Retraction Note to: The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial

This article has been retracted at the request of the IJRM editorial board, based on the results of an investigation which found serious flaws in the study results. The online version of the original article can be found at http://ijrm.ir/article-1-733-en.htm

The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study

Background Women with polycystic ovarian syndrome (PCOS) are known to have elevated circulating Anti-Müllerian hormone (AMH), which has been found to desensitize ovarian follicles to follicle stimulating hormone (FSH). The purpose of this study was to investigate the impact of high circulating AMH on ovarian responsiveness to ovulation induction with gonadotrophins in PCOS women. Methods This prospective observational pilot study was conducted in two collaborating Fertility Centres in the UK and Egypt. The study included 20 consecutive anovulatory women with PCOS who underwent 34 cycles of human menopausal gonadotrophin (hMG) ovarian stimulation using chronic low-dose step up protocol. Blood samples were collected for the measurement of serum AMH concentrations in the early follicular (day 2-3) phase in all cycles of hMG treatment. The serum levels of AMH were compared between cycles with good vs. poor response. The good response rates and the total dose and duration of hMG treatment were compared between cycles with high vs. low serum AMH concentrations. Results Cycles with poor response (no or delayed ovulation requiring >20 days of hMG treatment) had significantly (p = .007) higher median{range} serum AMH concentration (6.5{3.2-13.4}ng/ml) compared to that (4.0{2.2-10.2}ng/ml) of cycles with good response (ovulation within 20 days of hMG treatment). ROC curve showed AMH to be a useful predictor of poor response to hMG stimulation (AUC, 0.772; P = 0.007). Using a cut-off level of 4.7 ng/ml, AMH had a sensitivity of 100% and specificity of 58% in predicting poor response. The good response rate was significantly (p  = 4.7 ng/ml (100% vs. 35%, respectively). All cycles with markedly raised serum AMH levels (> 10.2 ng/ml) were associated with poor response. Cycles with high AMH (> = 4.7 ng/ml) required significantly (p < .001) greater amounts (median {range}, 1087{450-1650}IU) and longer duration (20 {12-30}days) of hMG stimulation than cycles with lower AMH (525 {225-900}IU and 8{6-14}days). Conclusions PCOS women with markedly raised circulating AMH seem to be resistant to hMG ovulation induction and may require a higher starting dose

Complications after Use of Iliac Bone Graft for Post Cleft Alveolar Bone Defect

Background: The purpose of the present study was to evaluate the efficacy of the iliac bone graft for secondary alveolar bone grafting in cleft patients and to monitor its complications as a donor site during the last five years, in maxillofacial unit, faculty of medicine, Assiut University, Egypt.Methods: Eighteen cleft patients with secondary alveolar bone grafts using iliac crest bone grafts were included in this study, 10 males and 8 females ranging in ages from 6–22 years. Full history taking, operative details, and follow up to one year postoperatively, early and late postoperative complications reported and analyzed.Results: the iliac bone was reliable as a donor site for bone grafting of the alveolar cleft, the success rate was 11/18, also 5/18 had success from the second interference, the overall complications were acceptable.Conclusions: the anterior iliac crest is one of the best sites for autogenous bone graft for treatment of secondary alveolar cleft; it gives a big volume of highly vascular cancellous bone, with accepted range of postoperative complications

A multi-criteria trust-enhanced collaborative filtering algorithm for personalized tourism recommendations

The exponential growth of online information has LED to significant challenges in navigating data overload, particularly in the tourism industry. Travelers are overwhelmed with choices regarding destinations, accommodations, dining, and attractions, making it difficult to select options that best meet their needs. Recommender systems have emerged as a promising solution to this problem, aiding users in decision-making by providing personalized suggestions based on their preferences. Traditional collaborative filtering (CF) methods, however, face limitations, such as data sparsity and reliance on single rating scores, which do not fully capture the complexity of user preferences. This study proposes a hybrid multi-criteria trust-enhanced CF (HMCTeCF) algorithm to improve the accuracy and robustness of tourism recommendations. HMCTeCF improves the quality of recommendations by integrating multi-criteria user preferences with trust relationships among users and between items. Experimental results using real-world datasets, including Restaurants-TripAdvisor and Hotels-TripAdvisor, demonstrate that HMCTeCF outperforms benchmark CF-based recommendation methods. It achieves higher prediction accuracy and coverage rate, effectively addressing the data sparsity problem. This innovative algorithm facilitates a more personalized and enriching travel experience, particularly in scenarios with limited user data. The findings highlight the importance of considering multiple criteria and trust relationships in developing robust recommendation systems for the tourism industry

