Influence of building geometry on bending and shear deformations of buildings subject to tunnelling subsidence:numerical modelling

Masonry buildings in urban areas can be damaged by differential ground movements caused by underground excavations. Existing procedures for the assessment of building damage due to excavation-induced settlements include the effect of the building on the settlement trough in terms of building stiffness relative to soil stiffness. In these procedures, the relative stiffness is calculated by considering either the bending stiffness or the shear stiffness of the building. In this paper, finite element modelling of buildings subjected to tunneling-induced settlements is used to determine the relative importance of shear and bending deformations in damage predictions. Computational modelling was first validated by simulating centrifuge tests on 3D printed small scale models of masonry buildings subjected to tunneling in sand. Using a similar modelling approach, a sensitivity study was then conducted on the governing effect of shear or bending deformations for different amounts of facade openings. Results indicate the need to include both shear and bending deformation in assessment procedures, and provide essential data towards this objective

Influence of building geometry on bending and shear deformations of buildings subject to tunnelling subsidence:centrifuge testing

Tunnelling-induced settlement damage to pre-existing buildings is a result of bending and shear deformations, which typically occur simultaneously. However, widely accepted methods to assess building damage caused by tunnelling subsidence focus only on the mode of deformation (i.e. shear or bending) that is assumed to govern the onset of building damage. Furthermore, building damage assessment methods typically relate the dominant mode of deformation to the length to height ratio, L/H, of the structure, while more recent research reported that facade openings significantly affect the dominant deformation mode. This paper presents a series of centrifuge tests that explore bending and shear effects on surface structures that are affected by a shallow tunnel excavation in sand. The tests were performed on3D printed building models with varying L/H ratio and facade openings. The response of these building models to the ground movements caused by the tunnelling operation is monitored using digital image correlation (DIC). Results show that bending deformations increase with the L/H ratio while shearing becomes dominant as the amount of facade openings increases. It is also shown that shearing and bending occur simultaneously and therefore should be combined in future damage assessment methods. The obtained experimental results provide essential benchmark data for computational modelling of tunnelling-induced settlement damage on surface structures, as presented in the companion paper

A comparison of current analytical methods for predicting soil-structure interaction due to tunnelling

Current procedures for the assessment of buildings response to tunnelling take into account the effect of soil-structure interaction through the definition of the building stiffness relative to the soil stiffness. Limitations of these procedures are uncertainties in the evaluation of structural parameters and inconsistent results between different methods. In this paper, three existing formulations of the Relative Stiffness Method (RSM) have been critically evaluated by analysing the governing factors in the building stiffness calculation and their effect on the structural damage assessment. The results of a sensitivity study on building height, eccentricity, opening ratio, tunnel depth, soil and masonry stiffness, and trough width parameter quantified the effect of these factors on the considered RSMs. The application of different RSMs to a real masonry building adjacent to the Jubilee Line tunnel excavation underlined the significant effect of window openings, façade stiffness and neutral axis position on the building stiffness calculation and deformation prediction. These results highlight the need for a consistent and robust damage assessment procedure.</p

Mediodorsal Thalamic Neurons Mirror the Activity of Medial Prefrontal Neurons Responding to Movement and Reinforcement during a Dynamic DNMTP Task

The mediodorsal nucleus (MD) interacts with medial prefrontal cortex (mPFC) to support learning and adaptive decision-making. MD receives driver (layer 5) and modulatory (layer 6) projections from PFC and is the main source of driver thalamic projections to middle cortical layers of PFC. Little is known about the activity of MD neurons and their influence on PFC during decision-making. We recorded MD neurons in rats performing a dynamic delayed nonmatching to position (dDNMTP) task and compared results to a previous study of mPFC with the same task (Onos et al., 2016). Criterion event-related responses were observed for 22% (254/1179) of neurons recorded in MD, 237 (93%) of which exhibited activity consistent with mPFC response types. More MD than mPFC neurons exhibited responses related to movement (45% vs. 29%) and reinforcement (51% vs. 27%). MD had few responses related to lever presses, and none related to preparation or memory delay, which constituted 43% of event-related activity in mPFC. Comparison of averaged normalized population activity and population response times confirmed the broad similarity of common response types in MD and mPFC and revealed differences in the onset and offset of some response types. Our results show that MD represents information about actions and outcomes essential for decision-making during dDNMTP, consistent with evidence from lesion studies that MD supports reward-based learning and action-selection. These findings support the hypothesis that MD reinforces task-relevant neural activity in PFC that gives rise to adaptive behavior

