The investigation of flame spreading over the surface of igniting solid propellants Final summary report

Flame spreading over surface of igniting solid propellants in different gas mixtures at various pressure

Adhesive coating eliminated in new honeycomb-core fabrication process

Technique eliminates use of silicone-based adhesive material as bonding medium. Adhesive requires precise time-temperature cure. Prepreg resin is used as bonding medium, and each layer is laminated together to form honeycomb billet. Process can be used in any application where nonmetallic honeycomb core is being fabricated

Detecting the signatures of helium in type Iax supernovae

Recent studies have argued that the progenitor system of type Iax supernovae must consist of a carbon-oxygen white dwarf accreting from a helium star companion. Based on existing explosion models invoking the pure deflagration of carbon-oxygen white dwarfs, we investigate the likelihood of producing spectral features due to helium in type Iax supernovae. From this scenario, we select those explosion models producing ejecta and $^{56}$Ni masses that are broadly consistent with those estimated for type Iax supernovae (0.014 - 0.478~$M_{\odot}$ and $\sim0.003$ - 0.183~$M_{\odot}$, respectively). To this end, we present a series of models of varying luminosities ($-18.4 \lesssim M_{\rm{V}} \lesssim -14.5$~mag) with helium abundances accounting for up to $\sim$36\% of the ejecta mass, and covering a range of epochs beginning a few days before B$-$band maximum to approximately two weeks after maximum. We find that the best opportunity for detecting \ion{He}{i} features is at near-infrared wavelengths, and in the post-maximum spectra of the fainter members of this class. We show that the optical spectrum of SN~2007J is potentially consistent with a large helium content (a few 10$^{-2}~M_{\odot}$), but argue that current models of accretion and material stripping from a companion struggle to produce compatible scenarios. We also investigate the presence of helium in all objects with near-infrared spectra. We show that SNe~2005hk, 2012Z, and 2015H contain either no helium or their helium abundances are constrained to much lower values ($\lesssim$10$^{-3}~M_{\odot}$). Our results demonstrate the differences in helium content among type Iax supernovae, perhaps pointing to different progenitor channels. Either SN~2007J is an outlier in terms of its progenitor system, or it is not a true member of the type Iax supernova class.Comment: 15 pages, 12 figures, 2 tables. Accepted for publication in Astronomy and Astrophysic

Flame Spreading over the Surface of Double Base Propellants at High Pressure Annual Report

Flame spreading over igniting surface of double base propellants in high pressure quiescent environmen

Fluent temporal logic for discrete-time event-based models

Fluent model checking is an automated technique for verifying that an event-based operational model satisfies some state-based declarative properties. The link between the event-based and state-based formalisms is defined through fluents which are state predicates whose value are determined by the occurrences of initiating and terminating events that make the fluents values become true or false, respectively. The existing fluent temporal logic is convenient for reasoning about untimed event-based models but difficult to use for timed models. The paper extends fluent temporal logic with temporal operators for modelling timed properties of discrete-time event-based models. It presents two approaches that differ on whether the properties model the system state after the occurrence of each event or at a fixed time rate. Model checking of timed properties is made possible by translating them into the existing untimed framework. Copyright 2005 ACM

Helical structures from an isotropic homopolymer model

We present Monte Carlo simulation results for square-well homopolymers at a series of bond lengths. Although the model contains only isotropic pairwise interactions, under appropriate conditions this system shows spontaneous chiral symmetry breaking, where the chain exists in either a left- or a right-handed helical structure. We investigate how this behavior depends upon the ratio between bond length and monomer radius.Comment: 10 pages, 3 figures, accepted for publication by Physical Review Letter

Modelling the early time behaviour of type Ia supernovae: effects of the 56Ni distribution

Recent studies have demonstrated the diversity in type Ia supernovae (SNe Ia) at early times and highlighted a need for a better understanding of the explosion physics as manifested by observations soon after explosion. To this end, we present a Monte Carlo code designed to model the light curves of radioactively driven, hydrogen-free transients from explosion to approximately maximum light. In this initial study, we have used a parametrised description of the ejecta in SNe Ia, and performed a parameter study of the effects of the $^{56}$Ni distribution on the observed colours and light curves for a fixed $^{56}$Ni mass of 0.6 $M_\odot$. For a given density profile, we find that models with $^{56}$Ni extending throughout the entirety of the ejecta are typically brighter and bluer shortly after explosion. Additionally, the shape of the density profile itself also plays an important role in determining the shape, rise time, and colours of observed light curves. We find that the multi-band light curves of at least one SNe Ia (SN 2009ig) are inconsistent with less extended $^{56}$Ni distributions, but show good agreement with models that incorporate $^{56}$Ni throughout the entire ejecta. We further demonstrate that comparisons with full $UVOIR$ colour light curves are powerful tools in discriminating various $^{56}$Ni distributions, and hence explosion models.Comment: 14 pages, 8 figures, 2 tables. Minor changes in notation to match published version in Astronomy & Astrophysic

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.

One major hurdle to the success of adoptive T-cell therapy is the identification of antigens that permit effective targeting of tumors in the absence of toxicities to essential organs. Previous work has demonstrated that T cells engineered to express chimeric antigen receptors (CAR-T cells) targeting the murine homolog of the colorectal cancer antigen GUCY2C treat established colorectal cancer metastases, without toxicity to the normal GUCY2C-expressing intestinal epithelium, reflecting structural compartmentalization of endogenous GUCY2C to apical membranes comprising the intestinal lumen. Here, we examined the utility of a human-specific, GUCY2C-directed single-chain variable fragment as the basis for a CAR construct targeting human GUCY2C-expressing metastases. Human GUCY2C-targeted murine CAR-T cells promoted antigen-dependent T-cell activation quantified by activation marker upregulation, cytokine production, and killing of GUCY2C-expressing, but not GUCY2C-deficient, cancer cells in vitro. GUCY2C CAR-T cells provided long-term protection against lung metastases of murine colorectal cancer cells engineered to express human GUCY2C in a syngeneic mouse model. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C, providing durable survival in a human xenograft model in immunodeficient mice. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer

Shear History Extensional Rheology Experiment: A Proposed ISS Experiment

The Shear History Extensional Rheology Experiment (SHERE) is a proposed International Space Station (ISS) glovebox experiment designed to study the effect of preshear on the transient evolution of the microstructure and viscoelastic tensile stresses for monodisperse dilute polymer solutions. Collectively referred to as Boger fluids, these polymer solutions have become a popular choice for rheological studies of non-Newtonian fluids and are the non-Newtonian fluid used in this experiment. The SHERE hardware consists of the Rheometer, Camera Arm, Interface Box, Cabling, Keyboard, Tool Box, Fluid Modules, and Stowage Tray. Each component will be described in detail in this paper. In the area of space exploration, the development of in-situ fabrication and repair technology represents a critical element in evolution of autonomous exploration capability. SHERE has the capability to provide data for engineering design tools needed for polymer parts manufacturing systems to ensure their rheological properties have not been impacted in the variable gravity environment and this will be briefly addressed