The 3XMM/SDSS Stripe 82 Galaxy Cluster Survey: Cluster catalogue and discovery of two merging cluster candidates

We present a galaxy cluster survey based on XMM-Newton observations that are located in Stripe 82 of the Sloan Digital Sky Survey (SDSS). The survey covers an area of 11.25 deg$^2$. The X-ray cluster candidates were selected as serendipitously extended detected sources from the third XMM-Newton serendipitous source catalogue (3XMM-DR5). A cross-correlation of the candidate list that comprises 94 objects with recently published X-ray and optically selected cluster catalogues provided optical confirmations and redshift estimates for about half of the candidate sample. We present a catalogue of X-ray cluster candidates previously known in X-ray and/or optical bands from the matched catalogues or NED. The catalogue consists of 54 systems with redshift measurements in the range of 0.05-1.19 with a median of 0.36. Of these, 45 clusters have spectroscopic confirmations as stated in the matched catalogues. We spectroscopically confirmed another 6 clusters from the available spectroscopic redshifts in the SDSS-DR12. The cluster catalogue includes 17 newly X-ray discovered clusters, while the remainder were detected in previous XMM-Newton and/or ROSAT cluster surveys. Based on the available redshifts and fluxes given in the 3XMM-DR5 catalogue, we estimated the X-ray luminosities and masses for the cluster sample. We also present the list of the remaining X-ray cluster candidates (40 objects) that have no redshift information yet in the literature. Of these candidates, 25 sources are considered as distant cluster candidates beyond a redshift of 0.6. We also searched for galaxy cluster mergers in our cluster sample and found two strong candidates for newly discovered cluster mergers at redshifts of 0.11 and 0.26. The X-ray and optical properties of these systems are presented.Comment: 17 pages, 12 figures, accepted for publication in A&A, revised version after language editin

Adsorption Refrigeration Technologies

This chapter introduces a comprehensive overview about the principles, challenges and applications of adsorption refrigeration systems (ARSs), as a promising sustainable solution for many of cooling and heating applications. In addition to the features and the basics of ARSs, the following topics have been covered such as characteristics of working pairs, trends in improving the heat and mass transfer of the adsorber; advanced adsorption cycles and performance and operational data of some adsorption refrigeration applications. In some details, the operating range and the performance of ARSs are greatly affected by the employed working adsorbent/refrigerant pairs. Therefore, the study, development and optimum selection of adsorbent/refrigerant pairs, particularly the composite adsorbents, can lead to improving the performance and reliability of ARSs. Regarding the enhancement of heat and mass transfer in the adsorbent bed, two methods are commonly used: one is the development of adsorbents through different coating technologies or new materials such as metal-organic frameworks, and the second is the optimization of the adsorber geometrical parameters and cycle modes. Finally, a brief on some adsorption chillers applications have started to find their share in markets and driven by solar or waste heats

Prevention of Ventilator-Associated Pneumonia: Zero-VAP implementation: review article

Background: Mechanical ventilation via an endotracheal tube (ETT) or tracheostomy can lead to a condition known as ventilator associated pneumonia (VAP). Up to 20% of all nosocomial infections in pediatric care facilities following blood stream infections are most commonly brought on by Ventilator Associated Pneumonia (VAP). Pediatric intensive care units (PICUs) and neonatal intensive care units (NICUs) had very different rates of VAP infections per 1000 ventilator days. Patients who have VAP are more likely to have a longer stay in the hospital and a higher rate of morbidity and mortality. If implemented, "Zero VAP" was found to be an all-encompassing strategy for prevention of higher rates of VAP in Spain. This strategy could be widely used for more prevention of VAP globally.Objective: To evaluate the role of the Spanish "Zero- VAP" bundle in reduction of VAP in PICU. Conclusion: Zero-VAP compromises of many levels among health working personnel and system, it gives a clear description of steps, approach, preventive actions to minimize incidence of VAP among ICUs that could be used globally

Induciranje pluripotentnih matičnih stanica upotrebom mRNA: učinak valproične kiseline, 5-azacitidina i askorbinske kiseline