The effectiveness of minimally-invasive corticotomy-assisted orthodontic treatment of palatally impacted canines compared to the traditional traction method in terms of treatment duration, velocity of traction movement and the associated dentoalveolar changes: A randomized controlled trial [version 1; peer review: 2 approved]

Objective: To evaluate the effectiveness of a minimally-invasive corticotomy-assisted treatment of palatally impacted canines (PICs) compared with the traditional method by evaluating treatment time, the velocity of movement, and the associated dentoalveolar changes. Materials and methods: Forty-six patients with palatally or mid-alveolar upper impacted canines were recruited and distributed into two groups: the corticotomy-assisted traction group (CAT group, mean age: 20.39±2.27 years) and the traditional treatment group (TT group, mean age: 20.26±2.17 years). The closed surgical approach was used in both study groups. The velocity of traction movement, traction duration and overall treatment duration were evaluated clinically. In addition, the bone support ratios and the amount of root resorption were assessed on cone-beam computed tomography (CBCT) images. Results: At the end of treatment, significant differences were found between the two groups regarding the velocity of traction movement, traction time, and overall treatment time (P<0.05). The mean velocity of traction movement in the CAT group was greater than the TT group (x velocity =1.15±0.35 mm/month; 0.70±0.33 mm/month, P=0.027, respectively). The duration of the active traction and the overall orthodontic treatment in the CAT group were significantly shorter than the TT group by 36% and 29%, respectively. The mean bone support ratios of the aligned canines did not differ significantly between the two groups (88% vs. 89% in the CAT and TT groups, respectively). No significant differences were found between the two groups regarding the mean amount of root resorption on the adjacent laterals (x resorption = 1.30±1.18 mm; 1.22±1.02 mm, P=0.612, in CAT and TT groups, respectively). Conclusions: The traction movement velocity of the palatally impacted canines can be increased using minimally-invasive corticotomy-assisted orthodontic treatment. The side effects of the acceleration procedure were minimal and almost similar to those of the traditional technique

The relationship

Background and aim of the study: Anti-müllerian hormone (AMH) is a dimeric glycoprotein, which is secreted exclusively by granulose cells of primary, preantral, and small antral follicles (4–6 mm). Women with polycystic ovary syndrome (PCOS) have a 2- to 3-fold increase in the serum AMH concentration, which corresponds to the 2- to 3-fold increase in the number of small follicles seen in PCOS. The aim of this study was to assess the relationship between AMH and the clinical, biochemical and sonographic parameters in women with PCOS. Study design: In this prospective observational study, serum AMH was measured in 200 PCOS women attending 2 fertility clinics in Minia, Egypt. The relationship between AMH and the clinical, biochemical and sonographic parameters of PCOS was studied. Results: AMH levels were found to have significant positive correlation with cycle length (r = 0.706, P < 0.01), modified Ferriman Gallwey (FG) score for hirsutism (r = 0.329, P < 0.01), mean ovarian volume (r = 0.498, P < 0.01), antral follicle count (AFC) (r = 0.963, P < 0.01) and total testosterone (r = 0.272, P < 0.01). Conclusion: In conclusion, AMH is strongly correlated with the clinical, biochemical and sonographic features of PCOS

Keefektifan membaca al-qur’an bagi kesehatan jiwa lanjut usia di lembaga kesejahteraan sosial pondok Ma’arif Muslimin Padangsidimpuan Utara

Penelitian ini merupakan upaya untuk mengetahui rutinitas kegiatan membaca Al-Qur’an yang dilaksakan oleh para Lanjut Usia yang tinggal di Lembaga Kesejahteraan Sosial Pondok Ma’arif Muslimin Padangsidimpuan dan seperti apa metode yang mereka terapkan dalam membaca Al-Qur’an serta apa manfaat/faidah bagi kesehatan jiwa mereka setelah rutin mengikuti kegiatan membaca Al-Qur’an yang dilaksanakan di Lembaga Kesejahteraan Sosial Pondok Ma’arif Muslimin Padangsidimpuan. Rumusan masalah dalam penelitian ini Bagaimana kegiatan yang dilakukan lanjut usia dalam membaca Al-Qur’an di Lembaga Kesejahteraan Sosial Pondok Ma’arif Muslimin Padangsidimpuan serta Bagaimana manfaat/faedah membaca Al-Qur’an bagi kesehatan jiwa Lanjut Usia di Lembaga Kesejahteraan Sosial Pondok Ma’arif Muslimin Padangsidimpuan. Penelitian ini merupakan penelitian lapangan sedangkan pendekatan yang peneliti gunakan adalah pendekatan kualitatif dengan analisis deskriptif. Tekhnik pengumpulan data yang digunakan peneliti yaitu terdiri dari observasi dan wawancara. Selanjutnya tekhnik keabsahan data menggunakan triangulasi sumber dan triangulasi metode. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa ada faidah/manfaat yang dirasakan terhadap kesehatan jiwa Lanjut Usia ketika rutin melaksanakan kegiatan membaca Al-Qur’an yang dilakukan Lanjut Usia di Lembaga Kesejahteraan Sosial Pondok Ma’arif Muslimin Padangsidimpuan, yaitu mereka ada yang merasakan lebih tenang setelah membaca Al-Qur’an dan ada juga yang merasa lebih dekat dengan Allah SWT, namun ada juga Lanjut Usia yang juga rutin membaca Al-Qur’an namun tidak merasakan faidah/manfaat terhadap kesehatan jiwa mereka sehingga masih merasakan kegelisahan, cemas dan masih malas beribadah kepada Allah SWT

The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial

Background: Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI. Objective: The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome. Materials and Methods: Four hundred patients undergoing their first IVF/ICSI cycle in two IVF units in Minia, Egypt were randomly selected to undergo either endometrial injury in luteal phase of preceding cycle (intervention group) or no treatment (control group). Primary outcome wasthe implantation and live birth ratesWhile the secondary outcome was clinical pregnancy, miscarriage, multiple pregnancy rates, pain and bleeding during and after procedure. Results: Implantation and live birth rates were significantly higher in intervention compared with control group (22.4% vs. 18.7%, p=0.02 and 67% vs. 28%, p=0.03), respectively. There was also a significant reduction in miscarriage rate in intervention group (4.8% vs. 19.7%, respectively, p<0.001). Conclusion: Endometrial injury in preceding cycle improves the implantation rate and live birth rate and reduces the miscarriage rate per clinical pregnancy in patients undergoing their first IVF/ICSI cycl

Does laparoscopy still has a role in modern fertility practice?

Background: More than 3 decades after the introduction of in vitro fertilization (IVF) and despite the improved success rates of assisted reproductive technologies, the argument for performing laparoscopy as a part of the infertility workup still stands. Objective: To evaluate the role of laparoscopy&plusmn;hysteroscopy in diagnosis and management of infertility in our setting in view of modern fertility practice. Materials and Methods: This case control study was carried out on 600 infertile women subjected to laparoscopy or combined laparoscopy and hysteroscopy at endoscopy unit in Minia University Hospital, Egypt during the period from January 2012 to December 2014. Results: The causes of infertility as identified by laparoscopy&plusmn;hysteroscopy were polycystic ovary syndrome (25.1%), tubal factor (30%), uterine cause (4%), and endometriosis (2.7%). No cause was identified in 38.2% of cases. Based on operative findings, women were treated with different options. Expectant management was used in 92 cases (15.3%). Ovulation induction with anti-estrogens or gonadotropins was used in 372 cases (62%). Sixty cases (10%) had intrauterine insemination and sixty four cases (10.7%) underwent in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) treatment. Within 1 yr after laparoscopy, 180 cases achieved pregnancy (30%). The most favorable outcome was recorded in women with unexplained infertility (36.7% of cases got pregnant) followed by women with polycystic ovary syndrome (27.8%). Participants with uterine and tubal infertility factor achieved pregnancy in 25% and 22.8% of cases, respectively. The worst outcome was recorded in women with endometriosis. Conclusion: Laparoscopy still has an important role in the diagnosis and treatment of infertility

Ma'rifatu al Shahabat [1]

322 hal.; 24 c