Classification of Cardiotocography Data with WEKA

Cardiotocography (CTG) records fetal heart rate (FHR) and uterine contractions (UC) simultaneously. Cardiotocography trace patterns help doctors to understand the state of the fetus. Even after the introduction of cardiotocograph, the capacity to predict is still inaccurate. This paper evaluates some commonly used classification methods using WEKA. Precision,Recall, F-Measrue and ROC curve have been used as the metric to evaluate the performance of classifiers. As opposed to some of the earlier research works that were unable to identify Suspicious and Pathologic patterns, the results obtained from the study in this paper could precisely identify pathologic and Suspicious cases. Best results were obtained from J48, Random Forest and Classification via Regression

Experience, challenges and lessons learnt from microsurgical clipping of intracranial aneurysms at an emerging neurosurgical centre

Objectives: To share our experience, challenges faced, lessons learnt and analyze the results of surgical management by microsurgical clipping of intracranial aneurysms at an emerging neurosurgical centre at Guru Gobind Singh medical college and hospital (GGSMC&H) Faridkot, Punjab. India. Material and Methods: This study includes all the patients who presented with the diagnosis of intracranial aneurysm on CT angiography and were treated with the microsurgical clipping,  between March 2017 to April 2019. Results: There was a total of 23 patients 11female and 12 male. Age range 32 to 85years. On admission 22 patients had SAH on CT scan and one was admitted after incidental detection of the aneurysm without SAH. The time interval between ictus and admission was 0-3 days in 13 patients, 3-14 days in 8 patients and more than 14 days in 1 patient. WFNS grade (gd) I-15 patients, gd II-2, gd III-2, gd IV-3 patients. Fisher gd I-nil, gd II-9, gd III-4, gd IV-9 patients. In 23 patients 27 Aneurysms were clipped. Distribution of location was Anterior Communicating-12, Distal Anterior Cerebral Artery- 4, Middle cerebral artery (MCA) Bifurcation-3, MCA trifurcation-1, Anterior Choroidal-1, Posterior Communicating (P-com) -1, Ophthalmic Internal Carotid Artery (OICA)-4 and three patients had associated multiple aneurysms. Size of aneurysms varied from < 02mm diameter in 2 patients, 2-25mm - 23 and, more than 25mm-2 aneurysms. There was intra op rupture in 2 cases. Post-operatively 2 patients developed hemiparesis, which recovered, nine patients developed vasospasm. Two patients developed chest related complications. One patient developed renal failure.  There were 8 deaths. Patients are on follow up since March 2017 till date. Conclusions: Intracranial aneurysms are challenging to manage due to their proximity to vital intracranial structures, and difficulty in securing intracranial proximal control. Thorough knowledge of intracranial anatomy of adjacent relations, arachnoid planes and skilful dissection is a key element for a successful outcome. Data collected from GGSMC & Hospital may not be representative of the entire state or country’s population. Therefore, a large-scale data collection is necessary to create our own database to ascertain the risk factors and preventive measures that are exclusive to our state and nation

Classification of Cardiotocography Data with WEKA

Cardiotocography (CTG) records fetal heart rate (FHR) and uterine contractions (UC) simultaneously. Cardiotocography trace patterns help doctors to understand the state of the fetus. Even after the introduction of cardiotocograph, the capacity to predict is still inaccurate. This paper evaluates some commonly used classification methods using WEKA. Precision,Recall, F-Measrue and ROC curve have been used as the metric to evaluate the performance of classifiers. As opposed to some of the earlier research works that were unable to identify Suspicious and Pathologic patterns, the results obtained from the study in this paper could precisely identify pathologic and Suspicious cases. Best results were obtained from J48, Random Forest and Classification via Regression

Machining Characteristics and Parametric Optimisation of Inconel 825 during Electric Discharge Machining

This paper presents the machining characteristics and parametric optimisation of Inconel 825 during die-sinking electrical discharge machining (EDM) process. This work considers seven input parameters out of which six are of three levels and one is of one level. Metal removal rate (MRR), tool wear rate (TWR) and surface roughness (SR) have been considered as performance measures. Before carrying out physical experimental runs, the experiments have been designed using Taguchi’s L36 (21 × 36) orthogonal array (OA). In order to identify the significant input parameters, Analysis of Variance has been employed on the experimental data. Discharge current, pulse-on-time, tool material and tool electrode lift time are found as significant input parameters. The effects of these significant parameters on the performance measures have been presented using Taguchi\u27s technique. After machining, study of surface characteristics of the electric discharged machined surface has been carried out using scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDXS) and X-ray diffraction (XRD). These studies help in obtaining the information pertaining to topography of the machined surface, material transfer from tool and dielectric to the machined surface, and presence of extra element and their different phases at the machined surface. It has been found from the research that Carbon, Oxygen, Iron, Nickel, Chromium and little amount of Molybdenum are transferred to the surface of work piece. Further, for the best yield of the process, the optimal combination of input parameters has been obtained and reported using Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) as a multi-objective optimisation technique. Consideration of two different dielectric fluids and three different electrode materials is the novelty of the work

Intra-cranial malignant peripheral nerve sheath tumor of olfactory nerve: A case report and review of literature

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are one of the very rare high grade malignancies usually affecting extremities or trunk. Incidence is 1/Lac. Intra-cranial MPNSTs are even rarer, schwannomatous and commonly affecting cranial nerves VIII &VII). Intra-cranial MPNSTs are usually sporadic, arising de novo. The second most common mode of origin is from malignant transformation from pre-existing schwannomas or neurofibroma. We present an extremely rare and probably the first case of intra-cranial malignant peripheral nerve sheath tumor of the olfactory nerve in a non neurofibrosis patient with no prior history of irradiation

Cerebral pilocytic astrocytoma with spontaneous intratumoral haemorrhage in the elderly - a rare entity: A case report and review of the literature

Pilocytic astrocytomas (PA) are histologically are low-grade tumours, commonly found in the paediatric and young adult population. Although cases of adult and elderly pilocytic astrocytomas are described in the literature, they are quite uncommon. The rate of PAs with spontaneous bleeding is very less, with a high occurrence in children than in adults, moreover, that is in cerebellar PAs. Cerebral PAs with intratumoral haemorrhage in the older age group is extremely rare. We present a case of a 60-year female presenting with acute neurological compromise resulting from an acutely haemorrhagic Left temporal pilocytic astrocytoma. She was managed surgically with evacuation of tumoral haemorrhages, as well as resection of the tumour. Postoperatively the patient made a remarkable recovery

In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance

Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher expression of these transporters has been correlated with an unfavorable response to chemotherapy, transporter expression does not necessarily correlate with function. In this study, we characterized the pharmacological properties of [18F]AVT-011, a new PET radiotracer for imaging transporter-mediated MDR in tumors.AVT-011 was radiolabeled with 18F and evaluated with PET imaging in preclinical models. Transport of [18F]AVT-011 by ABCB1 and/or ABCG2 was assessed by measuring its uptake in the brains of wild-type, Abcb1a/b-/-, and Abcg2-/- mice at baseline and after administration of the ABCB1 inhibitor tariquidar (n = 5/group). Metabolism and biodistribution of [18F]AVT-011 were also measured. To measure ABCB1 function in tumors, we performed PET experiments using both [18F]AVT-011 and [18F]FDG in mice bearing orthotopic breast tumors (n = 7-10/group) expressing clinically relevant levels of ABCB1.At baseline, brain uptake was highest in Abcb1a/b-/- mice. After tariquidar administration, brain uptake increased 3-fold and 8-fold in wild-type and Abcg2-/- mice, respectively, but did not increase further in Abcb1a/b-/- mice. At 30 min after injection, the radiotracer was > 90% in its parent form and had highest uptake in organs of the hepatobiliary system. Compared with that in drug-sensitive tumors, uptake of [18F]AVT-011 was 32% lower in doxorubicin-resistant tumors with highest ABCB1 expression and increased by 40% with tariquidar administration. Tumor uptake of [18F]FDG did not significantly differ among groups.[18F]AVT-011 is a dual ABCB1/ABCG2 substrate radiotracer that can quantify transporter function at the blood-brain barrier and in ABCB1-expressing tumors, making it potentially suitable for clinical imaging of ABCB1-mediated MDR in tumors

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

BioMed2007-38011 DESIGN AND DEVELOPMENT OF A FOOT CONTROLLED MOBILITY DEVICE

ABSTRACT In the recent years, the focus of ever-progressing scientific and technological advancements is continuously drifting towards the rehabilitation engineering. The development in the field of "mobility aid" has led to research, which has transformed conventional manual attendant-style wheelchairs to electricpowered wheelchairs with improved control through joysticks, sensors and micro-controllers. Consumers with limited mobility (pain in legs, permanent injury etc.) and elderly users, who cannot independently operate a powered wheelchair due to their hands impairment, have to rely upon third-party assistance during transfers to secure their wheelchair. Most 'Mobility Assistance Equipment' manufacturers for the orthopaedically handicapped individuals have not been able to adequately address such problems. With mobility being a key factor in all aspects of human life, this project proposes a design to allow hands impaired people, who cannot walk to orient themselves in, and navigate through, complex environments with the help of foot controlled wheel chair. This paper presents design and development of a batterypowered wheelchair that will be operated by foot controls, based upon the need assessments of such consumers. The Electronic System is a basic speed control circuit designed and provides for four motion configurations -reverse, stop, slow, and fast