Sculpting Words in Ice: How Buddhist and Christian Stylistiques En-Act Mundane Failure and Ultimate Hope

Both Buddhist and Christian teaching-texts often deconstruct the “merely” mundane so that the learner can advance towards beatitude. A precious few of these texts teach by miming such a deconstruction via subtle literary techniques: the textual surfaces or conventions act-out the role of naï ve appearance, and the subtexts that subvert them act-out how confident trust (in the Buddha’s Teachings, for the Buddhists; in Christ’s Divine Prom- ises, for the Christians) can find fulfillment. In the great poem “The Altar” (by George Herbert, 1593-1633), the holistic appearance of the altar bears hidden signals of its own real brokenness, and these signals point to the sub-text that is the Christian’s hope. In the great Shobo-genzo of Dogen Zenji (1200-1253), formal techniques scramble conventional holisms and fixed identities in order to act-out the “true nature” of reality-reality, for Dogen, is at once “continuous flux” (and “absolute density”)

El trabajo como parte de la experiencia turística : El caso de ciudadanos argentinos que aplican al programa de vacaciones y trabajo en Australia

Desde sus inicios en 1975 hasta nuestros días, el programa de vacaciones y trabajo en Australia ha ganado gran popularidad en jóvenes de diversos países entre los que se encuentra Argentina. Esta modalidad de viajes encierra dos conceptos que han tenido una relación histórica de oposición como son el turismo y el trabajo. Sin embargo, como veremos en el presente estudio, existe un contexto actual que nos permite pensar que las fronteras de ambos campos no son impermeables y que podría ser posible su unión para formar parte de una experiencia turística. El objetivo general de la tesis es analizar si el trabajo puede ser considerado como parte de la experiencia turística teniendo en cuenta los programas de vacaciones y trabajo realizados por un grupo reducido de ciudadanos argentinos en Australia. Para cumplir con los objetivos de la investigación, se llevó a cabo una revisión de literatura sobre los diferentes temas que abordan el estudio y un trabajo de campo en el que se efectuaron entrevistas estructuradas a nueve participantes del programa y semiestructuradas a otros dos. Por último, a modo de complementar los testimonios recabados, también realizamos 51 cuestionarios a personas que llevaron a cabo dicho viaje.Facultad de Ciencias Económica

Adhesive root hairs facilitate Posidonia oceanica seedling settlement on rocky substrates

Posidonia oceanica, the dominant Mediterranean seagrass, has been historically described as a species typically growing on mobile substrates whose development requires precursor communities. During more than 10 years of direct observations, we noticed that P. oceanica seedlings were often firmly anchored to rocky reefs, even at exposed sites. Thus, we analysed the ultrastructural features of seedling root systems to identify specific traits that may represent adaptations for early seedling anchorage on rocky bottoms. Subapical sections of adventitious roots were obtained from 2-3 months old specimens collected in the field and were observed at SEM revealing an extensive coverage of adhesive root hairs with a maximum length of 2400 μm. Hairs were provided with an enlarged tips with a maximum width of 78.3 μm, which extended the contact area between the hair tip and the substrate. To test whether adhesive root hairs may facilitate P. oceanica seedlings establishment on rocky substrates, a manipulative experiment was performed. 360 seedlings were reared for 5 months in a land-based culture facility under simulated natural hydrodynamic conditions to identify suitable substrates for early seedling anchorage. Two main substrate features were investigated: firmness (i.e., sand vs. rock) and complexity (i.e., size of interstitial spaces between rocks). Anchorage was strongly influenced by substrate firmness and occurred only on rocks through adhesion by sticky root hairs. Percentage of anchored seedlings on rocks was as high as 89%. The minimum force required to dislodge plantlets attached to rocky substrates reached 23.8 N, which would potentially allow many plantlets to overcome winter storms in the field. The ability of rocky substrates to retain seedlings increased with their complexity. The interstitial spaces between rocks provided appropriate microsites for seedling settlement, as seeds were successfully retained and a suitable substrate for anchorage was available. Adhesive root hairs allowed fast and strong seedling anchorage to consolidated substrates when the root system was not yet developed. This mechanism could favour plant recruitment on rocky substrates with respect to mobile ones, in contrast with traditional paradigms. Such an adaptation leads to hypothesize a new microsite driven bottleneck in P. oceanica seedling survival linked to substrate features

Growth, body composition and hormonal status of growing pigs exhibiting a normal or small weight at birth and exposed to a neonatal diet enriched in proteins

