation provision using NHS data only. Design: Analyses of Hospital Episodes Statistics and private sector data by age, sex, and PCT of residence. For each PCT, the share of London's total population and revascularisations (all admissions, NHS-funded, and privately-funded admissions) were calculated. GINI coefficients were derived to provide an index of inequality across sub-populations, with parametric bootstrapping to estimate confidence intervals. Setting: London Participants London residents undergoing coronary revascularisation April 2001 - December 2003. Intervention Coronary artery bypass graft or angioplasty Main outcome measures: Directly-standardised revascularisation rates, GINI coefficients. Results: NHS-funded age-standardised revascularisation rates varied from 95.2 to 193.9 per 100,000 and privately funded procedures from 7.6 to 57.6. Although the age distribution did not vary by funding, the proportion of revascularisations among women that were privately funded (11.0%) was lower than among men (17.0%). Privately funded rates were highest in PCTs with the lowest death rates (p=0.053). NHS-funded admission rates were not related to deprivation nor age-standardised deaths rates from coronary heart disease. Privately-funded admission rates were lower in more deprived PCTs. NHS provision was significantly more egalitarian (Gini coefficient 0.12) than the private sector (0.35). Including all procedures was significantly less equal (0.13) than NHS funded care alone. Conclusion: Private provision exacerbates geographical inequalities. Those responsible for commissioning care for defined populations must have access to consistent data on provision of treatment wherever it takes place