361 research outputs found
Understanding High-Temperature Superconductors with Quantum Cluster Theories
Quantum cluster theories are a set of approaches for the theory of correlated
and disordered lattice systems, which treat correlations within the cluster
explicitly, and correlations at longer length scales either perturbatively or
within a mean-field approximation. These methods become exact when the cluster
size diverges, and most recover the corresponding (dynamical) mean-field
approximation when the cluster size becomes one. Here we will review systematic
dynamical cluster simulations of the two-dimensional Hubbard model, that
display phenomena remarkably similar to those found in the cuprates, including
antiferromagnetism, superconductivity and pseudogap behavior. We will then
discuss results for the structure of the pairing mechanism in this model,
obtained from a combination of dynamical cluster results and diagrammatic
techniques.Comment: 8 pages, 12 figures; submitted to proceedings of M2S-HTSC VIII,
Dresden 200
The 3-Band Hubbard-Model versus the 1-Band Model for the high-Tc Cuprates: Pairing Dynamics, Superconductivity and the Ground-State Phase Diagram
One central challenge in high- superconductivity (SC) is to derive a
detailed understanding for the specific role of the - and
- orbital degrees of freedom. In most theoretical studies an
effective one-band Hubbard (1BH) or t-J model has been used. Here, the physics
is that of doping into a Mott-insulator, whereas the actual high- cuprates
are doped charge-transfer insulators. To shed light on the related question,
where the material-dependent physics enters, we compare the competing magnetic
and superconducting phases in the ground state, the single- and two-particle
excitations and, in particular, the pairing interaction and its dynamics in the
three-band Hubbard (3BH) and 1BH-models. Using a cluster embedding scheme, i.e.
the variational cluster approach (VCA), we find which frequencies are relevant
for pairing in the two models as a function of interaction strength and doping:
in the 3BH-models the interaction in the low- to optimal-doping regime is
dominated by retarded pairing due to low-energy spin fluctuations with
surprisingly little influence of inter-band (p-d charge) fluctuations. On the
other hand, in the 1BH-model, in addition a part comes from "high-energy"
excited states (Hubbard band), which may be identified with a non-retarded
contribution. We find these differences between a charge-transfer and a Mott
insulator to be renormalized away for the ground-state phase diagram of the
3BH- and 1BH-models, which are in close overall agreement, i.e. are
"universal". On the other hand, we expect the differences - and thus, the
material dependence to show up in the "non-universal" finite-T phase diagram
(-values).Comment: 17 pages, 9 figure
Cluster Dynamical Mean Field Theories
Cluster Dynamical Mean Field Theories are analyzed in terms of their
semiclassical limit and their causality properties, and a translation invariant
formulation of the cellular dynamical mean field theory, PCDMFT, is presented.
The semiclassical limit of the cluster methods is analyzed by applying them to
the Falikov-Kimball model in the limit of infinite Hubbard interaction U where
they map to different classical cluster schemes for the Ising model.
Furthermore the Cutkosky-t'Hooft-Veltman cutting equations are generalized and
derived for non translation invariant systems using the Schwinger-Keldysh
formalism. This provides a general setting to discuss causality properties of
cluster methods. To illustrate the method, we prove that PCDMFT is causal while
the nested cluster schemes (NCS) in general and the pair scheme in particular
are not. Constraints on further extension of these schemes are discussed.Comment: 26 page
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification
SummaryObjective/MethodAggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhibition and modulation of disease-related endpoints with the intent of selecting a candidate for clinical development in osteoarthritis (OA).ResultsStructural mapping predicts the most potent mAbs employ a unique mode of inhibition by cross-linking the catalytic and disintegrin domains. In a surgical mouse model of OA, both ADAMTS-5 and ADAMTS-4-specific mAbs penetrate cartilage following systemic administration, demonstrating access to the anticipated site of action. Structural disease modification and associated alleviation of pain-related behavior were observed with ADAMTS-5 mAb treatment. Treatment of human OA cartilage demonstrated a preferential role for ADAMTS-5 inhibition over ADAMTS-4, as measured by ARGS neoepitope release in explant cultures. ADAMTS-5 mAb activity was most evident in a subset of patient-derived tissues and suppression of ARGS neoepitope release was sustained for weeks after a single treatment in human explants and in cynomolgus monkeys, consistent with high affinity target engagement and slow ADAMTS-5 turnover.ConclusionThis data supports a hypothesis set forth from knockout mouse studies that ADAMTS-5 is the major aggrecanase involved in cartilage degradation and provides a link between a biological pathway and pharmacology which translates to human tissues, non-human primate models and points to a target OA patient population. Therefore, a humanized ADAMTS-5-selective monoclonal antibody (GSK2394002) was progressed as a potential OA disease modifying therapeutic
Electromotive forces and the Meissner effect puzzle
In a voltaic cell, positive (negative) ions flow from the low (high)
potential electrode to the high (low) potential electrode, driven by an
`electromotive force' which points in opposite direction and overcomes the
electric force. Similarly in a superconductor charge flows in direction
opposite to that dictated by the Faraday electric field as the magnetic field
is expelled in the Meissner effect. The puzzle is the same in both cases: what
drives electric charges against electromagnetic forces? I propose that the
answer is also the same in both cases: kinetic energy lowering, or `quantum
pressure'
Neel Order and Electron Spectral Functions in the Two-Dimensional Hubbard Model: a Spin-Charge Rotating Frame Approach
Using recently developed quantum SU(2)xU(1) rotor approach, that provides a
self-consistent treatment of the antiferromagnetic state we have performed
electronic spectral function calculations for the Hubbard model on the square
lattice. The collective variables for charge and spin are isolated in the form
of the space-time fluctuating U(1) phase field and rotating spin quantization
axis governed by the SU(2) symmetry, respectively. As a result interacting
electrons appear as composite objects consisting of bare fermions with attached
U(1) and SU(2) gauge fields. This allows us to write the fermion Green's
function in the space-time domain as the product CP^1 propagator resulting from
the SU(2) gauge fields, U(1) phase propagator and the pseudo-fermion
correlation function. As a result the problem of calculating the spectral line
shapes now becomes one of performing the convolution of spin, charge and
pseudo-fermion Green's functions. The collective spin and charge fluctuations
are governed by the effective actions that are derived from the Hubbard model
for any value of the Coulomb interaction. The emergence of a sharp peak in the
electron spectral function in the antiferromagnetic state indicates the decay
of the electron into separate spin and charge carrying particle excitations.Comment: 16 pages, 5 figures, submitted to Phys. Rev.
Probing the superconducting pairing symmetry from spin excitations in BiS based superconductors
Starting from a two-orbital model and based on the random phase
approximation, spin excitations in the superconducting state of the newly
discovered BiS superconductors with three possible pairing symmetries are
studied theoretically. We show that spin response is uniquely determined by the
pairing symmetry. Possible spin resonance excitations might occur for the
d-wave symmetry at an incommensurate momentum about . For the
p-wave symmetry the transverse spin excitation near is enhanced. For
the s-wave pairing symmetry there is no spin resonance signature. These
distinct features may be used for probing or determining the pairing symmetry
in this newly discovered compound.Comment: 4 pages, 5 figure
A minimum single-band model for low-energy excitations in superconducting KFeSe
We propose a minimum single-band model for the newly discovered iron-based
superconducting KFeSe. Our model is found to be numerically
consistent with the five-orbital model at low energies. Based on our model and
the random phase approximation, we study the spin fluctuation and the pairing
symmetry of superconducting gap function. The spin excitation
and the pairing symmetry are revealed. All of the results can
well be understood in terms of the interplay between the Fermi surface topology
and the local spin interaction, providing a sound picture to explain why the
superconducting transition temperature is as high as to be comparable to those
in pnictides and some cuprates. A common origin of superconductivity is
elucidated for this compound and other high-T materials.Comment: 5 pages, 4 figure
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Interspecific variation, habitat complexity and ovipositional responses modulate the efficacy of cyclopoid copepods in disease vector control
The use of predatory biological control agents can form an effective component in the management of vectors of parasitic diseases and arboviruses. However, we require predictive methods to assess the efficacies of potential biocontrol agents under relevant environmental contexts. Here, we applied functional responses (FRs) and reproductive effort as a proxy of numerical responses (NRs) to compare the Relative Control Potential (RCP) of three cyclopoid copepods, Macrocyclops albidus, M. fuscus and Megacyclops viridis towards larvae of the mosquito Culex quinquefasciatus. The effects of habitat complexity on such predatory impacts were examined, as well as ovipositional responses of C. quinquefasciatus to copepod cues in pairwise choice tests. All three copepod species demonstrated a population destabilising Type II FR. M. albidus demonstrated the shortest handling time and highest maximum feeding rate, whilst M. fuscus exhibited the highest attack rate. The integration of reproductive effort estimations in the new RCP metric identifies M. albidus as a very promising biocontrol agent. Habitat complexity did not impact the FR form or maximum feeding rate of M. albidus, indicating that potentially population destabilising effects are robust to habitat variations; however, attack rates of M. albidus were reduced in the presence of such complexity. C. quinquefasciatus avoided ovipositing where M. albidus was physically present, however it did not avoid chemical cues alone. C. quinquefasciatus continued to avoid M. albidus during oviposition when both the treatment and control water were dyed; however, when an undyed, predator-free control was paired with dyed, predator-treated water, positive selectivity towards the treatment water was stimulated. We thus demonstrate the marked predatory potential of cyclopoid copepods, utilising our new RCP metric, and advocate their feasibility in biological control programmes targeting container-style habitats. We also show that behavioural responses of target organisms and environmental context should be considered to maximise agent efficacy
Magnetic Field Amplification in Galaxy Clusters and its Simulation
We review the present theoretical and numerical understanding of magnetic
field amplification in cosmic large-scale structure, on length scales of galaxy
clusters and beyond. Structure formation drives compression and turbulence,
which amplify tiny magnetic seed fields to the microGauss values that are
observed in the intracluster medium. This process is intimately connected to
the properties of turbulence and the microphysics of the intra-cluster medium.
Additional roles are played by merger induced shocks that sweep through the
intra-cluster medium and motions induced by sloshing cool cores. The accurate
simulation of magnetic field amplification in clusters still poses a serious
challenge for simulations of cosmological structure formation. We review the
current literature on cosmological simulations that include magnetic fields and
outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure
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