Evidence of sympathetic cooling of Na+ ions by a Na MOT in a hybrid trap

A hybrid ion-neutral trap provides an ideal system to study collisional dynamics between ions and neutrals. This system provides a general cooling method that can be applied to optically inaccessible species and can also potentially cool internal degrees of freedom. The long range polarization potentials ($V\propto-\alpha/r^4$) between ions and neutrals result in large scattering cross sections at cold temperatures, making the hybrid trap a favorable system for efficient sympathetic cooling of ions by collisions with neutral atoms. We present experimental evidence of sympathetic cooling in a hybrid trap of \ce{Na+} ions, which are closed shell and therefore do not have a laser induced atomic transition, by equal mass cold Na atoms in a magneto-optical trap (MOT).Comment: 7 figure

Ion-neutral sympathetic cooling in a hybrid linear rf Paul and magneto-optical trap

Long range polarization forces between ions and neutral atoms result in large elastic scattering cross sections, e.g., 10^6 a.u. for Na+ on Na or Ca+ on Na at cold and ultracold temperatures. This suggests that a hybrid ion-neutral trap should offer a general means for significant sympathetic cooling of atomic or molecular ions. We present SIMION 7.0 simulation results concerning the advantages and limitations of sympathetic cooling within a hybrid trap apparatus, consisting of a linear rf Paul trap concentric with a Na magneto-optical trap (MOT). This paper explores the impact of various heating mechanisms on the hybrid system and how parameters related to the MOT, Paul trap, number of ions, and ion species affect the efficiency of the sympathetic cooling

Corte e carbonização como uma alternativa ao corte e queima: estudos na Amazônia.

Neste capítulo são apresentados vários estudos realizados em Manaus cujo principal objetivo foi verificar o efeito da aplicação de carvão vegetal no manejo do Latossolo Amarelo (xanthic Ferralsol) na terra firme em Manaus - Brasil. Os estudos foram conduzidos na Estação Experimental da Embrapa Amazônia Ocidental no km 30 da Rodovia AM-010. Também é descrito uma forma de manejo indígena da fertilidade do solo pela queima e uso de fontes orgânica

High-accuracy Penning trap mass measurements with stored and cooled exotic ions

The technique of Penning trap mass spectrometry is briefly reviewed particularly in view of precision experiments on unstable nuclei, performed at different facilities worldwide. Selected examples of recent results emphasize the importance of high-precision mass measurements in various fields of physics

Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy

Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients. Methods: We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, Crohn's disease, or rheumatoid arthritis to participate. The clinical history, physical examination, brain magnetic resonance imaging (MRI), and testing of cerebrospinal fluid for JC virus DNA were used by an expert panel to evaluate patients for PML. We estimated the risk of PML in patients who completed at least a clinical examination for PML or had an MRI. Results: Of 3417 patients who had recently received natalizumab while participating in clinical trials, 3116 (91 percent) who were exposed to a mean of 17.9 monthly doses underwent evaluation for PML. Of these, 44 patients were referred to the expert panel because of clinical findings of possible PML, abnormalities on MRI, or a high plasma viral load of JC virus. No patient had detectable JC virus DNA in the cerebrospinal fluid. PML was ruled out in 43 of the 44 patients, but it could not be ruled out in one patient who had multiple sclerosis and progression of neurologic disease because data on cerebrospinal fluid testing and follow-up MRI were not available. Only the three previously reported cases of PML were confirmed (1.0 per 1000 treated patients; 95 percent confidence interval, 0.2 to 2.8 per 1000). Conclusions: A detailed review of possible cases of PML in patients exposed to natalizumab found no new cases and suggested a risk of PML of roughly 1 in 1000 patients treated with natalizumab for a mean of 17.9 months. The risk associated with longer treatment is not known

What we talk about when we talk about capacitance measured with the voltage-clamp step method

Capacitance is a fundamental neuronal property. One common way to measure capacitance is to deliver a small voltage-clamp step that is long enough for the clamp current to come to steady state, and then to divide the integrated transient charge by the voltage-clamp step size. In an isopotential neuron, this method is known to measure the total cell capacitance. However, in a cell that is not isopotential, this measures only a fraction of the total capacitance. This has generally been thought of as measuring the capacitance of the “well-clamped” part of the membrane, but the exact meaning of this has been unclear. Here, we show that the capacitance measured in this way is a weighted sum of the total capacitance, where the weight for a given small patch of membrane is determined by the voltage deflection at that patch, as a fraction of the voltage-clamp step size. This quantifies precisely what it means to measure the capacitance of the “well-clamped” part of the neuron. Furthermore, it reveals that the voltage-clamp step method measures a well-defined quantity, one that may be more useful than the total cell capacitance for normalizing conductances measured in voltage-clamp in nonisopotential cells

