Some Factors of Methodism

Looks at the founding of Methodism and some of the characteristics that make the denomination unique

The Bible Mode of Baptism

https://place.asburyseminary.edu/ecommonsatsdigitalresources/1145/thumbnail.jp

A storm in a shelf sea: Variation in phosphorus distribution and organic matter stoichiometry

Organic matter (OM) plays an important role in productive shelf seas and their contribution to global carbon (C) and nutrient cycles. We investigated the impact of storm mixing on OM dynamics in the seasonally stratified Celtic Sea. After the storm, OM production was decoupled from consumption in the euphotic layer. Over the 15 day study, dissolved OM (DOM) became phosphorus (P) rich relative to C, whereas particulate OM (POM) became P-deplete relative to C. Upward diapycnal phosphate fluxes were accompanied by reciprocal downward mixing of dissolved organic P (DOP) and particulate P (PPhos). Transfer of DOP and PPhos below the thermocline accounts for 22% and 26%, respectively, of the upward phosphate flux. Given the changes in stoichiometry of POM and DOM after the storm, the form in which OM is transferred below the thermocline has important implications for the efficiency of elemental transfer, impacting C cycling and storage in the ocean

Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF.

IntroductionPatient-reported outcomes (PROs) and satisfaction endpoints are increasingly important in clinical trials and may be associated with treatment adherence. In this post hoc substudy from ROCKET AF, we examined whether patient-reported satisfaction was associated with study drug discontinuation.MethodsROCKET AF (n = 14,264) compared rivaroxaban with warfarin for prevention of stroke and systemic embolism in patients with atrial fibrillation. We analyzed treatment satisfaction scores: the Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM II). We compared satisfaction with study drug between the two treatment arms, and examined the association between satisfaction and patient-driven study drug discontinuation (stopping study drug due to withdrawal of consent, noncompliance, or loss to follow-up).ResultsA total of 1577 (11%) patients participated in the Patient Satisfaction substudy; 1181 (8.3%) completed both the ACTS and TSQM II 4 weeks after starting study drug. Patients receiving rivaroxaban did not experience significant differences in satisfaction compared with those receiving warfarin. During a median follow-up of 1.6 years, 448 premature study drug discontinuations occurred (213 rivaroxaban group; 235 warfarin group), of which 116 (26%) were patient-driven (52 [24%] rivaroxaban group; 64 [27%] warfarin group). No significant differences were observed between satisfaction level and rates of patient-driven study drug discontinuation.ConclusionsStudy drug satisfaction did not predict rate of study drug discontinuation. No significant difference was observed between satisfaction with warfarin and rivaroxaban, as expected given the double-blind trial design. Although these results are negative, the importance of PRO data will only increase, and these analyses may inform future studies that explore the relationship between drug-satisfaction PROs, adherence, and clinical outcomes. CLINICALTRIALS.GOV: NCT00403767.FundingThe ROCKET AF trial was funded by Johnson & Johnson and Bayer

Metal-rich organic matter and hot continental passive margin: drivers for Devonian copper-cobalt-germanium mineralization in dolomitized reef-bearing carbonate platform

The abundance and types of reef-bearing carbonate platforms reflect the evolution of Devonian climate, with conspicuous microbial-algal reefs in the warm Early and Late Devonian and sponge-coral reefs in the cooler Middle Devonian. A dolomitized Wenlock-Lower Devonian microbial-algal reef-bearing carbonate platform hosts epigenetic copper-cobalt-germanium (Cu-Co-Ge) sulfide mineralization at Ruby Creek-Bornite in the Brooks Range, Alaska. Here, we present rhenium-osmium (Re-Os) radiometric ages and molybdenum and sulfur (δ(98/95)Mo = +2.04 to +5.48‰ and δ(34)S = −28.5 to −1.8‰) isotope variations for individual Cu-Co-Fe sulfide phases along the paragenetic sequence carrollite-bornite-pyrite. In the context of a hot, extensional passive margin, greenhouse conditions in the Early Devonian favored restriction of platform-top seawater circulation and episodic reflux of oxidized brines during growth of the carbonaceous carbonate platform. Molybdenum and sulfur isotope data signal the stepwise reduction of hot brines carrying Cu during latent reflux and geothermal circulation for at least ca. 15 million years from the Early Devonian until Cu-Co sulfide mineralization ca. 379–378 million years ago (Ma) in the Frasnian, Late Devonian (weighted mean of Re-Os model ages of carrollite at 379 ± 15 Ma [n = 4]; Re-Os isochron age of bornite at 378 ± 15 Ma [n = 6]). On the basis of petrographic relationships between sulfides and solid bitumen, and the Mo and S isotope data for sulfides, we imply that the endowment in critical metals (e.g., Co, Ge, Re) in the Ruby Creek-Bornite deposit is linked to the activity of primary producers that removed trace metals from the warm Early Devonian seawater and concentrated Co, Ge, and Re in algal-bacterial organic matter in carbonate sediments. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00126-022-01123-1

Resource Availability and Entrainment Are Driven by Offsets Between Nutriclines and Winter Mixed‐Layer Depth

While phytoplankton play a key role in ocean biogeochemical cycles, the availability and supply pathways of resources that support their growth remain poorly constrained. Here, we show that the availability of various resources varies over several orders of magnitude throughout the Atlantic Ocean, causing regional contrasts in resource deficiency. Regional variations in the relative availability of nitrogen, phosphorous, silicon, iron, zinc, manganese, cobalt, and cadmium are important and result from the contrasts between winter mixing depths and differences in vertical profiles of the different resources. The winter-time thickening of the mixed layer may replenish or deplete resources via entrainment, depending on the vertical nutrient profile. For nutrients like nitrate, phosphate, and cadmium, entrainment is a consistent source term. While for others, such as manganese and iron, entrainment can reduce ocean resource availability, particularly in subtropical regions. Any future change to the depth of winter-time mixing will cause region-specific changes in relative availability of different resources that may have important ecological consequences