Hypnosis as an Alternative to General Anesthesia for Orthopedic Hand Surgery: A Case Report

The effectiveness of psychological techniques such as patient education, cognitive and behavioral interventions, relaxation techniques, hypnosis, therapeutic suggestion interventions, and emotion-focused interventions has been assessed through the outcomes of postoperative pain, perioperative anxiety, quality of life, and recovery in adults. In this case presentation, we introduce using of hypnosis as an approach to pain control in hand surgery

The Evaluation of Web-based Software for Sending Medication Adherence Reminders in Infectious Disease Patients

Background: Incomplete drug adherence can cause problems for patients as well as physicians and cost billions of dollars each year throughout the globe. One of the tools that can help patients and physicians is short text messaging (SMS). This research aims to design and implement the first web-based software specified for medicine use in Iran and test its feasibility to send short message reminders to infectious disease patients and also patient acceptance, and satisfaction. Methods: In this qualitative action research, initially a software was designed for sending text messages to patients and then 30 patients were chosen purposefully in four weeks and were sent short text messages exactly based on clinicians’ prescribed order. After completing a treatment course, each patient was interviewed and questions were asked to assess patient’s satisfaction. Results: The result showed that all of the patients who received the text messages, believed that this method in comparison to their previous experience has helped them to use their medicine on time and correctly and they were keen to use this service in the future. Conclusion: Short text messaging can be used as an effective tool to remind patients to take their medicine correctly, and increase their satisfaction and compliance. Keywords: Reminder system, Drug utilization, Text messaging, Cellular phone, Infectious disease

Evaluating The Association Between Serum Hsp27 Antibody and Hypertension in Patients without Underlying Cardiovascular Disease

Introduction: An association between heat shock protein 27 (Hsp27) antigen with cardiovascular risk factors has been shown previously. Furthermore, higher levels of serum anti-HSP27 antibodies are also related to higher cardiovascular morbidity and mortality. In the current study, we looked at the relationship between serum Hsp27 antibodies and hypertension, as an important cardiovascular risk factor, in individuals without evidence of cardiovascular disease (CVD).Methods: A sub-population of hypertensive patients (HTN+) without underlying CVD were recruited from the Mashhad stroke and atherosclerosis heart disease (MASHAD) study to assess the association between serum Hsp27 antibodies and hypertension; independent of other cardiovascular risk factors. A total of 1599 people were studied of whom 288 individuals had hypertension and 1311 were used as controls (HTN-).Results: Mean serum Hsp27 antibody titers were 0.20 (0.27) OD in the whole population sample and was not significantly different in the normotensive (HTN-) compared to HTN+ individuals with different degrees of hypertension.Conclusion: There were no significant associations between serum anti-Hsp27 concentrations and either the presence or severity of hypertension. Future studies are warranted to explore the association of anti-Hsp27 antibody and antigen levels and other cardiovascular risk factors

Determination of the genetic variation in Ajowan (Carum Copticum L.) populations using multivariate statistical techniques Determinação da variação genética em populações de Ajowan (Carum Copticum L.) usando técnicas estatísticas multivariadas

