90 research outputs found
Voices of the Undereducated in Adult Education and Training in Ontario: A Phenomenographic Approach
This doctoral study was an exploration of the qualitatively different ways in which undereducated adults (at or below a high school level of formal education) reported their experiences of participation in adult education and training (AET) programmes offered by publicly funded school boards or their arms-length affiliate in the province of Ontario. In light of a low participation rate in the Canadian AET system by undereducated adults, the rationale was to examine whether or not AET programmes are meeting the needs of undereducated adults beyond a narrow focus on an instrumental approach associated with human capital development. This study was located in a theoretical framework consisting of (a) learning theory, (b) motivations for participation, (c) general barriers to participation, (d) structural barriers to participation, and (e) transformative learning. The purposive sample consisted of 11 participants between the ages of 18-58 who were drawn from service providers in 4 geographic regions of Ontario. Data collection consisted of (a) demographics, (b) voice recordings from face-to-face participant interviews, (c) participant weekly critical incident reports, and (d) researcher reflexive journal notes. Data were analyzed in accordance with a phenomenographic approach within a constructivist/interpretivist research paradigm. Findings revealed 4 qualitatively different ways in which undereducated adult learners reported their experiences of participation in AET and were reported as the voice of (a) security, (b) engagement, (c) relationship, and (d) competency. Implications to theory and practice and to further inquiry were outlined
CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
<p>Abstract</p> <p>Background</p> <p>Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.</p> <p>Methods</p> <p>We screened for TICs in 47 human adult brain malignant tumors. Cells forming floating spheres in culture, and endowed with all of the features expected from tumor cells with stem-like properties were obtained from glioblastomas, medulloblastoma but not oligodendrogliomas.</p> <p>Results</p> <p>A long-term self-renewal capacity was particularly observed for cells of malignant glio-neuronal tumors (MGNTs). Cell sorting, karyotyping and proteomic analysis demonstrated cell stability throughout prolonged passages. Xenografts of fewer than 500 cells in Nude mouse brains induced a progressively growing tumor. CD133, CD15/LeX/Ssea-1, CD34 expressions, or exclusion of Hoechst dye occurred in subsets of cells forming spheres, but was not predictive of their capacity to form secondary spheres or tumors, or to resist high doses of temozolomide.</p> <p>Conclusions</p> <p>Our results further highlight the specificity of a subset of high-grade gliomas, MGNT. TICs derived from these tumors represent a new tool to screen for innovative therapies.</p
Synthèse de la calothrixine et d'un analogue
Communication par affiche intitulée (présentée par L. Maingot) : Synthèse de la calothrixine et d'un analogu
Elliptic problems with robin boundary coefficient-operator conditions in general L<sup>p</sup> sobolev spaces and applications
In this paper we prove some new results on complete operational second order differential equations of elliptic type with coeficient-operator conditions, in the framework of the space Lp(0; 1;X) with general p 08 (1;+ 1e), X being a UMD Banach space. Existence, uniqueness and optimal regularity of the classical solution are proved. This paper improves and completes naturally our last two works on this problematic
Boundary value problem for elliptic differential equations in non-commutative cases
We consider a boundary value problem for elliptic differential equations in non-commutative case
Complete abstract differential equations of elliptic type with general Robin boundary conditions, in UMD spaces
In this paper we prove some new results concerning a complete abstract second-order differential equation with general Robin boundary conditions. The study is developped in UMD spaces and uses the celebrated Dore-Venni Theorem. We prove existence, uniqueness and maximal regularity of the strict solution. This work completes previous one [3] by authors; see also [11]
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