241 research outputs found
Bimaximal Mixings from the Texture of the Right-handed Majorana Neutrino Mass Matrix
We study the origin of neutrino masses and mixing angles which can accomodate
the LMA MSW solutions of the solar neutrino anomaly as well as the solution of
the atmospheric neutrino problem, within the framework of the see-saw
mechanism. We employ the diagonal form of the Dirac neutrino mass matrices with
the physical masses as diagonal elements in the hierarchical order. Such choice
has been motivated from the fact that the known CKM angles for the quark
sector, are relatively small. We consider both possibilities where the Dirac
neutrino mass matrix is either the charged lepton or the up-quark mass matrix
within the framework of SO(10) GUT with or without supersymmetry. The non-zero
texture of the right-handed Majorana neutrino mass matrix is used for
the generation of the desired bimaximal mixings in a model independent way.
Both hierarchical and inverted hierarchical models of the left-handed Majorana
neutrino mass matrices are generated and then discussed with examples
Numerical consistency check between two approaches to radiative corrections for neutrino masses and mixings
We briefly outline the two popular approaches on radiative corrections to
neutrino masses and mixing angles, and then carry out a detailed numerical
analysis for a consistency check between them in MSSM. We find that the two
approaches are nearly consistent with a small discrepancy of a factor of 13
percent in mass eigenvalues at low energy scale, but the predictions on mixing
angles are almost consistent. We check the stability of the three types of
neutrino models, i.e., hierarchical, inverted hierarchical and degenerate
models, under radiative corrections, using both approaches, and find consistent
conclusions. The neutrino mass models which are found to be stable under
radiative corrections in MSSM are the normal hierarchical model and the
inverted hierarchical model with opposite CP parity. We also carry out
numerical analysis on some important conjectures related to radiative
corrections in MSSM, viz., radiative magnification of solar and atmospheric
mixings in case of nearly degenerate model having same CP parity (MPR
conjecture) and radiative generation of solar mass scale in exactly two-fold
degenerate model with opposite CP parity and non-zero reactor angle (JM
conjecture). We observe certain exceptions to these conjectures. Finally the
effect of scale-dependent vacuum expectation value in neutrino mass
renormalisation is discussed.Comment: 26 pages, 5 figures,references added, typos corrected and text
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New Uncertainties in QCD-QED Rescaling Factors using Quadrature Method
In this paper we briefly outline the quadrature method for estimating
uncertainties in a function of several variables and apply it to estimate the
numerical uncertainties in QCD-QED rescaling factors. We employ here the
one-loop order in QED and three-loop order in QCD evolution equations of
fermion mass renormalization. Our present calculations are found to be new and
also reliable compared to the earlier values employed by various authors.Comment: 14 page
Разработка схемного решения планетарной передачи с промежуточными телами качения с полым валом в трансмиссии геохода
Use of an Anaerobic Chamber Environment for the Assay of Endogenous Cellular Protein-Tyrosine Phosphatase Activities
Protein-tyrosine phosphatases (PTPases) have a catalytic cysteine residue whose reduced state is integral to the reaction mechanism. Since exposure to air can artifactually oxidize this highly reactive thiol, PTPase assays have typically used potent reducing agents to reactivate the enzymes present; however, this approach does not allow for the measurement of the endogenous PTPase activity directly isolated from the in vivo cellular environment. Here we provide a method for using an anaerobic chamber to preserve the activity of the total PTPase complement in a tissue lysate or of an immunoprecipitated PTPase homolog to characterize their endogenous activation state. Comparison with a sample treated with biochemical reducing agents allows the determination of the activatable (reducible) fraction of the endogenous PTPase pool
Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation
BACKGROUNDCellular stressors influence the development of clonal hematopoiesis (CH). We hypothesized that environmental, inflammatory, and genotoxic stresses drive the emergence of CH in lung transplant recipients. METHODSWe performed a cross-sectional cohort study of 85 lung transplant recipients to characterize CH prevalence. We evaluated somatic variants using duplex error-corrected sequencing and germline variants using whole exome sequencing. We evaluated CH frequency and burden using χ2 and Poisson regression, and we evaluated associations with clinical and demographic variables and clinical outcomes using χ2, logistic regression, and Cox regression. RESULTSCH in DNA damage response (DDR) genes TP53, PPM1D, and ATM was increased in transplant recipients compared with a control group of older adults (28% versus 0%, adjusted OR [aOR], 12.9 [1.7-100.3], P = 0.0002). Age (OR, 1.13 [1.03-1.25], P = 0.014) and smoking history (OR 4.25 [1.02-17.82], P = 0.048) were associated with DDR CH. Germline variants predisposing to idiopathic pulmonary fibrosis were identified but not associated with CH. DDR CH was associated with increased cytomegalovirus viremia versus patients with no (OR, 7.23 [1.95-26.8], P = 0.018) or non-DDR CH (OR, 7.64 [1.77-32.89], P = 0.024) and mycophenolate discontinuation (aOR, 3.8 [1.3-12.9], P = 0.031). CONCLUSIONCH in DDR genes is prevalent in lung transplant recipients and is associated with posttransplant outcomes including cytomegalovirus activation and mycophenolate intolerance. FUNDINGNIH/NHLBI K01HL155231 (LKT), R25HL105400 (LKT), Foundation for Barnes-Jewish Hospital (LKT), Evans MDS Center at Washington University (KAO, MJW), ASH Scholar Award (KAO), NIH K12CA167540 (KAO), NIH P01AI116501 (AEG, DK), NIH R01HL094601 (AEG), and NIH P01CA101937 (DCL)
Atherosclerosis in Indigenous Tsimane: A Contemporary Perspective
The Horus and other research teams have found that atherosclerosis is not uncommon in ancient people through the study of their mummified remains (Murphy et al., 2003; Allam et al., 2009, 2011; Thompson et al., 2013, 2014). However, some have postulated that traditional hunter-gatherers are in some ways healthier than modern people and that they had very little atherosclerotic disease (O’Keefe et al., 2010). The aim of this study was to evaluate the burden of atherosclerosis in a population alive today but living a traditional lifestyle similar to that experienced by past populations. This led to the Tsimane Health and Life History Project Team (THLHP) (Gurven et al., 2017) and the Horus Study Team combining efforts to evaluate the prevalence and extent of coronary atherosclerosis in the Tsimane of Bolivia (Kaplan et al., 2017)
Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db Mice: Role of NADPH Oxidase 4
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Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study's infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi'omics Database ( http://ibdmdb.org ), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases
Discriminating neutrino mass models using Type II seesaw formula
In this paper we propose a kind of natural selection which can discriminate
the three possible neutrino mass models, namely the degenerate, inverted
hierarchical and normal hierarchical models, using the framework of Type II
seesaw formula. We arrive at a conclusion that the inverted hierarchical model
appears to be most favourable whereas the normal hierarchical model follows
next to it. The degenerate model is found to be most unfavourable. We use the
hypothesis that those neutrino mass models in which Type I seesaw term
dominates over the Type II left-handed Higgs triplet term are favoured to
survive in nature.Comment: No change in the results, a few references added, some changes in
Type[IIB] calculation
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