2,763 research outputs found
Statistics of football dynamics
We investigate the dynamics of football matches. Our goal is to characterize
statistically the temporal sequence of ball movements in this collective sport
game, searching for traits of complex behavior. Data were collected over a
variety of matches in South American, European and World championships
throughout 2005 and 2006. We show that the statistics of ball touches presents
power-law tails and can be described by -gamma distributions. To explain
such behavior we propose a model that provides information on the
characteristics of football dynamics. Furthermore, we discuss the statistics of
duration of out-of-play intervals, not directly related to the previous
scenario.Comment: 7 page
Anomalous diffusion and anisotropic nonlinear Fokker-Planck equation
We analyse a bidimensional nonlinear Fokker-Planck equation by considering an
anisotropic case, whose diffusion coefficients are
and with . In this
context, we also investigate two situations with the drift force
. The first one is characterized by
and the second is given by and
. In these cases, we can verify an anomalous behavior induced in
different directions by the drift force applied. The found results are exact
and exhibit, in terms of the -exponentials, functions which emerge from the
Tsallis formalism. The generalization for the -dimensional case is
discussed.Comment: 6 pages, tex fil
q-exponential, Weibull, and q-Weibull distributions: an empirical analysis
In a comparative study, the q-exponential and Weibull distributions are
employed to investigate frequency distributions of basketball baskets, cyclone
victims, brand-name drugs by retail sales, and highway length. In order to
analyze the intermediate cases, a distribution, the q-Weibull one, which
interpolates the q-exponential and Weibull ones, is introduced. It is verified
that the basketball baskets distribution is well described by a q-exponential,
whereas the cyclone victims and brand-name drugs by retail sales ones are
better adjusted by a Weibull distribution. On the other hand, for highway
length the q-exponential and Weibull distributions do not give satisfactory
adjustment, being necessary to employ the q-Weibull distribution. Furthermore,
the introduction of this interpolating distribution gives an illumination from
the point of view of the stretched exponential against inverse power law
(q-exponential with q > 1) controversy.Comment: 6 pages, Latex. To appear in Physica
Había otra vez : Lo maravilloso en María Teresa Andruetto, nuevas formas de leer en el aula
Además de su escritura específicamente literaria, Andruetto ha publicado distintos ensayos y reflexiones en torno, entre otros, al ámbito de la Literatura y la infancia y se ha configurado, también, como mediadora de lectura en talleres para niños y adolescentes. Es decir, que el “había una vez” mencionado posiciona a esta escritora desde un lugar múltiple y que atraviesa distintos planos en el ámbito de la lectura: leer para escribir, recuperar historias para ser nuevamente contadas; escribir para que esas historias sean leídas y releídas; mediar la mediación entre historia y lector y, así, contar que se cuenta. En una estructura de cajas chinas, de cuentos contados por alguien que cuenta un cuento que alguien contó, se articulan las distintas voces y dejan manifiesto este carácter recursivo y que muestra el detrás de escena, aquél que percibe, también, a quien narra.Facultad de Humanidades y Ciencias de la Educació
Analisi e modellistica dei fischi emessi dal Tursiope del Mediterraneo
Descrizione del sistema di acquisizione dati audio in banda 100 kHz.
Progetto del filtro Anti-Aliasing necessario al sistema.
Sviluppo di vari software in ambiente LabVIEW per l'acquisizione e la visualizzazione in tempo reale dei segnali registrati.
Estrazione e classificazione di fischi di Tursiope del Mediterraneo, visualizzati su spetrogramma.
Analisi e modellistica dei fischi estratti tramite stima RELAX e stima polinomiale
Inhibition of Diacylglycerol kinase alpha restores TCR-induced diacylglycerol signaling and restimulation-induced cell death in XLP1 T lymphocytes
X\u2010linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency associated with an unconstrained, life\u2010threatening expansion of CD8+ T cells following Epstein\u2010Barr virus (EBV) infection. XLP1 is caused by mutations in SAP, an adaptor protein that mediates signaling through the SLAM family receptors. SAP\u2010deficient cells exhibit impaired T cell receptor (TCR) restimulation\u2010 induced cell death (RICD), a key physiological process in maintaining lymphocyte homeostasis. We previously showed that SAP has a critical role in TCR\u2010induced inhibition of diacylglycerol kinase alpha (DGK\u3b1), which phosphorylates diacylglycerol (DAG) to phosphatidic acid, acting as a major regulator of T cell signaling. Here, we show that in SAP\u2010deficient Jurkat cells, DGK\u3b1 activity impairs immune synapse (IS) formation, MTOC reorientation and affects the integrity of DAG gradient. By taking advantage of confocal live\u2010cell imaging, we found that RNAi\u2010mediated silencing or pharmacological inhibition of DGK\u3b1 in SAP\u2010deficient cells rescues both immune synapse formation and MTOC repositioning, and the subsequent DAG accumulation at the IS. Inhibition/silencing of DGK\u3b1 was also sufficient to restore PKC\uf0e8\uf020and RasGRP1 recruitment at the immune synapse, as well as ERK1/2 activation and IL\u20102 production/IL\u20102 receptor membrane exposure in SAP knockdown primary T cells. Notably, DGK\u3b1 blockade specifically reestablished RICD in both SAP\u2010 silenced cells and XLP1 patients\u2019 T cells by restoring RSK\u2010mediated induction and phosphorylation of the pro\u2010apoptotic genes Nur77 and Nor1. Furthermore, in vivo inhibition of DGK\u3b1 prevented aberrant CD8+ T cell expansion, TNF\uf0e1\uf020and IFN\uf0e3\uf020production as well as tissue infiltration in Lymphocytic Choriomeningitis Virus\u2010infected SAP KO mice, a mouse model of XLP1. Altogether, these data demonstrates that DGK\u3b1 inhibition, by increasing localized DAG signaling at the IS, restores RICD in SAP deficient cells. In vivo, this limits the CD8+ T cell expansion and tissue damage that characterize XLP1.
Collectively, these data highlight the key role for the SAP\u2010mediated DGK\u3b1 inhibition in regulating T lymphocyte homeostasis and highlight DGK\uf0e1\uf020as an attractive therapeutic target in XLP1 patients
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