In the bourgeoning fields of tissue engineering and regenerative medicine, induced pluripotent stem cells (iPSCs) technology with gene therapy are promising candidates for alternative stem cell source and cell transplantation. In this study, small molecules as anti-oxidant; ascorbic acid (ASA), histone deacetylase inhibitors (HDACi); Valproic acid (VPA), and DNA methyltransferase inhibitors (DNMTi); 5-Azacytidine (5-AzaC) were examined during the generation of murine iPSCs using mRNA of Yamanaka factors from mouse embryonic fibroblasts (MEFs). These modulators were selected based on their well-known effect on the epigenetic status and chromatin modification during early reprogramming. iPSC generation was performed by using synthesized mRNAs of Yamanaka factors Oct4, Sox2, c-Myc, and Klf4 (OSCK) as a standard reprogramming strategy. Both morphological changes and the expression level of the pluripotency markers were examined. 5-AzaC with 1 μM concentration has a slightly toxic effect on the cells, affecting its proliferation and growing efficiency. In contrast, the use of VPA or ASA led to a two-fold increase in the number of iPSC colonies. The iPSCs cultured with the addition of VPA or ASA showed a high expression of the tested pluripotency markers, with a significant increase, more than that of the cells cultured with the addition of 5-AzaC. These findings shed light on the role of ASA, VPA, and 5-AzaC during murine iPSCs generation using a mRNA reprogramming strategy.Ubrzani razvoj u područjima tkivnog inženjerstva i regenerativne medicine, potaknuo je tehnologiju pluripotentnih matičnih stanica (iPSCs) koja zajedno s genskom terapijom predstavlja obečavajući izvor matičnih odnosno transplantacijskih stanica. U ovom su radu, za vrijeme stvaranja mišjih iPSC-a upotrebom mRNA Yamanaka faktora od mišjih embrionalnih fibroblasta (MEF), istraženi učinci različitih modulatora: malih molekula kao antioksidansa, askorbinske kiseline (ASA), inhibitora histonske deacetilaze (HDACi), valproične kiseline (VPA), inhibitora DNA metiltransferaze (DNMTi) i 5-azacitidina (5-AzaC). Ovi su modulatori odabrani zbog njihova dobro poznatog učinka na epigenetski status i modifikaciju kromatina za vrijeme ranog reprogramiranja. Stvaranje iPSC-a postignuto je upotrebom sintetiziranih mRNA Yamanaka faktora Oct4, Sox2, c-Myc i Klf4 (OSCK). Istražene su i morfološke promjene i razina ekspresije markera pluripotencije. 5-AzaC s koncentracijom od 1 μM imao je mali toksičan učinak na stanice, utječući na proliferaciju i njihov rast. Nasuprot tome, upotreba VPA-a ili ASA-e dovela je do dvostrukog povećanja broja iPSC kolonija. iPSC kultura s dodatkom VPA-a ili ASA-e pokazala je visoku ekspresiju testiranih markera pluripotencije, sa znakovitim višom razinom u odnosu na stanice kojima je dodan 5-AzaC. Ovi rezultati rasvjetljuju ulogu ASA-e, VPA-a i 5-AzaC-a za vrijeme stvaranja mišjih iPSC-a primjenom strategije reprogramiranja mRNA

Employing Hot-Melt Extrusion Technology to Enhance the Solubility of Cannabidiol (CBD)

Corresponding author (Pharmaceutics and Drug Delivery): Iman Taha, [email protected]://egrove.olemiss.edu/pharm_annual_posters_2022/1020/thumbnail.jp

The serum thyroid hormone profile in mechanically ventilated children: Does euthyroid sick syndrome exist?

Background: The term "euthyroid sick syndrome" refers to alterations in thyroid function testing during critical illness. Mechanically ventilated children's thyroid hormone levels may be altered, although the reason for this remains a mystery.Objective: This study was aimed to evaluate thyroid hormone profile in mechanically ventilated children and their correlation with mortality.Patients and Methods: Thirty-four mechanically ventilated children were enrolled in a prospective cohort study. On the first and third days of mechanical ventilation, serum TSH, FT3, FT4 and reverse T3 were measured.Results: The mean age of the studied patients was of 31.06 ± 35.94 months. After three days of mechanical ventilation, the serum levels of FT3 and FT4 in the blood were significantly lower than the serum levels on the first day. The serum reverse T3 levels increased significantly on the third day of mechanical ventilation compared to the first day. There was a statistically significant increase in the number of patients with low FT3 and FT4 serum levels on the third day compared to the first day. Twenty-two patients (64.7%) died, and the frequency of low FT3 among dead patients was signiisignificantlycantly higher than among surviving patients.Conclusions: It could be concluded that the mechanically ventilated children had signs of euthyroid sick syndrome, shown by low levels of FT3 and FT4 and a rise in rT3 without a compensatory rise in TSH. Serum FT3 and FT4 decreased, but reverse T3 increased, on the third day of mechanical ventilation compared to the first day. Patients who had low FT3 levels died at a higher rate