Low-grade B-cell lymphoma presenting primarily in the bone marrow

Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma

Comparison of Mechanical Properties of PMMA Disks for Digitally Designed Dentures

In this study, the physical properties of a custom block manufactured using a self-polymerizing resin (Custom-block), the commercially available CAD/CAM PMMA disk (PMMA-disk), and a heat-polymerizing resin (Conventional PMMA) were evaluated via three different tests. The Custom-block was polymerized by pouring the self-polymerizing resin into a special tray, and Conventional PMMA was polymerized with a heat-curing method, according to the manufacturer’s recommended procedure. The specimens of each group were subjected to three-point bending, water sorption and solubility, and staining tests. The results showed that the materials met the requirements of the ISO standards in all tests, except for the staining tests. The highest flexural strength was exhibited by the PMMA-disk, followed by the Custom-block and the Conventional PMMA, and a significant difference was observed in the flexural strengths of all the materials (p < 0.001). The Custom-block showed a significantly higher flexural modulus and water solubility. The water sorption and discoloration of the Custom-block were significantly higher than those of the PMMA-disk, but not significantly different from those of the Conventional PMMA. In conclusion, the mechanical properties of the three materials differed depending on the manufacturing method, which considerably affected their flexural strength, flexural modulus, water sorption and solubility, and discoloration

Patient preferences for different tooth replacement strategies for the edentulous mandible: A Willingness-To-Pay analysis

10.2186/jpr.JPR_D_20_00170Journal of Prosthodontic Researc

Effect of digital complete dentures manufactured using the custom disk method on masticatory function

Statement of problem: The effect of using the custom disk method (CDM) for fabricating digital dentures on patients’ masticatory function should be studied to support its use in clinical practice. Purpose: To investigate the effect of digital dentures fabricated using CDM on patients’ masticatory function. Material and methods: This single-center prospective clinical study included 20 patients with edentulous maxillary and mandibular arches who used a complete denture. The digital impression and complete denture manufacturing procedures using CDM have already been reported by Kanazawa et al. (2018) [32] and Soeda et al. (2022) [18] Thedigital dentures fabricated with CDM were delivered to the participants, and periodic adjustments were made until the patient could use the denture without pain. A color-changeable chewing gum, two types of gummy jellies that can evaluate the masticatory function, and pressure-sensitive sheets were used to evaluate the participants’ masticatory function at baseline, 1 month, and 6 months following adjustment of the new digital complete dentures fabricated with CDM. These masticatory function values had already been measured in the previous conventional dentures and were recorded as baseline values. Results: The study participants included 8 women and 12 men (mean age, 77.6 years). The color-changeable chewing gum analysis indicated that there was no significant improvement of masticatory function from baseline to 1 M (P = .083) and 6 M (P = .157).The gummy jelly analysis indicated no significant differences between the masticatory function baseline and 1 month (P = .387); however, a significant improvement was observed from baseline to 6 months (P = .020). Tests with Glucolum indicated a significant improvement from baseline to 1 month (P = .012) and 6 months (P = .003). The maximum bite force and occlusal contact area showed no significant difference at any time point. Conclusions: Significant improvement in masticatory function was observed upon evaluation with gummy jelly and Glucolum 6 months after delivering the new digital complete dentures. Under limited conditions, the digital denture fabricated using CDM resulted in good recovery of the masticatory function in elderly edentulous patients. The present results combined with the cost-effectiveness and patient satisfaction associated with CDM indicate its clinical utility

Effect of Different Filler Contents and Printing Directions on the Mechanical Properties for Photopolymer Resins

Photopolymer resins are widely used in the production of dental prostheses, but their mechanical properties require improvement. We evaluated the effects of different zirconia filler contents and printing directions on the mechanical properties of photopolymer resin. Three-dimensional (3D) printing was used to fabricate specimens using composite photopolymers with 0 (control), 3, 5, and 10 wt.% zirconia filler. Two printing directions for fabricating rectangular specimens (25 mm × 2 mm × 2 mm) and disk-shaped specimens (φ10 mm × 2 mm) were used, 0° and 90°. Three-point bending tests were performed to determine the flexural strengths and moduli of the specimens. The Vickers hardness test was performed to determine the hardness of the specimens. Tukey’s multiple comparison tests were performed on the average values of the flexural strengths, elastic moduli, and Vickers hardness after one-way ANOVA (α = 0.05). The flexural strengths and elastic moduli at 0° from high to low were in the order of 0, 3, 10, and 5 wt.%, and those at 90° were in the order of 3, 0, 10, and 5 wt.% (p < 0.05). For 5 and 10 wt.%, no significant differences were observed in mechanical properties at 0° and 90° (p < 0.05). The Vickers hardness values at 0° and 90° from low to high were in the order of 0, 3, 5, and 10 wt.% (p < 0.05). Within the limits of this study, the optimal zirconia filler content in the photopolymer resin for 3D printing was 0 wt.% at 0° and 3 wt.% at 90°

Patient preferences for different tooth replacement strategies for the edentulous mandible: A Willingness-To-Pay analysis

Purpose The aim of this study was to evaluate patients' economic preferences for two different tooth replacement strategies for the edentulous mandible namely conventional complete dentures (CCDs) and implant overdentures supported by two implants (IODs), using a willingness-to-pay (WTP) analysis. Methods Twenty-six elderly patients who had been rehabilitated with either a mandibular CCD or IOD were invited to participate in this study. All participants were provided with the details of the two treatment protocols, including advantages, disadvantages, and treatment costs. The patients were then asked to indicate their maximum WTP values for each protocol using a payment card method for contingency evaluation. Results Fifteen patients with mandibular CCD (CCD-Group) and 12 patients with IOD (IOD-Group) participated in the study. Overall, the median and maximum WTP values recorded for IOD therapy were significantly higher than those for CCD therapy (p<0.05). Both treatment groups recorded maximum WTP values for CCD therapy, which exceeded the market cost (¥30,000 [US$280]), CCD-Group: ¥50,000 (interquartile range [IQR]: 40,000 – 65,000), and IOD-Group: ¥45,000 (IQR: 30,000–85,000)]. However, both groups registered a median and maximum WTP values for IOD therapy lower than the market cost (¥780,000 [US$7,300]), (CCD-Group: ¥500,000 [IQR: 300,000 - 750,000], IOD-Group: ¥700,000 [IQR: 500,000–800,000]). Conclusion The maximum WTP values recorded for IOD therapy were significantly higher than CCD therapy in both treatment groups. While patients were willing to pay more than the current market costs for CCDs, they were not willing to meet the market value for IODs