The genetic basis of host preference and resting behavior in the major African malaria vector, Anopheles arabiensis

Malaria transmission is dependent on the propensity of Anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. Recent increases in the usage of Long Lasting Insecticide Treated Nets (LLINs) in Africa have been associated with reductions in highly anthropophilic and endophilic vectors such as Anopheles gambiae s.s., leaving species with a broader host range, such as Anopheles arabiensis, as the most prominent remaining source of transmission in many settings. An. arabiensis appears to be more of a generalist in terms of its host choice and resting behavior, which may be due to phenotypic plasticity and/or segregating allelic variation. To investigate the genetic basis of host choice and resting behavior in An. arabiensis we sequenced the genomes of 23 human-fed and 25 cattle-fed mosquitoes collected both in-doors and out-doors in the Kilombero Valley, Tanzania. We identified a total of 4,820,851 SNPs, which were used to conduct the first genome-wide estimates of “SNP heritability”for host choice and resting behavior in this species. A genetic component was detected for host choice (human vs cow fed; permuted P = 0.002), but there was no evidence of a genetic component for resting behavior (indoors versus outside; permuted P = 0.465). A principal component analysis (PCA) segregated individuals based on genomic variation into three groups which were characterized by differences at the 2Rb and/or 3Ra paracentromeric chromosome inversions. There was a non-random distribution of cattle-fed mosquitoes between the PCA clusters, suggesting that alleles linked to the 2Rb and/or 3Ra inversions may influence host choice. Using a novel inversion genotyping assay, we detected a significant enrichment of the standard arrangement (non-inverted) of 3Ra among cattle-fed mosquitoes (N = 129) versus all non-cattle-fed individuals. Thus, tracking the frequency of the 3Ra in An. arabiensis populations may be of use to infer selection on host choice behavior within these vector populations; possibly in response to vector control. Controlled host-choice assays are needed to discern whether the observed genetic component has a direct relationship with innate host preference. A better understanding of the genetic basis for host feeding behavior in An. arabiensis may also open avenues for novel vector control strategies based on driving genes for zoophily into wild mosquito populations

Photodissociation in Quantum Chaotic Systems: Random Matrix Theory of Cross-Section Fluctuations

Using the random matrix description of open quantum chaotic systems we calculate in closed form the universal autocorrelation function and the probability distribution of the total photodissociation cross section in the regime of quantum chaos.Comment: 4 pages+1 eps figur

Power Laws, Precursors and Predictability During Failure

We investigate the dynamics of a modified Burridge-Knopoff model by introducing a dissipative term to mimic the bursts of acoustic emission (AE) from rock samples. The model explains many features of the statistics of AE signals observed in experiments such as the crossover in the exponent value from relatively small amplitude AE signals to larger regime, and their dependence on the pulling speed. Significantly, we find that the cumulative energy dissipated identified with acoustic emission can be used to predict a major slip event. We also find a data collapse of the acoustic activity for several major slip events describable by a universal stretched exponential with corrections in terms of time-to-failure.Comment: 7 pages, 6 figures, Final version with minor change

Imaging Inter-Edge State Scattering Centers in the Quantum Hall Regime

We use an atomic force microscope tip as a local gate to study the scattering between edge channels in a 2D electron gas in the quantum Hall regime. The scattering is dominated by individual, microscopic scattering centers, which we directly image here for the first time. The tip voltage dependence of the scattering indicates that tunneling occurs through weak links and localized states.Comment: 4 pages, 5 figure

Scintillation of PSR B1508+55 -- the view from a 10,000-km baseline

We report on the simultaneous Giant Metrewave Radio Telescope (GMRT) and Algonquin Radio Observatory (ARO) observations at 550-750 MHz of the scintillation of PSR B1508+55, resulting in a $\sim$10,000-km baseline. This regime of measurement lies between the shorter few 100-1000~km baselines of earlier multi-station observations and the much longer earth-space baselines. We measure a scintillation cross-correlation coefficient of $0.22$, offset from zero time lag due to a $\sim 45$~s traversal time of the scintillation pattern. The scintillation time of 135~s is $3\times$ longer, ruling out isotropic as well as strictly 1D scattering. Hence, the low cross-correlation coefficient is indicative of highly anisotropic but 2D scattering. The common scintillation detected on the baseline is confined to low delays of $\lesssim 1 \mu$s, suggesting that this correlation may not be associated with the parabolic scintillation arc detected at the GMRT. Detection of pulsed echoes and their direct imaging with the Low Frequency Array (LOFAR) by a different group enable them to measure a distance of 125~pc to the screen causing these echoes. These previous measurements, alongside our observations, lead us to propose that there are at least two scattering screens: the closer 125 pc screen causing the scintillation arc detected at GMRT, and a screen further beyond causing the scintillation detected on the GMRT-ARO baseline. We advance the hypothesis that the 125-pc screen partially resolves the speckle images on the screen beyond leading to loss of coherence in the scintillation dynamic spectrum, to explain the low cross-correlation coefficient.Comment: 10 pages, 8 figures, accepted for publication in MNRA

Quantum Hall fluctuations and evidence for charging in the quantum Hall effect

We find that mesoscopic conductance fluctuations in the quantum Hall regime in silicon MOSFETs display simple and striking patterns. The fluctuations fall into distinct groups which move along lines parallel to loci of integer filling factor in the gate voltage-magnetic field plane. Also, a relationship appears between the fluctuations on quantum Hall transitions and those found at low densities in zero magnetic field. These phenomena are most naturally attributed to charging effects. We argue that they are the first unambiguous manifestation of interactions in dc transport in the integer quantum Hall effect.Comment: 4 pages RevTeX including 4 postscript bitmapped figure