41 research outputs found
Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion
Background:
Branch retinal vein occlusion (BRVO) is one of the most commonly occurring retinal vascular abnormalities. The most common cause of visual loss in people with BRVO is macular oedema (MO). Grid or focal laser photocoagulation has been shown to reduce the risk of visual loss. Limitations to this treatment exist, however, and newer modalities may have equal or improved efficacy. Antiangiogenic therapy with anti‐vascular endothelial growth factor (anti‐VEGF) has recently been used successfully to treat MO resulting from a variety of causes.
Objectives:
To investigate the efficacy and gather evidence from randomised controlled trials (RCTs) on the potential harms of anti‐vascular endothelial growth factor (VEGF) agents for the treatment of macular oedema (MO) secondary to branch retinal vein occlusion (BRVO).
Search methods:
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2019, Issue 6); MEDLINE Ovid; Embase Ovid; the ISRCTN registry; ClinicalTrials.gov; and the WHO ICTRP. The date of the last search was 12 June 2019.
Selection criteria:
We included randomised controlled trials (RCTs) investigating BRVO. Eligible trials had to have at least six months' follow‐up where anti‐VEGF treatment was compared with another treatment, no treatment, or placebo. We excluded trials where combination treatments (anti‐VEGF plus other treatments) were used; and trials that investigated the dose and duration of treatment without a comparison group (other treatment/no treatment/sham).
Data collection and analysis:
Two review authors independently extracted the data using standard methodological procedures expected by Cochrane. The primary outcome was the proportion of participants with an improvement from baseline in best‐corrected visual acuity of greater than or equal to 15 letters (3 lines) on the Early Treatment in Diabetic Retinopathy Study (ETDRS) Chart at six months and 12 months of follow‐up. The secondary outcomes were the proportion of participants who lost greater than or equal to 15 ETDRS letters (3 lines) and the mean visual acuity (VA) change at six and 12 months, as well as the change in central retinal thickness (CRT) on optical coherence tomography from baseline at six and 12 months. We also collected data on adverse events and quality of life (QoL).
Main results:
We found eight RCTs of 1631 participants that met the inclusion criteria after independent and duplicate review of the search results. These studies took place in Europe, North America, Eastern Mediterranean region and East Asia. Included participants were adults aged 18 or over with VA of 20/40 or worse. Studies varied by duration of disease but permitted previously treated eyes as long as there was sufficient treatment‐free interval. All anti‐VEGF agents (bevacizumab, ranibizumab and aflibercept) and steroids (triamcinolone and dexamethasone) were included. Overall, we judged the studies to be at moderate or unclear risk of bias. Four of the eight studies did not mask participants or outcome assessors, or both.
One trial compared anti‐VEGF to sham. At six months, eyes receiving anti‐VEGF were significantly more likely to have a gain of 15 or more ETDRS letters (risk ratio (RR) 1.72, 95% confidence interval (CI) 1.19 to 2.49; 283 participants; moderate‐certainty evidence). Mean VA was better in the anti‐VEGF group at six months compared with control (mean difference (MD) 7.50 letters, 95% CI 5.29 to 9.71; 282 participants; moderate‐certainty evidence). Anti‐VEGF also proved more effective at reducing CRT at six months (MD −57.50 microns, 95% CI −108.63 to −6.37; 281 participants; lower CRT is better; moderate‐certainty evidence). There was only very low‐certainty evidence on adverse effects. There were no reports of endophthalmitis. Mean change in QoL (measured using the National Eye Institute Visual Functioning Questionnaire VFQ‐25) was better in people treated with anti‐VEGF compared with people treated with sham (MD 7.6 higher score, 95% CI 4.3 to 10.9; 281 participants; moderate‐certainty evidence).
Three RCTs compared anti‐VEGF with macular laser (total participants = 473). The proportion of eyes gaining 15 or more letters was greater in the anti‐VEGF group at six months (RR 2.09, 95% CI 1.44 to 3.05; 2 studies, 201 participants; moderate‐certainty evidence). Mean VA in the anti‐VEGF groups was better than the laser groups at six months (MD 9.63 letters, 95% CI 7.23 to 12.03; 3 studies, 473 participants; moderate‐certainty evidence). There was a greater reduction in CRT in the anti‐VEGF group compared with the laser group at six months (MD −147.47 microns, 95% CI −200.19 to −94.75; 2 studies, 201 participants; moderate‐certainty evidence). There was only very low‐certainty evidence on adverse events. There were no reports of endophthalmitis. QoL outcomes were not reported.
