Numerical Investigation of the Performance of Kenics Static Mixers for the Agitation of Shear Thinning Fluids

The laminar flow of non-Newtonian fluids through a Kenics static mixer is investigated by using the CFD (Computational Fluid Dynamics) tool. The working fluids have a shear thinning behavior modeled by the Ostwald De Waele law. We focus on the effect of Reynolds number, fluid properties, twist angle and blade pitch on the flow characteristics and energy cost. The pressure drop information obtained from the simulations was compared to several experimental correlations and data available in the literature. The numerical results were found in good agreement with the experimental values. From the obtained results, the twist technique is confirmed to be very useful to enhance the mixing with less power consumption and at low Reynolds numbers. A faster axial mixing has been achieved with increased blade length and decreased twist angle. However, the good mixing near the tube walls was obtained with increased twist angle. The power consumption expressed in power drop was found to be increase with increased CMC concentrations, Reynolds number, twist angle and decreased blade length

Towards the creation of a decision support system tool for the preliminary risk assessment of brownfield sites

Brownfield sites always raise concern for the health and safety of site workers involved in site renovations and developments and, subsequently, for the residents or occupants of the sites. As a minimum, a preliminary risk assessment is necessary to determine whether a brownfield site is contaminated and, if so, ensuring any redevelopment is safe and suitable for its proposed use. Despite growing interest in the progression of risk assessment tools, there are limited instruments available for brownfield site assessors to consult when conducting investigations at the preliminary risk assessment stage. This study presents a conceptual framework that ultimately aims to create a web-based decision support system (DSS) for the preliminary risk assessment of brownfield sites. This is based on a pollutant linkage model (Source–Pathway–Receptor). The proposed framework aids the identification of health and safety hazards and, in doing so, it addresses the challenges facing those persons dealing with the decision-making on brownfield site developments. Moreover, the framework enables them to determine the most appropriate remediation strategy(ies) to halt pollutant linkages, promote safer developments and minimise the risks to future occupants of brownfield sites and neighbouring lands

A systematic review of risk assessment tools for contaminated sites – Current perspectives and future prospects

© 2020 Elsevier Inc. Health and safety hazards associated with the redevelopment of contaminated sites can be complex and pose considerable risks. A systematic literature review was conducted on risk assessment tools for contaminated sites. These tools have been identified from searching through leading academic databases and other professional sources. For each of the identified tools the relevant risk assessment stages, harm type, hazard category, receptor type and pathways are reported. Findings reveal that despite growing interest in the development of risk assessment tools, there are persistent knowledge gaps identified in this study, which serve as a basis for future research direction to where more advanced practical tools could be invented. For instance, it is evidenced there is a shortfall in practical tools available to contaminated site assessors conducting investigations at the preliminary risk assessment stage. Addressing this opening can benefit the planning process, coordinated between relevant stakeholders and, moreover, reduce uncertainty in the decision-making of contaminated site developers

Role of imaging in rare COVID-19 vaccine multiorgan complications

As of September 18th, 2021, global casualties due to COVID-19 infections approach 200 million, several COVID-19 vaccines have been authorized to prevent COVID-19 infection and help mitigate the spread of the virus. Despite the vast majority having safely received vaccination against SARS-COV-2, the rare complications following COVID-19 vaccination have often been life-threatening or fatal. The mechanisms underlying (multi) organ complications are associated with COVID-19, either through direct viral damage or from host immune response (i.e., cytokine storm). The purpose of this manuscript is to review the role of imaging in identifying and elucidating multiorgan complications following SARS-COV-2 vaccination—making clear that, in any case, they represent a minute fraction of those in the general population who have been vaccinated. The authors are both staunch supporters of COVID-19 vaccination and vaccinated themselves as well

Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

Intérêt de l’acquisition précoce lors d’un examen TEP-PSMA marqué au gallium 68 dans le cadre du bilan de récidive biochimique d’un cancer de prostate

International audienc

Complete Response of a Patient With a Mismatch Repair Deficient Aggressive Pituitary Adenoma to Immune Checkpoint Inhibitor Therapy: A Case Report

BACKGROUND AND IMPORTANCE: Aggressive pituitary adenomas (APAs) are pituitary tumors that are refractory to standard treatments and carry a poor prognosis. Current treatment guidelines are not standardized but combine surgical resection, radiation therapy, and chemotherapy. Temozolomide is the only chemotherapeutic agent with documented effectiveness and is recommended for APA in European Society of Endocrinology clinical guidelines. CLINICAL PRESENTATION: A 57-year-old man presented with visual deterioration and bitemporal hemianopsia. MRI of the brain demonstrated a sellar mass suspected to be pituitary macroadenoma with displacement of the stalk and optic nerve impingement. The patient underwent stereotactic endoscopic transsphenoidal resection of the mass. Postoperative MRI demonstrated gross total resection. Pathology revealed a sparsely granulated corticotroph adenoma with malignant transformation. Immunohistochemistry showed loss of expression of MLH1 and PMS2 in the tumor cells. Proton therapy was recommended given an elevated Ki67 index and p53 positivity. Before radiotherapy, there was no radiographic evidence of residual tumor. Temozolomide therapy was initiated after surveillance MRI showed recurrence at 16 months postoperatively. However, MRI demonstrated marked progression after 3 cycles. Next-generation sequencing using the MSK-IMPACT platform identified somatic mutations in MLH1 Y548lfs*9 and TP53 R337C . Immunotherapy with ipilimumab/nivolumab was initiated, and MRI demonstrated no residual tumor burden 34 months postoperatively. CONCLUSION: APA is a tumor with frequent recurrence and a short median expected length of survival. Here, we demonstrate the utility of immunotherapy in a single case report of APA, with complete resolution of recurrent APA and improved survival compared with life expectancy