SN 2006bp: Probing the Shock Breakout of a Type II-P Supernova

HET optical spectroscopy and unfiltered ROTSE-III photometry spanning the first 11 months since explosion of the Type II-P SN 2006bp are presented. Flux limits from the days before discovery combined with the initial rapid brightening suggest the supernova was first detected just hours after shock breakout. Optical spectra obtained about 2 days after breakout exhibit narrow emission lines corresponding to HeII 4200, HeII 4686, and CIV 5805 in the rest frame, and these features persist in a second observation obtained 5 hours later; however, these emission lines are not detected the following night nor in subsequent observations. We suggest that these lines emanate from material close to the explosion site, possibly in the outer layers of the progenitor that have been ionized by the high energy photons released at shock breakout. A P-Cygni profile is observed around 4450 A in the +2 and +3 day spectra. Previous studies have attributed this feature to high velocity H-beta, but we discuss the possibility that this profile is instead due to HeII 4687. Further HET observations (14 nights in total) covering the spectral evolution across the photometric plateau up to 73 days after breakout and during the nebular phase around day +340 are presented, and expansion velocities are derived for key features. The measured decay slope for the unfiltered light curve is 0.0073 +/- 0.0004 mag/day between days +121 and +335, which is significantly slower than the decay of rate 56Co. We combine our HET measurements with published X-ray, UV, and optical data to obtain a quasi-bolometric light curve through day +60. We see a slow cooling over the first 25 days, but no sign of an early sharp peak; any such feature from the shock breakout must have lasted less than ~1 day.[ABRIDGED]Comment: ApJ accepted, 43 page

Prefrontal Neurons Encode Actions and Outcomes in Conjunction with Spatial Location in Rats Performing a Dynamic Delayed Non-Match to Position Task

To respond adaptively to change organisms must utilize information about recent events and environmental context to select actions that are likely to produce favorable outcomes. We developed a dynamic delayed nonmatching to position task to study the influence of spatial context on event-related activity of medial prefrontal cortex neurons during reinforcement-guided decision-making. We found neurons with responses related to preparation, movement, lever press responses, reinforcement, and memory delays. Combined event-related and video tracking analyses revealed variability in spatial tuning of neurons with similar event-related activity. While all correlated neurons exhibited spatial tuning broadly consistent with relevant task events, for instance reinforcement-related activity concentrated in locations where reinforcement was delivered, some had elevated activity in more specific locations, for instance reinforcement-related activity in one of several locations where reinforcement was delivered. Timing analyses revealed a limited set of distinct response types with activity time-locked to critical behavioral events that represent the temporal organization of dDNMTP trials. Our results suggest that reinforcement-guided decision-making emerges from discrete populations of medial prefrontal neurons that encode information related to planned or ongoing movements and actions and anticipated or actual action-outcomes in conjunction with information about spatial context

Integrated transcriptomic and proteomic analyses ofP. falciparumgametocytes: molecular insight into sex-specific processes and translational repression

Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here, we report the first transcriptome analysis of male and female Plasmodium falciparum gametocytes coupled with a comprehensive proteome analysis. In male gametocytes there is an enrichment of proteins involved in the formation of flagellated gametes; proteins involved in DNA replication, chromatin organization and axoneme formation. On the other hand, female gametocytes are enriched in proteins required for zygote formation and functions after fertilization; protein-, lipid- and energy-metabolism. Integration of transcriptome and proteome data revealed 512 highly expressed maternal transcripts without corresponding protein expression indicating large scale translational repression in P. falciparum female gametocytes for the first time. Despite a high degree of conservation between Plasmodium species, 260 of these 'repressed transcripts' have not been previously described. Moreover, for some of these genes, protein expression is only reported in oocysts and sporozoites indicating that repressed transcripts can be partitioned into short- and long-term storage. Finally, these data sets provide an essential resource for identification of vaccine/drug targets and for further mechanistic studies