Well-Posedness and Symmetries of Strongly Coupled Network Equations

We consider a diffusion process on the edges of a finite network and allow for feedback effects between different, possibly non-adjacent edges. This generalizes the setting that is common in the literature, where the only considered interactions take place at the boundary, i. e., in the nodes of the network. We discuss well-posedness of the associated initial value problem as well as contractivity and positivity properties of its solutions. Finally, we discuss qualitative properties that can be formulated in terms of invariance of linear subspaces of the state space, i. e., of symmetries of the associated physical system. Applications to a neurobiological model as well as to a system of linear Schroedinger equations on a quantum graph are discussed.Comment: 25 pages. Corrected typos and minor change

Structural compliance effects on the accuracy and safety of a R-CUBE haptic device

28th International Conference on Robotics in Alpe-Adria-Danube Region, RAAD 2019; Kaiserslautern; Germany; 19 June 2019 through 21 June 2019This paper addresses the contribution of structural compliance on stiffness and safety of a R-CUBE Haptic Device. Structural compliance is determined in several poses via FEM analysis and addressed by referring to local and global indices of performance. Results are also compared with evidences from experimental tests. Comparison of numerical and experimental data allows to identify and separate the contributions to the overall compliance that are due to the structural stiffness, and other contributions such as joint clearance, pose and loading conditions.Axis IT and T (20/01.09.2016), European Regional Development Fun

Entropy Corrections for Schwarzschild and Reissner-Nordstr\"om Black Holes

Schwarzschild black hole being thermodynamically unstable, corrections to its entropy due to small thermal fluctuations cannot be computed. However, a thermodynamically stable Schwarzschild solution can be obtained within a cavity of any finite radius by immersing it in an isothermal bath. For these boundary conditions, classically there are either two black hole solutions or no solution. In the former case, the larger mass solution has a positive specific heat and hence is locally thermodynamically stable. We find that the entropy of this black hole, including first order fluctuation corrections is given by: {\cal S} = S_{BH} - \ln[\f{3}{R} (S_{BH}/4\p)^{1/2} -2]^{-1} + (1/2) \ln(4\p), where $S_{BH}=A/4$ is its Bekenstein-Hawking entropy and $R$ is the radius of the cavity. We extend our results to four dimensional Reissner-Nordstr\"om black holes, for which the corresponding expression is: {\cal S} = S_{BH} - \f{1}{2} \ln [ {(S_{BH}/\p R^2) ({3S_{BH}}/{\p R^2} - 2\sqrt{{S_{BH}}/{\p R^2 -\a^2}}) \le(\sqrt{{S_{BH}}/{\p R^2}} - \a^2 \ri)}/ {\le({S_{BH}}/{\p R^2} -\a^2 \ri)^2} ]^{-1} +(1/2)\ln(4\p). Finally, we generalise the stability analysis to Reissner-Nordstr\"om black holes in arbitrary spacetime dimensions, and compute their leading order entropy corrections. In contrast to previously studied examples, we find that the entropy corrections in these cases have a different character.Comment: 6 pages, Revtex. References added, minor changes. Version to appear in Class. Quant. Gra

Modes of Oscillation in Radiofrequency Paul Traps

We examine the time-dependent dynamics of ion crystals in radiofrequency traps. The problem of stable trapping of general three-dimensional crystals is considered and the validity of the pseudopotential approximation is discussed. We derive analytically the micromotion amplitude of the ions, rigorously proving well-known experimental observations. We use a method of infinite determinants to find the modes which diagonalize the linearized time-dependent dynamical problem. This allows obtaining explicitly the ('Floquet-Lyapunov') transformation to coordinates of decoupled linear oscillators. We demonstrate the utility of the method by analyzing the modes of a small `peculiar' crystal in a linear Paul trap. The calculations can be readily generalized to multispecies ion crystals in general multipole traps, and time-dependent quantum wavefunctions of ion oscillations in such traps can be obtained.Comment: 24 pages, 3 figures, v2 adds citations and small correction