Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial

Introduction: Post-endodontic pain is one of the main problems for both patients and dentists. The purpose of this study was to compare the effectiveness of premedication with indomethacin and ibuprofen for management of postoperative endodontic pain. Methods and Materials: In this clinical trial, mandibular molars with irreversible pulpitis were endodontically treated in 66 patients. The medicines were prepared similarly in the form of capsules containing 400 mg ibuprofen (group A), 25 mg indomethacin (group B) and placebo (group C). The patients were given one capsule 1 h before the start of treatment. Patients recorded their pain measured by a visual analogue scale (VAS) at medication time, during treatment and 8, 12 and 24 h after treatment. The data were analyzed using the chi-square, repeated measures ANOVA, paired t-test, Tamhane and Pearson correlation coefficient. Results: Ibuprofen and indomethacin significantly reduced the postoperative pain in comparison with placebo during treatment and 8 h after treatment; however, there were no significant differences between them 12 and 24 h after treatment. Conclusion: Premedication with ibuprofen and indomethacin can effectively control short term post-operative pain; the lower incidence of side effects and greater analgesic power of ibuprofen make it a superior choice.Keywords: Ibuprofen; Indomethacin; Irreversible Pulpitis; Non-Steroidal Anti-Inflammatory Drugs; Post-Endodontic Pai

A comprehensive study on the stability analysis of vehicle dynamics with pure/combined-slip tyre models

This is an Accepted Manuscript of an article published by Taylor & Francis in Vehicle System Dynamics on September 28 2016, available online: http://dx.doi.org/10.1080/00423114.2016.1232417In this paper, a vehicle's lateral dynamic model is developed based on the pure and the combined-slip LuGre tyre models. Conventional vehicle's lateral dynamic methods derive handling models utilising linear tyres and pure-slip assumptions. The current article proposes a general lateral dynamic model, which takes the linear and nonlinear behaviours of the tyre into account using the pure and combined-slip assumptions separately. The developed methodology also incorporates various normal loads at each corner and provides a proper tyre–vehicle platform for control and estimation applications. Steady-state and transient LuGre models are also used in the model development and their responses are compared in different driving scenarios. Considering the fact that the vehicle dynamics is time-varying, the stability of the suggested time-varying model is investigated using an affine quadratic stability approach, and a novel approach to define the critical longitudinal speed is suggested and compared with that of conventional lateral stability methods. Simulations have been conducted and the results are used to validate the proposed method

Corner-based estimation of tire forces and vehicle velocities robust to road conditions

The final publication is available at Elsevier via https://doi.org/10.1016/j.conengprac.2017.01.009 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/Recent developments in vehicle stability control and active safety systems have led to an interest in reliable vehicle state estimation on various road conditions. This paper presents a novel method for tire force and velocity estimation at each corner to monitor tire capacities individually. This is entailed for more demanding advanced vehicle stability systems and especially in full autonomous driving in harsh maneuvers. By integrating the lumped LuGre tire model and the vehicle kinematics, it is shown that the proposed corner-based estimator does not require knowledge of the road friction and is robust to model uncertainties. The stability of the time-varying longitudinal and lateral velocity estimators is explored. The proposed method is experimentally validated in several maneuvers on different road surface frictions. The experimental results confirm the accuracy and robustness of the state estimators.Automotive Partnership Canada, Ontario Research Fund, General Motors Co

Resilient Corner-Based Vehicle Velocity Estimation

© 2017 IEEE. Pirani, M., Hashemi, E., Khajepour, A., Fidan, B., Kasaiezadeh, A., Chen, S.-K., & Litkouhi, B. (2017). Resilient Corner-Based Vehicle Velocity Estimation. IEEE Transactions on Control Systems Technology, 1–11. https://doi.org/10.1109/TCST.2017.2669157This paper presents longitudinal and lateral velocity estimators by considering the effect of the suspension compliance (SC) at each corner (tire) for ground vehicles. The estimators are developed to be resilient to sensor measurement inaccuracies, model and tire parameter uncertainties, switchings in observer gains, and measurement failures. More particularly, the stability of the observer is investigated, and its robustness to road condition uncertainties and sensor noises is analyzed. The sensitivity of the observers' stability and performance to the model parameter changes is discussed. Moreover, the stability of the velocity observers for two cases of arbitrary and stochastic switching gains is investigated. The stochastic stability of the observer in the presence of faulty measurements is also studied, and it is shown that if the probability of a faulty measurement occurring is less than a certain threshold, the observer error dynamics will remain stochastically stable. The performance of the observer and the effect of the SC are validated via several road experiments.Automotive Partnership Canada || Ontario Research Fund || General Motors Co. [grant numbers APCPJ 395996-09 and ORF-RE-04-039

Integrated estimation structure for the tire friction forces in ground vehicles

© IEEE 2017 Hashemi, E., Pirani, M., Khajepour, A., Fidan, B., Kasaiezadeh, A., Chen, S.-K., & Litkouhi, B. (2016). Integrated estimation structure for the tire friction forces in ground vehicles (pp. 1657–1662). IEEE. https://doi.org/10.1109/AIM.2016.7577008This paper presents a novel corner-based force estimation method to monitor tire capacities required for the traction and stability control systems. This is entailed for more advanced vehicle stability systems in harsh maneuvers. A novel estimation structure is proposed in this paper for the longitudinal, lateral, and vertical tire forces robust to the road friction condition. A nonlinear and a Kalman observer is utilized for estimation of the longitudinal and lateral friction forces. The stability and performance of the time-varying estimators are explored and it is shown that the developed integrated structure is robust to model uncertainties and does not require knowledge of the road friction. The proposed method is experimentally tested in several maneuvers on different road surface conditions and the results illustrate the accuracy and robustness of the state estimators.Automotive Partnership Canada, Ontario Research Fund, General Motors Co

Bifrontal Epidermoid Cyst

In this paper, we will present a case of a 63-year-old female with bifrontal epidermoid tumor who has gone under bilateral craniotomy. In a case report study, a 63-year-old female with a chief complaint of progressive headache that has been admitted to Department of Neurosurgery was studied. Magnetic resonance imaging was performed for better evaluation. After detection of bifrontal epidermoid cyst, the patient underwent surgery, and following the surgery, a cut of the tumor has been excised, sent for pathology sampling and reviewed for detection of cyst. Microscopic review of the resected part reported normal brain tissue along with sections containing parts of cyst wall covered by squamous epithelium and huge amount of irregularly stratified keratin within its lumen, which clearly emphasizes on diagnosis of a typical epidermoid tumor. Bifrontal epidermoid cyst is rare, and according to our study, the clinical symptoms and patients imaging were consistent with other studies

Empagliflozin in Patients with Chronic Kidney Disease

Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo