Etiology of Breast Development and Asymmetry

Etiology of breast development and asymmetry is a fascinating research topic physiologically as well as pathophysiology from a certain condition. The shape, contour, and size of the breast are unique to each female. These factors are influenced by genetics, weight, exercise, menstruation cycles, pregnancy, menopause status, and age. An attempt was made to research the breast development at fetal development and transitioning into adulthood and menopause. Additionally, we compare breast development in males to the developments in females. Although breast asymmetry is experienced by all women, it ranges from grossly undetectable to the need for surgical intervention. It is thought that breast asymmetry has intrinsic and extrinsic factors that determine the type and the extent of asymmetry observed. Hormones at play and their effect on breast asymmetry throughout breast development has been charted. Breast asymmetry is most often secondary to benign breast disorders and unassociated with a risk for malignancy. As the perception of one’s body image is an integral part of self-confidence, breast asymmetry has the potential to affect every woman’s quality of life, regardless of the degree of asymmetry. Throughout this effort, our aim was to analyze and understand breast development in males and females, breast changes from the prepubertal to post-menopausal period, benign pathological changes, summarizing the etiologies of breast asymmetry, and their effects on quality of life

Appraisal of Chicken Production with Associated Biosecurity Practices in Commercial Poultry Farms Located in Jos, Nigeria

A questionnaire-based study of chicken production system with on-farm biosecurity practices was carried out in commercial poultry farms located in Jos, Nigeria. Commercial and semicommercial farms had 75.3% and 24.5% of 95,393 birds on 80 farms, respectively. Farms using deep litter and battery cage systems were 69 (86.3%) and 10 (12.5%), respectively. In our biosecurity scoring system, a correct practice of each indicator of an event scored 1.00 and biosecurity score (BS) of each farm was the average of the scores of biosecurity indicators for the farm, giving BS of zero and 1.00 as absence of biosecurity and optimal biosecurity, respectively. Semicommercial farms had higher BS than commercial farms. The flock size did not significantly ( > 0.05) affect the mean BS. Disease outbreaks correlated ( = −0.97) with BS, showing a tendency of reduction of disease outbreaks with increasing BS. Outbreaks were significantly ( < 0.05) associated with deep litter system. In conclusion, the chicken production system requires increased drive for excellent biosecurity practices and weak points in the biosecurity could be ameliorated by extension of information to farmers in order to support expansion of chicken production with robust biosecurity measures that drastically reduce risk of disease outbreak

Awareness and Acceptance of Harm Reduction Services in a Nigerian Psychiatric Hospital: Patients’ and Family Caregivers’ Perspective

Introduction: There are burgeoning data on harm reduction services (HRSs) as a viable alternative to the traditional means of dealing with substance abuse in the developed countries. Despite the numerous benefits, its awareness and acceptability in developing economies such as Nigeria have been constrained by sociocultural and political factors. However, the specific patients’ and caregivers’ barriers to its uptake have not been evaluated in Nigeria. Aim: This study aimed to examine the awareness and acceptability of HRS among patients and caregivers in Enugu, South‑Eastern Nigeria. Materials and Methods: This study was a descriptive survey of patients with substance use disorders and their family caregivers at Enugu. Awareness and acceptance of HRS were assessed using questions adapted from the harm reduction survey. Results: The majority of patients and caregivers (76.5% and 88.2%, respectively) were not aware of HRS.  Compared to family caregivers, the patients were more likely to rate themselves more favourably disposed to accepting HRS (U = 2750.00, p < 0.001). The common reasons given for accepting HRS among the patients were centered on autonomy and the unrealistic nature of abstinence. The reasons for  rejection by family caregivers were hinged on encouraging use, community resistance, and scandals to the family. Conclusion: This study highlighted the low awareness of both patients and their caregivers to the availability of HRS as a treatment option in Nigeria. It is hoped that these findings will provide some invaluable data to policy makers and clinicians in designing policies and in public education to improve service utilization by the public

Splenotoxic effect of radiographic developer effluent on Wistar rats

Background: Histological changes associated with toxicity of radiographic developer effluents on spleen tissues have not been previously studied. The present study therefore aimed at demonstrating the histopathological changes in splenic tissues of Wistar rats following exposure to developer effluent.Methods: Eighteen young Wistar rats weighing 140-220g were used for the study. The animals were divided randomly into three groups of 6 rats each based on the dose of developer effluent administered to them – i.e. control group I (0 dose) and experimental groups II (lower dose, 200 mg/kg) and III (higher dose, 400 mg/kg) respectively. The groups were further classified as either A or B sub-groups of three rats each, depending on the duration (14 or 28 days) of effluent administration. The effluent administration was done by oral gavages.Results: Normal spleen histology was observed in the control group. In contrast, tissue degeneration and necrosis; lymphocytic infiltration as well as reduction of splenic follicles were observed in some of the test groups (IIA, IIB and IIIA). Interestingly, the toxic effects of the developer effluent on group IIIB administered with higher dose for a longer period of 28 days were not as severe as observed in the other test groups.Conclusions: The present study which indicated adverse effects of exposures to sub-lethal doses of developer effluent on Wistar rats’ spleen tissues suggests the need for proper management and disposal of radiographic effluents.

