Investigations And Management Of Epizootic Plague At Ice House Reservoir, Eldorado National Forest, California, 1994 And 1995

The occurrence of plague (Yersinia pestic) at Ice House Reservoir in 1994 and 1995 was characteristic of widespread epizootics in high use recreational areas of California. Staff of the Vector-Borne Disease Section investigated these epizootics and found dense populations of plague susceptible California ground squirrels (Spermophilus beecheyi) with high numbers of fleas, primarily Diamanus montanus, the most important plague vector. This combination indicated a high risk of plague exposure to campground users. A non-fatal human case of plague, contracted at Mountain Camp II, was reported after the initial epizootic investigation. The patient\u27s exposure occurred prior to the reporting of the epizootic die-off among the California ground squirrels. The plague investigation included direct observations, animal trapping, and laboratory testing of rodent carcasses, sera, and fleas. Plague management and prevention included flea control with 2% Diazinon dust and rodent population reduction using 1% zinc phosphide treated grain. Evaluation of the 1994 applications indicated a successful reduction of rodents and fleas. However, the need for an ongoing management program was emphasized in 1995 when the plague epizootic continued. Intrusion of plague infected rodents and their fleas necessitated a 1995 treatment in the four campgrounds involved

The principles and practice of open fracture care, 2018

The principles of open fracture management are to manage the overall injury and specifically prevent primary contamination becoming frank infection. The surgical management of these complex injuries includes debridement and lavage of the open wound with combined bony and soft tissue reconstruction. Good results depend on early high quality definitive surgery usually with early stable internal fixation and associated soft tissue repair. While all elements of the surgical principles are very important and depend on each other for overall success the most critical element appears to be achieving very early healthy soft tissue cover. As the injuries become more complex this involves progressively more complex soft tissue reconstruction and may even requiring urgent free tissue transfer requiring close co-operative care between orthopaedic and plastic surgeons. Data suggests that the best results are obtained when the whole surgical reconstruction is completed within 48-72 h

Tuning the effects of Landau-level mixing on anisotropic transport in quantum Hall systems

Electron-electron interactions in half-filled high Landau levels in two-dimensional electron gases in a strong perpendicular magnetic field can lead to states with anisotropic longitudinal resistance. This longitudinal resitance is generally believed to arise from broken rotational invariance, which is indicated by charge density wave (CDW) order in Hartree-Fock calculations. We use the Hartree-Fock approximation to study the influence of externally tuned Landau level mixing on the formation of interaction induced states that break rotational invariance in two-dimensional electron and hole systems. We focus on the situation when there are two non-interacting states in the vicinity of the Fermi level and construct a Landau theory to study coupled charge density wave order that can occur as interactions are tuned and the filling or mixing are varied. We examine in detail a specific example where mixing is tuned externally through Rashba spin-orbit coupling. We calculate the phase diagram and find the possibility of ordering involving coupled striped or triangular charge density waves in the two levels. Our results may be relevant to recent transport experiments on quantum Hall nematics in which Landau-level mixing plays an important role.Comment: 25 pages, 6 figure

Triplets of Quasars at high redshift I: Photometric data

We have conducted an optical and infrared imaging in the neighbourhoods of 4 triplets of quasars. R, z', J and Ks images were obtained with MOSAIC II and ISPI at Cerro Tololo Interamerican Observatory. Accurate relative photometry and astrometry were obtained from these images for subsequent use in deriving photometric redshifts. We analyzed the homogeneity and depth of the photometric catalog by comparing with results coming from the literature. The good agreement shows that our magnitudes are reliable to study large scale structure reaching limiting magnitudes of R = 24.5, z' = 22.5, J = 20.5 and Ks = 19.0. With this catalog we can study the neighbourhoods of the triplets of quasars searching for galaxy overdensities such as groups and galaxy clusters.Comment: The paper contains 12 figures and 3 table

Diversity in the structures and ligand binding sites of nematode fatty acid and retinol binding proteins revealed by Na-FAR-1 from Necator americanus

Fatty acid and retinol binding proteins (FARs) comprise a family of unusual α-helix rich lipid binding proteins found exclusively in nematodes. They are secreted into host tissues by parasites of plants, animals and humans. The structure of a FAR protein from the free-living nematode Caenorhabditis elegans is available, but this protein (Ce-FAR-7) is from a subfamily of FARs that does not appear to be important at the host-parasite interface. We have therefore examined Na-FAR-1 from the blood-feeding intestinal parasite of humans, Necator americanus . The three dimensional structure of Na-FAR-1 in its ligand-free and ligand-bound forms, determined by nuclear magnetic resonance spectroscopy (NMR) and X-ray crystallography, respectively, reveals an a-helical fold similar to Ce-FAR-7, but Na-FAR-1 possesses a larger and more complex internal ligand binding cavity and an additional C-terminal a-helix. Titration of apo -Na-FAR-1 with oleic acid, analysed by NMR chemical shift perturbation, reveals that at least four distinct protein:ligand complexes can be formed. Na-FAR-1, and possibly other FARs, may have a wider repertoire for hydrophobic ligand binding, as confirmed here by our finding that a range of neutral and polar lipids co-purify with the bacterial recombinant protein. Finally, we show by immunohistochemistry that Na-FAR-1 is present in adult worms with a tissue distribution indicative of possible roles in nutrient acquisition by the parasite and in reproduction in the male

Aerodynamic control of NASP-type vehicles through Vortex manipulation. Volume 2: Static wind tunnel tests

Forebody Vortex Control (FVC) was explored in this research program for potential application to a NASP-type configuration. Wind tunnel tests were conducted to evaluate a number of jet blowing schemes. The configuration tested has a slender forebody and a 78 deg swept delta wing. Blowing jets were implemented on the leeward side of the forebody with small circular tubes tangential to the surface that could be directed aft, forward, or at angles in between. The effects of blowing are observed primarily in the yawing and rolling moments and are highly dependent on the jet configuration and the angle of attack. Results show that the baseline flow field, without blowing activated, is quite sensitive to the geometry differences of the various protruding jets, as well as being sensitive to the blowing, particularly in the angle of attack range where the forebody vortices are naturally asymmetric. The time lag of the flow field response to the initiation of blowing was also measured. The time response was very short, on the order of the time required for the flow disturbance to travel the distance from the nozzle to the specific airframe location of interest at the free stream velocity. Overall, results indicate that sizable yawing and rolling moments can be induced with modest blowing levels. However, direct application of this technique on a very slender forebody would require thorough wind tunnel testing to optimize the jet location and configuration