Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Elliptic flow of charged particles at midrapidity relative to the spectator plane in Pb–Pb and Xe–Xe collisions

Measurements of the elliptic flow coefficient relative to the collision plane defined by the spectator neutrons v2{ SP} in collisions of Pb ions at center-of-mass energy per nucleon–nucleon pair √ 2.76 TeV and Xe ions at √ sNN = sNN =5.44 TeV are reported. The results are presented for charged particles produced at midrapidity as a function of centrality and transverse momentum for the 5–70% and 0.2–6 GeV/c ranges, respectively. The ratio between v2{ SP} and the elliptic flow coefficient relative to the participant plane v2{4}, estimated using four-particle correlations, deviates by up to 20% from unity depending on centrality. This observation differs strongly from the magnitude of the corresponding eccentricity ratios predicted by the TRENTo and the elliptic power models of initial state fluctuations that are tuned to describe the participant plane anisotropies. The differences can be interpreted as a decorrelation of the neutron spectator plane and the reaction plane because of fragmentation of the remnants from the colliding nuclei, which points to an incompleteness of current models describing the initial state fluctuations. A significant transverse momentum dependence of the ratio v2{ SP}/v2{4} is observed in all but the most central collisions, which may help to understand whether momentum anisotropies at low and intermediate transverse momentum have a common origin in initial state f luctuations. The ratios of v2{ SP} and v2{4} to the corresponding initial state eccentricities for Xe–Xe and Pb–Pb collisions at similar initial entropy density show a difference of (7.0 ±0.9)%with an additional variation of +1.8% when including RHIC data in the TRENTo parameter extraction. These observations provide new experimental constraints for viscous effects in the hydrodynamic modeling of the expanding quark–gluon plasma produced in heavy-ion collisions at the LHC

First measurement of Ωc0 production in pp collisions at s=13 TeV

The inclusive production of the charm–strange baryon 0 c is measured for the first time via its hadronic √ decay into −π+ at midrapidity (|y| <0.5) in proton–proton (pp) collisions at the centre-of-mass energy s =13 TeV with the ALICE detector at the LHC. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 2 < pT < 12 GeV/c. The pT dependence of the 0 c-baryon production relative to the prompt D0-meson and to the prompt 0 c-baryon production is compared to various models that take different hadronisation mechanisms into consideration. In the measured pT interval, the ratio of the pT-integrated cross sections of 0 c and prompt + c baryons multiplied by the −π+ branching ratio is found to be larger by a factor of about 20 with a significance of about 4σ when compared to e+e− collisions

Necessidades de treinamento organizacional e motivação para trabalhar Training needs and work motivation: analysis of the relationship

Apesar de contribuir com a programação, a execução e a avaliação de resultados, a etapa de análise de necessidades tem sido constantemente negligenciada pela literatura científica e pela prática profissional de treinamento, cujos volumosos investimentos, portanto, tendem a ser desperdiçados. Os modelos que orientam este importante campo foram propostos há aproximadamente 50 anos, de forma que não são capazes, atualmente, de orientar teórica e metodologicamente estudiosos e praticantes da área. Nesse sentido, esta pesquisa objetivou, mediante execução de análise de covariância em amostra de 213 participantes, investigar a relação entre motivação para o trabalho e complexidade de necessidades de treinamento, com vistas a permitir a composição futura de modelos teóricos de análise de necessidades integrados, não apenas por componentes relacionados às tarefas, como prescrito na literatura, mas, também, por variáveis relativas aos níveis individual, grupal e organizacional de análise. Especificamente, quatro objetivos específicos, cada qual associado a procedimentos e técnicas de pesquisa particulares, foram determinados: (1) elaborar, por meio de pesquisa documental e grupo de foco, e validar, teórica e empiricamente, a partir de entrevista individual e realização de análises fatoriais exploratórias, instrumento para aferição das necessidades de treinamento; (2) adaptar e validar estatisticamente o instrumento de medida de motivação para trabalhar, também em função de análises fatoriais exploratórias; (3) com teste de diferença de médias entre amostras independentes, formar grupos de comparação em função do no nível de motivação para trabalhar dos respondentes; e (4) identificar variáveis de controle estatístico para composição do modelo final de investigação a partir de correlações bivariadas. Os resultados obtidos satisfizeram todos esses quatro objetivos intermediários de pesquisa: bons índices psicométricos de validação e confiabilidade dos instrumentos de necessidades e de motivação foram obtidos; dois grupos de comparação puderam ser estatisticamente formados em função dos níveis de motivação de seus integrantes; e o tempo de serviço pôde ser selecionado como variável de controle estatístico para a composição do modelo final de investigação. Apesar desses resultados positivos, a análise de covariância efetuada não evidenciou relação alguma entre motivação e necessidades de treinamento, contrariando parte da literatura, não diretamente relacionada à área de treinamento, que atesta esta relação direta. Este resultado torna necessária a ampliação e o aprofundamento de pesquisas nesse sentido, principalmente pelo fato de a motivação ser uma das principais variáveis individuais responsáveis pela explicação de medidas de desempenho pós-treinamento.<br>Although contributing to the planning, execution and results evaluation, the needs analysis subsystem has been consistently neglected by the training scientific literature and professional practice, whose bulky investments, therefore, tend to be wasted. The models that guide this important field have been proposed about 50 years ago, so they are not capable, today, of theoretical and methodological guide scholars and practitioners in the area. Thus, this study aimed, through implementation of analysis of covariance in a sample of 213 participants, to investigate the relationship between motivation to work and complexity of training needs, in order to allow the composition of future needs analysis theoretical models integrated not only for components related to the tasks, as prescribed in the literature, but also by variables related to the individual, group and organizational level of analysis. Specifically, four specific objectives, each one associated with particular procedures and research techniques were determined: (1) developing, through documental research and focus group, and validate, theoretically and empirically, from individual interviews and exploratory factor analysis, instrument for measuring training needs; (2) adapt and statistically validate the instrument to measure motivation to work, also through of exploratory factor analysis; (3) to test for mean differences between independent samples produce comparison groups depending on the level of respondents' motivation to work; and (4) identifying control variables for statistical composition of the final research, from bivariate correlations. The results satisfied all of these four intermediate goals: good psychometric indices of reliability and validity of the instruments of needs and motivation were obtained; two groups could be statistically formed according to level of motivation of its members; and the time service might be selected as a control variable for the statistical composition of the final investigation model. Despite these positive results, the covariance analysis performed did not show any relation between motivation and training needs, contrary to conventional wisdom, not directly related to the training area, which certifies this direct relationship. This result makes it necessary to expand and deepen research in this direction, mainly because the motivation is one of the main individual variables responsible for the explanation of post-performance training measures