Material Properties Measurements for Selected Materials

Hugoniot equation of state measurements were made on Coconino sandstone, Vacaville basalt, Kaibab limestone, Mono Crater, pumice and Zelux (a polycarbonate resin) for pressures to 2 Mb. A single data point was obtained for fused quartz at 1.6 Mb. In addition to the hugoniot studies, the uniaxial compressive stress behavior of Vacaville basalt and Zelux was investigated at strain rates from about 10(exp -5)/sec to 10(exp 3)/second. The data presented include the stress - strain relations as a function of strain rate for these two materials

Is Brane Inflation Eternal?

In this paper, we show that eternal inflation of the random walk type is generically absent in the brane inflationary scenario. Depending on how the brane inflationary universe originated, eternal inflation of the false vacuum type is still quite possible. Since the inflaton is the position of the D3-brane relative to the anti-D3-brane inside the compactified bulk with finite size, its value is bounded. In DBI inflation, the warped space also restricts the amplitude of the scalar fluctuation. These upper bounds impose strong constraints on the possibility of eternal inflation. We find that eternal inflation due to the random walk of the inflaton field is absent in both the KKLMMT slow roll scenario and the DBI scenario. A more careful analysis for the slow-roll case is also presented using the Langevin equation, which gives very similar results. We discuss possible ways to obtain eternal inflation of the random walk type in brane inflation. In the multi-throat brane inflationary scenario, the branes may be generated by quantum tunneling and roll out the throat. Eternal inflation of the false vacuum type inevitably happens in this scenario due to the tunneling process. Since these scenarios have different cosmological predictions, more data from the cosmic microwave background radiation will hopefully select the specific scenario our universe has gone through.Comment: 32 pages; v2: references and comments adde

Statistics of selectively neutral genetic variation

Random models of evolution are instrumental in extracting rates of microscopic evolutionary mechanisms from empirical observations on genetic variation in genome sequences. In this context it is necessary to know the statistical properties of empirical observables (such as the local homozygosity for instance). Previous work relies on numerical results or assumes Gaussian approximations for the corresponding distributions. In this paper we give an analytical derivation of the statistical properties of the local homozygosity and other empirical observables assuming selective neutrality. We find that such distributions can be very non-Gaussian.Comment: 4 pages, 4 figure

Association of a Bacteriophage with Meningococcal Disease in Young Adults

Despite being the agent of life-threatening meningitis, Neisseria meningitidis is usually carried asymptomatically in the nasopharynx of humans and only occasionally causes disease. The genetic bases for virulence have not been entirely elucidated and the search for new virulence factors in this species is hampered by the lack of an animal model representative of the human disease. As an alternative strategy we employ a molecular epidemiological approach to establish a statistical association of a candidate virulence gene with disease in the human population. We examine the distribution of a previously-identified genetic element, a temperate bacteriophage, in 1288 meningococci isolated from cases of disease and asymptomatic carriage. The phage was over-represented in disease isolates from young adults indicating that it may contribute to invasive disease in this age group. Further statistical analysis indicated that between 20% and 45% of the pathogenic potential of the five most common disease-causing meningococcal groups was linked to the presence of the phage. In the absence of an animal model of human disease, this molecular epidemiological approach permitted the estimation of the influence of the candidate virulence factor. Such an approach is particularly valuable in the investigation of exclusively human diseases

Quantitative electron phase imaging with high sensitivity and an unlimited field of view

As it passes through a sample, an electron beam scatters, producing an exit wavefront rich in information. A range of material properties, from electric and magnetic field strengths to specimen thickness, strain maps and mean inner potentials, can be extrapolated from its phase and mapped at the nanoscale. Unfortunately, the phase signal is not straightforward to obtain. It is most commonly measured using off-axis electron holography, but this is experimentally challenging, places constraints on the sample and has a limited field of view. Here we report an alternative method that avoids these limitations and is easily implemented on an unmodified transmission electron microscope (TEM) operating in the familiar selected area diffraction mode. We use ptychography, an imaging technique popular amongst the X-ray microscopy community; recent advances in reconstruction algorithms now reveal its potential as a tool for highly sensitive, quantitative electron phase imaging

Fractional Branes in Non-compact Type IIA Orientifolds

We study fractional D-branes in the Type-IIA theory on a non-compact orientifold of the orbifold C^3/Z_3 in the boundary state formalism. We find that the fractional D0-branes of the orbifold theory become unstable due to the presence of a tachyon, while there is a stable D-instanton whose tachyon gets projected out. We propose that the D-instanton is obtained after tachyon condensation. We evidence this by calculating the Whitehead group of the Abelian category of objects corresponding to the boundary states as being isomorphic to Z_2.Comment: 29 pages, Latex2e minor corrections. references updated. Version accepted in JHE

Observational Signatures and Non-Gaussianities of General Single Field Inflation

We perform a general study of primordial scalar non-Gaussianities in single field inflationary models in Einstein gravity. We consider models where the inflaton Lagrangian is an arbitrary function of the scalar field and its first derivative, and the sound speed is arbitrary. We find that under reasonable assumptions, the non-Gaussianity is completely determined by 5 parameters. In special limits of the parameter space, one finds distinctive ``shapes'' of the non-Gaussianity. In models with a small sound speed, several of these shapes would become potentially observable in the near future. Different limits of our formulae recover various previously known results.Comment: 53 pages, 5 figures; v3, minor revision, JCAP version; v4, numerical coefficients corrected in Appendix B, discussion on consistency condition revise