Tax-financing of Budget Deficits in LDCs: Re-validation of Laffer Curve Theory

Urgent need for quick action to put Nigeria and other developing economies back to the path of economic recovery has almost imposed state of emergency on these economies. Most LDCs are faced with acute shortage of development funds due to recessions accompanying incessant crashes in international financial market. Raising existing tax rates to finance budget deficit in LDCs often generates public debate on pros and cons of such policy option. Study considered Nigeria as typical case of LDCs. Study focused on establishing the effectiveness of tax-financing of budget deficit under Laffer curve theory. Study spanned across 1970-2015. Data were analyzed using ADF, CUSUM, heteroskedasticity, multiple regression, Johansen cointegration and ECM. Results indicate that: (1) Custom and exercise duties, petroleum profit tax and value-added tax contributed significantly to the reduction in budget deficit while company income tax had nonsignificant impact(2)Total government revenue constituted major chunk of planned income for budget deficit financing(3) Deficit financing of capital health expenditure yielded high returns while that of recurrent education expenditure and capital education expenditure was accompanied by low returns (4)Growth and employment generation accelerated deficit financing while private investment decelerated it (5) There were long and short-run relationships among budget deficit, taxes, human capital investment and macroeconomic indicators with significant rate of adjustment of short-run disequilibrium. Study concluded that tax-financing of budget deficit was effective under Laffer curve effect. It was recommended, among others, that LDCs should enlarge their tax bases through inclusion, to finance budget deficit

Tax-budget Deficit Relationships: Fiscalists’ Platform for Deficit Financing Policy

With heavy debt burden on developing economies accompanied by their low credit worthiness rating, developing economies often resort to taxes for financing development projects. Raising tax rates and expanding tax bases have become frequent government activities in developing economies. Without dynamic deficit financing policy which takes into cognizance the conflicting arithmetic and economic effect of Laffer curve analysis, financing budget deficit through taxation has remained largely unsuccessful. Perhaps, what was required is to constitute latent factors operating along Laffer curve into major theoretical construct of a deficit financing policy. Therefore, study focused on identifying latent factors influencing the inter-relationship among budget deficit finance, taxes, human capital and macroeconomic indicators. Study spanned across 1970-2015. Data were sourced from Central Bank of Nigeria, National Bureau of Statistics and World Development Indicators. Data were analyzed using exploratory factor analysis. Results indicate that: (1) Tax contributed significantly to budget deficit financing (2)Tax spending and disposable personal income were latent factors influencing the effectiveness of deficit financing (3) Tax spending activated government revenue to contribute significantly to budget deficit reduction (4) Disposable personal income boosted GDP to cause reduction in budget deficit . It was concluded that, with the taxonomy of highly significant factor correlates of tax spending and disposable personal income, a viable deficit financing policy was devised with component tax, budgetary, pricing, credit and macroeconomic policies. It was recommended, inter alia, that developing economies should activate their current deficit financing policies by adapting them to their tax spend and macroeconomic policies

Haematological Changes in Patients with Lymphoid Malignancies on Chemotherapy in Benin City, Edo State, Nigeria

Chemotherapy continues to serve as the best option therapy in treating human malignancies that have undergone metastasis and cannot be managed solely by surgical removal or radiation. The aim of this study is to evaluate the clinical important of haematological parameters in the management of lymphoid malignancy patients on chemotherapy to ascertain the impact of such chemotherapy on them.. This study was carried out in one secondary and one tertiary health institution in Edo State. It was divided into three groups: lymphoid malignancy on chemotherapy, novel lymphoid malignancy and apparently healthy individuals as controls. Using aseptic precaution, 5ml of blood is collected into K2EDTA container for full blood count analysis using KX-21NSysmex automated Haematology analyser 2004 model and data were analysed using student t test. The comparison between novel lymphoid malignant patient and controls indicate WBC, lymphocytes and platelet count increase significantly (P <0.05) while RBC, HGB, HCT decrease significantly (P <0.05) when compared with control. However, MCV, MCH, MCHC, monocytes and granulocytes were not significant (P>0.05). The comparison  between lymphoid malignant patient on chemotherapy and controls shows RBC, HGB, HCT decrease significantly when compared with control (P <0.05) while WBC, lymphocytes, platelet, MCV, MCH, MCHC, monocytes and granulocytes were not significant (P>0.05).When lymphoid malignant patient on chemotherapy and novel lymphoid malignant patient are compared, it shows RBC, HGB, HCT increase significantly when compared with novel lymphoid malignant patients (P <0.05) while WBC and MCHC decrease significantly (P <0.05). However, lymphocytes, platelet, MCV, MCH, monocytes and granulocytes were not significant (P>0.05). we can deduce that full blood count is highly clinically important for an effective management of lymphoid malignant patients on chemotherapy. DOI: 10.7176/JMPB/61-04 Publication date: November 30th 201