The experiment was conducted at Urmia University, to assess genetic diversity in populations of Iranian Ajwain based on agronomical and morphological characteristics. Ten populations, collected from different regions, were evaluated in a completely randomised design with eight to ten replications. Various agronomical and morphological characteristics were measured, including stem diameter, plant height, number of branches, number of leaves and leaflets, number of umbels, number of umbellules per inflorescence, number of flowers per umbellule with inflorescence, leaf length, average internodal distance, shoot dry matter, one hundred seed weight, number of seeds, biological production, single plant yield, length of ripening period and harvest index. Among the characteristics studied, a high coefficient of variation was observed for the number of seeds (197.58), single plant yield (57.56) and shoot dry matter (56.28). Broad-sense heritability for all of the characteristics studied was moderate to high, and varied from 0.41 to 91% with the exception of the number of branches, length and ripening period, which had low broad-sense heritability. Cluster analysis using Ward's method classified ten populations of Ajwain into four groups. Principal Component Analysis (PCA), using 18 agronomical and morphological characteristics, indicated that the first two principal components (PCs) with eigenvalues of more than one, accounted for 74.5% of the total variance. The results of the PCA were consistent with those of the cluster analysis. The present study demonstrates that populations of Ajwain from Iran displayed a considerable diversity of agronomical and morphological characteristics that are useful in germplasm management and for utilisation in improvement programs.<br>O experimento foi conduzido na Universidade de Urmia para avaliar a diversidade genética em populações iranianas de Ajowan, baseada em características agro-morfológicas. Dez populações, coletadas em diferentes regiões, foram avaliadas num delineamento inteiramente casualizado, com oito a dez repetições. Foram avaliadas várias características agro-morfológicas, como o diâmetro do caule, altura da planta, número de ramos, número de folhas e folíolos, número de umbelas, número de umbelas em uma inflorescência, número de flores por umbelas e inflorescência, comprimento da folha, média distância internodal, peso seco da parte aérea, peso de cem sementes, número de sementes, rendimento biológico, rendimento por planta única, duração do período de maturação e índice de colheita,. Entre as características estudadas, um coeficiente de variação alto foi observado para o número de sementes (197,58), rendimento por planta única (57,56) e peso seco da parte aérea (56,28). As herdabilidades de sentido amplo, para todas as características estudadas, foram de moderadas a altas, e variaram de 0,41a 91%, com excepção do número de ramos e das características de comprimento e período de maturação, que teve baixa herdabilidade de sentido amplo. A análise de agrupamento, utilizando o método de Ward, classificou as dez populações de Ajowan em quatro grupos. A análise do componente principal, usando 18 características agro-morfológicas indicou que os primeiros dois componentes principais (PCs), com valores próprios de mais que um, representaram 74,5% da variância total. Os resultados da PCA foram consistentes com os da análise de agrupamento. O presente estudo demonstra que as populações Ajowan do Irã apresentaram uma diversidade de características agro-morfológicas considerável, e que são úteis no manejo de germoplasma e em programas de melhoramento

A novel missense mutation in the TGF-β-binding protein-like domain 3 of FBN1 causes Weill–Marchesani syndrome with intellectual disability

Background: Weill–Marchesani syndrome (WMS) is a rare connective tissue disorder characterized by locus heterogeneity and variable expressivity. Patients suffering from WMS are described by short stature, brachydactyly, joint stiffness, congenital heart defects, and eye abnormalities. This disorder is inherited in two different modes; the autosomal dominant form of the disease occurs due to a mutation in FBN1, and the recessive form results from mutations in ADAMTS10, ADAMTS17, or LTP2 genes. Materials and Methods: The family recruited in this study was a consanguineous Iranian family with an intellectually disabled girl referred to the Sadra Genetics laboratory, Shahrekord, Iran. The clinical history of family members was investigated. Whole-Exome Sequencing (WES) for the proband was performed. Sanger sequencing was used to assess the segregation of candidate variants in the other family members. Results: Whole-exome sequencing analysis revealed a novel heterozygote mutation in the proband located at the third TGF-β-binding protein-like (TB) domain of the FBN1 gene (NM000138: c.2066A>G: (p. Glu689Gly), NP_000129.3, in exon 17 of the gene). Co-segregation analysis with Sanger sequencing confirmed this mutation in the affected members of the pedigree. Conclusion: Our findings represent an autosomal dominant form of specific WMS resulting from a substitution mutation in the FBN1 gene. In addition to the typical manifestations of the disorder, mild intellectual disability (ID) was identified in the 8-year-old proband. Given the fact that ID is primarily reported in ADAMTS10 mutated cases, this family was clinically and genetically a novel case