Four studies compared anti‐VEGF with intravitreal steroid (875 participants). The proportion of eyes gaining 15 or more ETDRS letters was greater in the anti‐VEGF group at six months (RR 1.67, 95% CI 1.33 to 2.10; 2 studies, 330 participants; high‐certainty evidence) and 12 months (RR 1.76, 95% CI 1.36 to 2.28; 1 study, 307 participants; high‐certainty evidence). Mean VA was better in the anti‐VEGF group at six months (MD 8.22 letters, 95% CI 5.69 to 10.76; 2 studies, 330 participants; high‐certainty evidence) and 12 months (MD 9.15 letters, 95% CI 6.32 to 11.97; 2 studies, 343 participants; high‐certainty evidence). Mean CRT also showed a greater reduction in the anti‐VEGF arm at 12 months compared with intravitreal steroid (MD −26.92 microns, 95% CI −65.88 to 12.04; 2 studies, 343 participants; moderate‐certainty evidence). People receiving anti‐VEGF showed a greater improvement in QoL at 12 months compared to those receiving steroid (MD 3.10, 95% CI 0.22 to 5.98; 1 study, 307 participants; moderate‐certainty evidence). Moderate‐certainty evidence suggested increased risk of cataract and raised IOP with steroids. There was only very low‐certainty evidence on APTC events. No cases of endophthalmitis were observed.
Authors' conclusions:
The available RCT evidence suggests that treatment of MO secondary to BRVO with anti‐VEGF improves visual and anatomical outcomes at six and 12 months
Re: Bhatti et al.: Microcystic macular edema in optic nerve glioma (Ophthalmology. 2020;127:930)
Awareness of olfactory impairment in a cohort of patients with CNGB1-associated retinitis pigmentosa
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Effect of varying skin surface electrode position on electroretinogram responses recorded using a handheld stimulating and recording system
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Classification and heritability of macular pigment spatial profile phenotypes using two-wavelength fundus autofluorescence
Purpose:
We investigated the frequency and heritability of macular pigment (MP) spatial profile phenotypes determined by objective and subjective profile classification based on fundus autofluorescence (FAF).
Methods:
Between scans Coefficient of Repeatability (CoR) of MP optical density (MPOD) was calculated from two FAF scans (Spectralis, Heidelberg, Germany) of 40 participants (39±8.6 years) acquired in a single session. We then analyzed two FAF scans acquired in a single session from 314 twins (157 pairs; 39±8.8 years) and classified each MP profile as exponential, ring-like or central dip by subjective visual assessment. Profiles were also classified objectively based on deviations larger than the CoR away from the exponential fit. We calculated Kappa agreement of the profiling methods, case-wise concordance of non-exponential profiles for the 88 mono- (MZ) and 69 dizygotic (DZ) twin pairs, and profile heritability.
Results:
Following visual subjective profiling, 64% showed an exponential profile, 27% presented ring-like and 9% central dip profiles; case-wise concordance was 0.80 for MZ and 0.41 for DZ twins. Following objective classification, 71% showed an exponential profile, 29% ring-like profile and no central dip profiles were identified; case-wise concordance was 0.74 for MZ and 0.36 for DZ twins. Heritability was calculated as 81.5% (95% CI 61.1 to 93.1). Between scan repeatability of profile classification showed good agreement objectively (κ=0.85, 95% CI 0.69 to 1.00; P<0.0005) and moderate agreement visually (κ=0.48, 95% CI 0.23 to 0.73; P<0.0005). Agreement of subjective versus objective profiling was low (κ=0.23, 95% CI 0.04 to 0.42; P=0.02).
Conclusions:
MP profiles showed high heritability. Compared to visual assessment, objective profile classification is a more reliable method for future experimental studies using FAF
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Electrophysiological Assessment in Birdshot Chorioretinopathy: Use of a Portable Device in the Clinic
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Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device
Purpose: The flicker electroretinogram (ERG) is a sensitive indicator of retinal dysfunction in birdshot chorioretinopathy (BCR). We explored recordings from a handheld device in BCR, comparing these with conventional recordings in the same patients and with handheld ERGs from healthy individuals.
Methods: Non-mydriatic flicker ERGs, using the handheld RETeval system (LKC Technologies), were recorded with skin electrodes at two centers. At one center (group 1), the stimuli (85 Td·s, 850 Td background) delivered retinal illuminance equivalent to international standards; at the other center (group 2), a different protocol was used (32 Td·s, no background). Patients also underwent international standard flicker ERG recordings with conventional electrodes following mydriasis. Portable ERGs from patients were also compared with those from healthy individuals.
Results: Thirty-two patients with BCR (mean age ± SD, 56.4 ± 11.3 years) underwent recordings. Portable and standard ERG parameters correlated strongly (r > 0.75, P < 0.01) in both groups. Limits of agreement for peak times were tighter in group 1 (n = 21; −4.3 to+2.0ms [right eyes], −3.9to1.5ms [left eyes]) than in group 2(n=11;−3.4 to +6.9 ms [right eyes], −4.8 to +9.0 ms [left eyes]). Compared with healthy controls (n =66 and n =90 for groups 1 and 2, respectively), patients with BCR showed smaller mean amplitudes and longer peak times.
Conclusions: Portable ERGs correlated strongly with conventional recordings, suggesting potential in rapid assessment of cone system function in office settings.
Translational Relevance: Flicker ERGs, known to be useful in BCR, can be obtained rapidly with a portable device with skin electrodes and natural pupils