In Support of the Matrix Language Frame Model: Evidence from Igbo-English Intrasentential Codeswitching

This paper explores the morphosyntactic features of mixed nominal expressions in a sample of empirical Igbo-English intrasentential codeswitching data (i.e. codeswitching within a bilingual clause) in terms of the Matrix Language Frame (MLF) model. Since both Igbo and English differ in the relative order of head and complement within the nominal argument phrase, the analysed data seem appropriate for testing the veracity of the principal assumption underpinning the MLF model: the notion that the two languages (in our case Igbo and English) participating in codeswitching do not both contribute equally to the morphosyntactic frame of a mixed constituent. As it turns out, the findings provide both empirical and quantitative support for the basic theoretical view that there is a Matrix Language (ML) versus Embedded Language (EL) hierarchy in classic codeswitching as predicted by the MLF model because both Igbo and English do not simultaneously satisfy the roles of the ML in Igbo-English codeswitching

Detection of Haemoparasites of Blood Donors in 9 Locations in and Around Plateau State, Nigeria

Haemoparasites in the tropics are also endemic in Nigeria. Asymptomatic infections may abound, due to resistance to these infections. This asymptomatic infection has been one of the factors, which has maintained transmission of these pathogens, through many ways, including blood donation and transfusion. In this report, haemoparasitic infections in blood donors have been described, from blood donors within Plateau State, Nigeria. Five hundred and twelve blood donors were selected by means of a random sampling method and their blood samples collected. Serological assay was done using rapid test kits to check for presence of antibodies (in the case of microfilariae) or antigens (in the case of malaria) to the different haemoparasites. Also, Elisa technique was used for the microfilariae. Thick and thin films were made from each blood sample on grease-free slides allowed to dry and stained by 3% Giemsa solution for 45 min which is the Giemsa technique. Results indicate that 270 (52.7%) of the sample population had no infection; 121( 23.6%) of the population were infected with Plasmodium falciparum; 11 (2.1%) were infected with Plasmodium malariae; 69 (13.5%) were infected with HBsAg; 29 (5.7%) were infected with HCV; 7 ( I.4% ) were infected with Trypanosoma brucei gambiense; 1% were infected with microfilariae, 4( 0.8% ) of the 1% were unsheathed and identified to be Mansonella perstans, while 1(0.2%) were sheathed and identified to be Loa loa. Most blood group types were susceptible to haemoparasitic infections. The result of the study therefore stresses the need to screen blood for haemoparasites before transfusion, owing to the dangers of doing otherwise. The occupations and dwelling places of the donors are predisposing factors to these haemoparasitic infections. Since they have the passion to save lives through blood donation, they should therefore make the necessary adjustments that will make them more suitable lifesavers. It is recommended that the basic transmission factors of these parasites are explained to donors to reduce further incidences. DOI: 10.7176/JBAH/9-22-01 Publication date: November 30th 201

MIDA boronates are hydrolysed fast and slow by two different mechanisms

MIDA boronates (N-methylimidodiacetic boronic acid esters) serve as an increasingly general platform for small-molecule construction based on building blocks, largely because of the dramatic and general rate differences with which they are hydrolysed under various basic conditions. Yet the mechanistic underpinnings of these rate differences have remained unclear, which has hindered efforts to address the current limitations of this chemistry. Here we show that there are two distinct mechanisms for this hydrolysis: one is base mediated and the other neutral. The former can proceed more than three orders of magnitude faster than the latter, and involves a rate-limiting attack by a hydroxide at a MIDA carbonyl carbon. The alternative 'neutral' hydrolysis does not require an exogenous acid or base and involves rate-limiting B-N bond cleavage by a small water cluster, (H2O)n. The two mechanisms can operate in parallel, and their relative rates are readily quantified by (18)O incorporation. Whether hydrolysis is 'fast' or 'slow' is dictated by the pH, the water activity and the mass-transfer rates between phases. These findings stand to enable, in a rational way, an even more effective and widespread utilization of MIDA boronates in synthesis