Small birth weight and excess of early protein intake are suspected to enhance later obesity risk. The present study was undertaken to determine the impact of neonatal diets differing in protein content on growth, body composition and hormonal status of 70-d-old pigs born with normal weight (NW) or small weight (SW). At 7d of age, male and female suckled piglets were assigned to the NW (approximately 1·4kg at birth) or SW (approximately 0·99kg at birth) groups. They were fed milk replacers formulated to provide an adequate protein (AP) or a high protein (HP) supply for 3 weeks. From weaning to 70d of age, all animals received ad libitum the same standard diet. Growth rates were higher (P<0·05) in HP piglets than in AP piglets during formula feeding and remained higher (P<0·05) only in HP male pigs thereafter. No difference in feed consumption was detected between groups during the periods examined. Carcass lipid content and the relative weight of perirenal adipose tissue did not differ between the AP and HP pigs. Whereas plasma leptin concentration was higher (P<0·05) in HP pigs than in AP pigs with a marked difference in SW pigs, plasma insulin-like growth factor (IGF)-I concentration and expression of IGF system genes were not affected by the diets. In summary, a HP intake during the suckling period induced an increase in growth rate that persisted only in male pigs during the post-weaning period. This response was not associated with any difference in adiposity parameters in this perio

Comparison of two oral probiotic preparations in a randomized crossover trial highlights a potentially beneficial effect of Lactobacillus paracasei NCC2461 in patients with allergic rhinitis.

BACKGROUND: There is promising but conflicting evidence to recommend the addition of probiotics to foods for prevention and treatment of allergy. Based on previous studies with fermented milk containing Lactobacillus paracasei NCC2461, we aimed to compare the effect of a powder form of the latter probiotic with the effect of a blend of Lactobacillus acidophilus ATCC SD5221 and Bifidobacterium lactis ATCC SD5219 in patients with allergic rhinitis. METHODS: A double-blind, randomized, cross-over study, involving 31 adults with allergic rhinitis to grass pollen, was performed outside the grass pollen season (registration number: NCT01233154). Subjects received each product for 4-weeks in two phases separated by a wash-out period of 6 to 8 weeks. A nasal provocation test was performed before and after each 4-week product intake period, and outcome parameters (objective and subjective clinical symptoms; immune parameters) were measured during and/or 24 hours after the test. RESULTS: Out of the 31 subject enrolled, 28 completed the study. While no effect was observed on nasal congestion (primary outcome), treatment with NCC2461 significantly decreased nasal pruritus (determined by VAS), and leukocytes in nasal fluid samples, enhanced IL-5, IL-13 and IL-10 production by peripheral blood mononuclear cells in an allergen specific manner and tended to decrease IL-5 secretion in nasal fluid, in contrast to treatment with the blend of L. acidophilus and B. lactis. CONCLUSIONS: Despite short-term consumption, NCC2461 was able to reduce subjective nasal pruritus while not affecting nasal congestion in adults suffering from grass pollen allergic rhinitis. The associated decrease in nasal fluid leukocytes and IL-5 secretion, and the enhanced IL-10 secretion in an allergen specific manner may partly explain the decrease in nasal pruritus. However, somewhat unexpected systemic immune changes were also noted. These data support the study of NCC2461 consumption in a seasonal clinical trial to further demonstrate its potentially beneficial effect

Prolactin Receptor in Primary Hyperparathyroidism – Expression, Functionality and Clinical Correlations

<div><h3>Background</h3><p>Primary hyperparathyroidism (PHPT) is an endocrine disorder most commonly affecting women, suggesting a role for female hormones and/or their receptors in parathyroid adenomas. We here investigated the prolactin receptor (PRLr) which is associated with tumours of the breast and other organs.</p> <h3>Methodology/Principal Findings</h3><p>PRLr expression was investigated in a panel of 37 patients with sporadic parathyroid tumours and its functionality in cultured parathyroid tumour cells. In comparison with other tissues and breast cancer cells, high levels of prolactin receptor gene (<em>PRLR</em>) transcripts were demonstrated in parathyroid tissues. PRLr products of 60/70 kDa were highly expressed in all parathyroid tumours. In addition varying levels of the 80 kDa PRLr isoform, with known proliferative activity, were demonstrated. In parathyroid tumours, PRLr immunoreactivity was observed in the cytoplasm (in all cases, n = 36), cytoplasmic granulae (n = 16), the plasma membrane (n = 12) or enlarged lysosomes (n = 4). In normal parathyroid rim (n = 28), PRLr was uniformly expressed in the cytoplasm and granulae. In <em>in vitro</em> studies of short-term cultured human parathyroid tumour cells, prolactin stimulation was associated with significant transcriptional changes in JAK/STAT, RIG-I like receptor and type II interferon signalling pathways as documented by gene expression profiling. Moreover, <em>PRLR</em> gene expression in parathyroid tumours was inversely correlated with the patients’ plasma calcium levels.</p> <h3>Conclusions</h3><p>We demonstrate that the prolactin receptor is highly abundant in human parathyroid tissues and that PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours. Responsiveness of PRLr to physiological levels of prolactin was observed in the form of increased PTH secretion and altered gene transcription with significant increase of RIG-I like receptor, JAK-STAT and Type II interferon signalling pathways. These data suggest a role of the prolactin receptor in parathyroid adenomas.</p> </div