Citrus aurantium Blossom and Preoperative Anxiety

Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M, Akhlaghi M - Citrus aurantium Blossom and Preoperative Anxiety. Background and objectives: Reducing anxiety is very important before operation. Preoperative visit and use of premedication are popular methods to achieve this goal, but the role of anxiolytic premedication remains unclear and postoperative side-effects may result from routine premedication. Citrus aurantium is used as an alternative medicine in some countries to treat anxiety, and recently the anxiolytic role of this medicinal plant was established in an animal model study. The aim of this study was to assess the anxiolytic effect of Citrus aurantium blossom on preoperative anxiety. Methods: We studied 60 ASA I patients undergoing minor operation. In a randomized double-blind design, two groups of 30 patients received one of the following oral premedication two hours before induction of anesthesia: 1) Citrus aurantium blossom distillate 1 mL.kg(-1), (C-group); 2) Saline solution 1 mL.kg(-1) as placebo (P-group). Anxiety was measured before and after premedication using the Spielberger state-trait anxiety inventory (STAI-state) and the Amsterdam preoperative anxiety and information scale (APAIS) before operation. Results: After premedication, both the STAI-state and the APAIS scales were decreased in C-group (p < 0.05); while exhibiting no significant changes in P-group. Conclusions: Citrus aurantium blossom may be effective in terms of reduction in preoperative anxiety before minor operation

Citrus aurantium Blossom and Preoperative Anxiety

Summary: Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M, Akhlaghi M – Citrus aurantium Blossom and Preoperative Anxiety. Background and objectives: Reducing anxiety is very important before operation. Preoperative visit and use of premedication are popular methods to achieve this goal, but the role of anxiolytic premedication remains unclear and postoperative side-effects may result from routine premedication. Citrus aurantium is used as an alternative medicine in some countries to treat anxiety, and recently the anxiolytic role of this medicinal plant was established in an animal model study. The aim of this study was to assess the anxiolytic effect of Citrus aurantium blossom on preoperative anxiety. Methods: We studied 60 ASA I patients undergoing minor operation. In a randomized double-blind design, two groups of 30 patients received one of the following oral premedication two hours before induction of anesthesia: 1) Citrus aurantium blossom distillate 1 mL.kg-1 (C-group); 2) Saline solution 1 mL.kg-1 as placebo (P-group). Anxiety was measured before and after premedication using the Spielberger state-trait anxiety inventory (STAI-state) and the Amsterdam preoperative anxiety and information scale (APAIS) before operation. Results: After premedication, both the STAI-state and the APAIS scales were decreased in C-group (p < 0.05); while exhibiting no significant changes in P-group. Conclusions: Citrus aurantium blossom may be effective in terms of reduction in preoperative anxiety before minor operation

Citrus aurantium Blossom and Preoperative Anxiety

SummaryBackground and objectivesReducing anxiety is very important before operation. Preoperative visit and use of premedication are popular methods to achieve this goal, but the role of anxiolytic premedication remains unclear and postoperative side-effects may result from routine premedication. Citrus aurantium is used as an alternative medicine in some countries to treat anxiety, and recently the anxiolytic role of this medicinal plant was established in an animal model study. The aim of this study was to assess the anxiolytic effect of Citrus aurantium blossomon preoperative anxiety.MethodsWe studied 60 ASA I patients undergoing minor operation. In a randomized double-blind design, two groups of 30 patients received one of the following oral premedication two hours before induction of anesthesia: 1) Citrus aurantium blossom distillate 1mL.kg-1 (C-group); 2) Saline solution 1mL.kg-1 as placebo (P-group). Anxiety was measured before and after premedication using the Spielberger state-trait anxiety inventory (STAI-state) and the Amsterdam preoperative anxiety and information scale (APAIS) before operation.ResultsAfter premedication, both the STAI-state and the APAIS scales were decreased in C-group (p<0.05); while exhibiting no significant changes in P-group.ConclusionsCitrus aurantium blossom may be effective in terms of reduction in preoperative anxiety before minor operation

Effects of Sesamum indicum L. on fibrinogen and factor 7 in hypercholesterolemic rabbits

زمینه و هدف: فعالیت بیش از حد فاکتورهای هموستاتیک به عنوان عوامل خطر در بیماری های قلبی-عروقی شناخته شده اند. هدف از این مطالعه بررسی اثر کنجد و روغن کنجد بر میزان فیبرینوژن و فاکتور 7 در خرگوش های مصرف کننده کلسترول بالا بوده است. روش بررسی: در این مطالعه تجربی تعداد 32 سر خرگوش نر به طور تصادفی به چهار گروه آزمایشی هشت تایی تقسیم شدند. طی یک دوره 60 روزه، گروه اول غذای معمولی، گروه دوم غذای پر کلسترول (1)، گروه سوم غذای پر کلسترول به همراه کنجد (10) و گروه چهارم غذای پر کلسترول به همراه روغن کنجد (5) دریافت نمودند. میزان فاکتور هفت و فیبرینوژن سرم در زمان قبل از شروع آزمایش و بعد از پایان ماه دوم تعیین و در گروه های مختلف به کمک آزمون های آماری ANOVA و شفه با یکدیگر مقایسه شدند. یافته ها: در ابتدای دوره میانگین فاکتورهای بیوشیمیایی در بین گروههای مورد مطالعه تفاوت معنی داری نداشتند ولی میزان فیبرینوژن در گروه پرکلسترول نسبت به رژیم پایه افزایش معنی داری پیدا کرد (05/0

The Comparison of the anti Limnatis nilotica effets of albendazole and some of the Iranian medicinal plants

Background: Aquatic leech invade mucosal membrane and causes anemia. Until now, there is not any commercial effective drug for controlling of this parasite. In this experimental study, investigated the effect of some chemical and herbal drugs against leech (Limnatis nilotica). Methods: Methanolic extract of Artemisia kermanensis and Artemisia spp and hydroalcoholic extracts of Scrophularia deserti, Quercus brantii and Achillea spp was prepared. . Each drugs was tested in one group with 9 replicates. Each leech preserve in one separated jar and drugs were added to each jar. Albendazole used as commercial anti-parasite and distilled water was used as negative control. The movement and respond of each Leech was recorded for 720 minutes. Also, the leeches were monitored for paralysis and death in this duration. Results: In this study, leeches receiving albendazol (600mg) died at 138 min after exposure with albendazol. But exposure with methanolic extracts of Artemisia kermanensis (600 mg), Artemisia spp (600 mg) and hydroalcoholic extracts of Quercus brantii (600 mg), Achillea spp (600 mg) and Scrophularia deserti (600 mg) have no effect on liviability of leeches. Methanolic extract of Artemisia kermanensis with doses of 1800 and 2400 mg, caused death in leeches after 720, 635 and 188 minutes, respectively. Also, methanolic extracts of Arthemisia spp with doses of 1200, 1800 and 2400 mg, caused death in leeches after 720 , 600 and 601 minutes, respectively. Conclusion: This study demonstrated that the herbal drugs that used in this study with compare to albendazole have no considering effect on Limniatis nilotica

Anti-cancer effect of fresh and aged garlic

Background: Garlic components may change due to its enzymes activity such as alliance. In this research the effect of three months old garlic on the growth of WEHI-164 fibrosarcoma cells was examined in comparison with fresh garlic in Balb/c mice. Material and Methods: In this interventional study 40 female inbred Balb/c mice were designated into 5 groups. WEHI-164 cells were injected subcutaneously in the chest of animal. Two weeks before and three weeks after injection of cancer cells, 0.2 cc of normal saline or 20 mg/kg extracts of fresh or three months old garlic was injected intraperitoneally (IP) to mice. Five days after cells&rsquo; injection until day 21, every other day, and the mean size of tumors was measured and compared with each other, using ANOVA test. The antioxidant potential of extracts and the amount of total phenolic were also measured. Results: The amount of phenolic compounds in fresh garlic extract was 12.61mg/g and in three months old garlic was 2.89 mg/g. The efficiency of fresh garlic (35.63) was further compared with three month old garlic (10.2) in prevention of oxidation (p<0.05). The mean size of tumors in groups which received fresh garlic was smaller than that of control group. This tumor size was increased by time, so that a significant difference in mention groups could be seen on days 17, 19 and 21 (p=0.001). Injection of 3-months old garlic had no effect on inhibition of growth of cancer cells compared to control group (P=0.61). Conclusion: Findings showed that garlic consumption might have important role in control and prevention of fibrosarcoma growth. But along with time the beneficial effect of garlic on cancer cells is reduced. Therefore, fresh garlic consumption is recommended

Cardioprotective effect of ethanolic leaf extract of Melissa officinalis L against regional ischemia-induced arrhythmia and heart injury after five days of reperfusion in rats

Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized through HPLC analysis. Adult male rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion. The rats were randomized to receive vehicle or M. officinalis as follows: group I served as saline control with ischemia, groups II, III and IV received different doses of MOE- (intragastric, 25, 50 or 100 mg/kg respectively), by oral gavage daily for14 days prior to ischemia Administration of M. officinalis significantly improved ischemia/reperfusion (I/R)-induced myocardial dysfunction by reduction of infarct size, episodes of ventricular tachycardia(VT) and ventricular ectopic beat(VEB and duration of VT as compared to control group, stabilized ST segment changes, QTc shortening, increased the R and T wave amplitudes and increased the heart rate during ischemia, increased the serum superoxide dismutase (SOD) activity and decreased serum lactate dehydrogenase (LDH), Troponin I (CTnI) and malondialdehyde (MDA) levels, 5 days after reperfusion. MOE-100mg/kg was the effective dose. Cinamic acid (21.81±1.26 mg/gr) was the main phenolic compound of plant sample. The ethanol extract of M. officinalis was observed to exhibit cardioprotective effects against I/R injury, probably due to antioxidant properties. Keywords Melissa officinalis; Ischemia; Reperfusion injury; Heart; Ra

Flor de Citrus aurantium e ansiedade pré-operatória

JUSTIFICATIVA E OBJETIVOS: Reduzir a ansiedade é muito importante antes da operação. A visita no pré-operatório e a utilização de pré-medicação são os métodos mais populares para se atingir esse objetivo, mas o papel da pré-medicação ansiolítica permanece incerto e os efeitos colaterais no pós-operatório podem partir de uma pré-medicação de rotina. Citrus aurantium é usado como medicina alternativa em alguns países para tratar a ansiedade. Recentemente, o papel ansiolítico dessa planta medicinal foi estabelecido em um estudo realizado em modelo animal. O objetivo deste estudo foi avaliar o efeito ansiolítico da flor de Citrus aurantium sobre a ansiedade pré-operatória. MÉTODOS: Foram estudados 60 pacientes ASA I submetidos a uma pequena cirurgia. Em um desenho randomizado e duplo-cego, dois grupos de 30 pacientes receberam uma das seguintes MPA oral duas horas antes da indução da anestesia: 1) Citrus aurantium destilado 1 mL.kg-1 (Grupo C); 2) solução salina 1 mL.kg-1 como placebo (Grupo P). A ansiedade foi medida antes e após pré-medicação com o Inventário de Ansiedade Traço-Estado (IDATE) e a Escala de Ansiedade e Informação Pré-Operatória de Amsterdam (APAIS) antes da operação. RESULTADOS: Após pré-medicação, tanto o IDATE quanto as escalas APAIS estavam diminuídos no Grupo C (p < 0,05), embora não tenham apresentado alterações significativas no Grupo P. CONCLUSÕES:Citrus aurantium pode mostrar-se eficaz na redução da ansiedade pré-operatória em cirurgias de pequeno porte

Comparing the Effect of Intranasal Lidocaine 4% with Peppermint Essential Oil Drop 1.5% on Migraine Attacks: A Double-Blind Clinical Trial.

BACKGROUND: Prevalence of migraine, as a chronic neurovascular disorder, was approximately 10.3 and 23.1% among men and women, respectively, mostly in people younger than 40 years old. Migraine is prevalent in different geographic areas worldwide. The present study was designed to compare the impact of intranasal lidocaine 4% and peppermint essential oil drop 1.5% on migraine attacks. METHODS: In this double-blind, parallel, randomized controlled trial, 120 adult patients with a diagnosis of migraine based on the International Headache Society criteria were treated with intranasal lidocaine drop 4% or peppermint essential oil drop 1.5% or placebo. Patients expressed their symptoms 5 and 15 min after dripping, and if they still had a headache after 15 min, they were given the second dose. Patients with a second dose of medication, 15 min later recorded their headache rate. All patients recorded their symptoms after 30 min. Symptoms of the patients were followed by a researcher through the phone and in-person after 2 months. Then, the questionnaires were filled. RESULTS: In the present study, there was a significant difference among groups in headache intensity after treatment (P < 0.001). In 40% of the patients in the peppermint oil and lidocaine groups, the intensity of headache decreased. In the placebo group, fewer patients responded highly to the treatment, whereas 41.5% of patients in the lidocaine group and 42.1% of patients in the peppermint oil group responded to the treatment considerably. CONCLUSIONS: Concerning the findings of the present study, nasal application of peppermint oil caused considerable reduction in the intensity and frequency of headache and relieved majority of patients' pain similar to lidocaine. On the basis of findings of this study, it can be concluded that nasal menthol, such as lidocaine, can be used to relieve migraine headaches. KEYWORDS: Headache; lidocaine; migraine attacks; peppermint oi