229 research outputs found
Interactions and Disorder in Quantum Dots: Instabilities and Phase Transitions
Using a fermionic renormalization group approach we analyse a model where the
electrons diffusing on a quantum dot interact via Fermi-liquid interactions.
Describing the single-particle states by Random Matrix Theory, we find that
interactions can induce phase transitions (or crossovers for finite systems) to
regimes where fluctuations and collective effects dominate at low energies.
Implications for experiments and numerical work on quantum dots are discussed.Comment: 4 pages, 1 figure; version to appear in Phys Rev Letter
Quantum chaos in nanoelectromechanical systems
We present a theoretical study of the electron-phonon coupling in suspended
nanoelectromechanical systems (NEMS) and investigate the resulting quantum
chaotic behavior. The phonons are associated with the vibrational modes of a
suspended rectangular dielectric plate, with free or clamped boundary
conditions, whereas the electrons are confined to a large quantum dot (QD) on
the plate's surface. The deformation potential and piezoelectric interactions
are considered. By performing standard energy-level statistics we demonstrate
that the spectral fluctuations exhibit the same distributions as those of the
Gaussian Orthogonal Ensemble (GOE) or the Gaussian Unitary Ensemble (GUE),
therefore evidencing the emergence of quantum chaos. That is verified for a
large range of material and geometry parameters. In particular, the GUE
statistics occurs only in the case of a circular QD. It represents an anomalous
phenomenon, previously reported for just a small number of systems, since the
problem is time-reversal invariant. The obtained results are explained through
a detailed analysis of the Hamiltonian matrix structure.Comment: 14 pages, two column
Quantum Dots with Disorder and Interactions: A Solvable Large-g Limit
We show that problem of interacting electrons in a quantum dot with chaotic
boundary conditions is solvable in the large-g limit, where g is the
dimensionless conductance of the dot. The critical point of the
theory (whose location and exponent are known exactly) that separates strong
and weak-coupling phases also controls a wider fan-shaped region in the
coupling-1/g plane, just as a quantum critical point controls the fan in at
T>0. The weak-coupling phase is governed by the Universal Hamiltonian and the
strong-coupling phase is a disordered version of the Pomeranchuk transition in
a clean Fermi liquid. Predictions are made in the various regimes for the
Coulomb Blockade peak spacing distributions and Fock-space delocalization
(reflected in the quasiparticle width and ground state wavefunction).Comment: 4 pages, 2 figure
A coarsened multinomial regression model for perinatal mother to child transmission of HIV
Background: In trials designed to estimate rates of perinatal mother to child transmission of HIV, HIV assays are scheduled at multiple points in time. Still, infection status for some infants at some
time points may be unknown, particularly when interim analyses are conducted.
Methods: Logistic regression models are commonly used to estimate covariate-adjusted transmission rates, but their methods for handling missing data may be inadequate. Here we propose using coarsened multinomial regression models to estimate cumulative and conditional
rates of HIV transmission. Through simulation, we compare the proposed models to standard logistic models in terms of bias, mean squared error, coverage probability, and power. We consider a range of treatment effect and visit process scenarios, while including imperfect sensitivity of the assay and contamination of the endpoint due to early breastfeeding transmission. We illustrate the approach through analysis of data from a clinical trial designed to prevent perinatal transmission.
Results: The proposed cumulative and conditional models performed well when compared to their logistic counterparts. Performance of the proposed cumulative model was particularly strong under scenarios where treatment was assumed to increase the risk of in utero transmission but decrease the risk of intrapartum and overall perinatal transmission and under scenarios designed
to represent interim analyses. Power to estimate intrapartum and perinatal transmission was consistently higher for the proposed models.
Conclusion: Coarsened multinomial regression models are preferred to standard logistic models for estimation of perinatal mother to child transmission of HIV, particularly when assays are missing
or occur off-schedule for some infants.U.S. National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and Dept. of Health and Human Services (DHHS)
Spin and e-e interactions in quantum dots: Leading order corrections to universality and temperature effects
We study the statistics of the spacing between Coulomb blockade conductance
peaks in quantum dots with large dimensionless conductance g. Our starting
point is the ``universal Hamiltonian''--valid in the g->oo limit--which
includes the charging energy, the single-electron energies (described by random
matrix theory), and the average exchange interaction. We then calculate the
magnitude of the most relevant finite g corrections, namely, the effect of
surface charge, the ``gate'' effect, and the fluctuation of the residual e-e
interaction. The resulting zero-temperature peak spacing distribution has
corrections of order Delta/sqrt(g). For typical values of the e-e interaction
(r_s ~ 1) and simple geometries, theory does indeed predict an asymmetric
distribution with a significant even/odd effect. The width of the distribution
is of order 0.3 Delta, and its dominant feature is a large peak for the odd
case, reminiscent of the delta-function in the g->oo limit. We consider finite
temperature effects next. Only after their inclusion is good agreement with the
experimental results obtained. Even relatively low temperature causes large
modifications in the peak spacing distribution: (a) its peak is dominated by
the even distribution at kT ~ 0.3 Delta (at lower T a double peak appears); (b)
it becomes more symmetric; (c) the even/odd effect is considerably weaker; (d)
the delta-function is completely washed-out; and (e) fluctuation of the
coupling to the leads becomes relevant. Experiments aimed at observing the T=0
peak spacing distribution should therefore be done at kT<0.1 Delta for typical
values of the e-e interaction.Comment: 15 pages, 4 figure
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
METHODS: The European Society of Intensive Care Medicine invited 12 experts to form a Task Force to update a previous consensus (Antonelli et al.: Intensive Care Med 33:575-590, 2007). The same five questions addressed in the earlier consensus were used as the outline for the literature search and review, with the aim of the Task Force to produce statements based on the available literature and evidence. These questions were: (1) What are the epidemiologic and pathophysiologic features of shock in the intensive care unit ? (2) Should we monitor preload and fluid responsiveness in shock ? (3) How and when should we monitor stroke volume or cardiac output in shock ? (4) What markers of the regional and microcirculation can be monitored, and how can cellular function be assessed in shock ? (5) What is the evidence for using hemodynamic monitoring to direct therapy in shock ? Four types of statements were used: definition, recommendation, best practice and statement of fact.
RESULTS: Forty-four statements were made. The main new statements include: (1) statements on individualizing blood pressure targets; (2) statements on the assessment and prediction of fluid responsiveness; (3) statements on the use of echocardiography and hemodynamic monitoring.
CONCLUSIONS: This consensus provides 44 statements that can be used at the bedside to diagnose, treat and monitor patients with shock
Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever
We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination
The Diaphragm and Lubricant Gel for Prevention of Cervical Sexually Transmitted Infections: Results of a Randomized Controlled Trial
BACKGROUND: We evaluated the effectiveness of the Ortho All-Flex Diaphragm, lubricant gel (Replens) and condoms compared to condoms alone on the incidence of chlamydial and gonococcal infections in an open-label randomized controlled trial among women at risk of HIV/STI infections. METHODS: We randomized 5045 sexually-active women at three sites in Southern Africa. Participants who tested positive for curable STIs were treated prior to enrollment as per local guidelines. Women were followed quarterly and tested for Chlamydia trachomatis (CT) or Neisseria gonorrhoeae (GC) infection by nucleic-acid amplification testing (Roche Amplicor) using first-catch urine specimens. STIs detected at follow-up visits were treated. We compared the incidence of first infection after randomization between study arms in both intent-to-treat (ITT) and per-protocol populations. FINDINGS: Baseline demographic, behavioral and clinical characteristics were balanced across study arms. Nearly 80% of participants were under 35 years of age. Median follow-up time was 21 months and the retention rate was over 93%. There were 471 first chlamydia infections, 247 in the intervention arm and 224 in the control arm with an overall incidence of 6.2/100 woman-years (wy) (relative hazard (RH) 1.11, 95% Confidence Interval (CI): 0.93-1.33; p = 0.25) and 192 first gonococcal infections, 95 in the intervention arm and 97 in the control arm with an overall incidence of 2.4/100wy (RH 0.98, 95%CI: 0.74-1.30; p = 0.90). Per protocol results indicated that when diaphragm adherence was defined as "always use" since the last visit, there was a significant reduction in the incidence of GC infection among women randomized to the intervention arm (RH 0.61, 95%CI: 0.41-0.91, P = 0.02). INTERPRETATION: There was no difference by study arm in the rate of acquisition of CT or GC. However, our per-protocol results suggest that consistent use of the diaphragm may reduce acquisition of GC. TRIAL REGISTRATION: ClinicalTrials.gov NCT00121459
Survival associated pathway identification with group Lp penalized global AUC maximization
It has been demonstrated that genes in a cell do not act independently. They interact with one another to complete certain biological processes or to implement certain molecular functions. How to incorporate biological pathways or functional groups into the model and identify survival associated gene pathways is still a challenging problem. In this paper, we propose a novel iterative gradient based method for survival analysis with group Lp penalized global AUC summary maximization. Unlike LASSO, Lp (p < 1) (with its special implementation entitled adaptive LASSO) is asymptotic unbiased and has oracle properties [1]. We first extend Lp for individual gene identification to group Lp penalty for pathway selection, and then develop a novel iterative gradient algorithm for penalized global AUC summary maximization (IGGAUCS). This method incorporates the genetic pathways into global AUC summary maximization and identifies survival associated pathways instead of individual genes. The tuning parameters are determined using 10-fold cross validation with training data only. The prediction performance is evaluated using test data. We apply the proposed method to survival outcome analysis with gene expression profile and identify multiple pathways simultaneously. Experimental results with simulation and gene expression data demonstrate that the proposed procedures can be used for identifying important biological pathways that are related to survival phenotype and for building a parsimonious model for predicting the survival times
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