Obliquity measurement and atmospheric characterization of the WASP-74 planetary system

We present new transit observations of the hot Jupiter WASP-74 b ($T_\mathrm{eq} \sim$ 1860 K) using the high-resolution spectrograph HARPS-N and the multi-colour simultaneous imager MuSCAT2. We refine the orbital properties of the planet and its host star, and measure its obliquity for the first time. The measured sky-projected angle between the stellar spin-axis and the planet's orbital axis is compatible with an orbit well-aligned with the equator of the host star ($\lambda = 0.77\pm0.99 \mathrm{deg}$). We are not able to detect any absorption feature of H$\alpha$, or any other atomic spectral features, in its high-resolution transmission spectra due to low S/N at the line cores. Despite previous claims regarding the presence of strong optical absorbers such TiO and VO gases in the atmosphere of WASP-74 b, the new ground-based photometry combined with a reanalysis of previously reported observations from the literature shows a slope in the low-resolution transmission spectrum steeper than expected from Rayleigh scattering alone.Comment: Accepted for publication in Astronomy & Astrophysics. 12 pages, 8 figures, 5 table

A hot sub-Neptune in the desert and a temperate super-Earth around faint M dwarfs: Color validation of TOI-4479b and TOI-2081b

We report the discovery and validation of two TESS exoplanets orbiting faint M dwarfs: TOI-4479b and TOI-2081b. We have jointly analyzed space (TESS mission) and ground based (MuSCAT2, MuSCAT3 and SINISTRO instruments) lightcurves using our multi-color photometry transit analysis pipeline. This allowed us to compute contamination limits for both candidates and validate them as planet-sized companions. We found TOI-4479b to be a sub-Neptune-sized planet ($R_{p}=2.82^{+0.65}_{-0.63}~\rm R_{\oplus}$) and TOI-2081b to be a super-Earth-sized planet ($R_{p}=2.04^{+0.50}_{-0.54}~\rm R_{\oplus}$). Furthermore, we obtained that TOI-4479b, with a short orbital period of $1.15890^{+0.00002}_{-0.00001}~\rm days$, lies within the Neptune desert and is in fact the largest nearly ultra-short period planet around an M dwarf known to date. These results make TOI-4479b rare among the currently known exoplanet population around M dwarf stars, and an especially interesting target for spectroscopic follow-up and future studies of planet formation and evolution.Comment: Accepted for publication in Astronomy&Astrophysic

TOI-2285b: A 1.7 Earth-radius planet near the habitable zone around a nearby M dwarf

We report the discovery of TO1-2285b, a sub-Neptune-sized planet transiting a nearby (42 pc) M dwarf with a period of 27.3 d. We identified the transit signal from the Transiting Exoplanet Survey Satellite photometric data, which we confirmed with ground-based photometric observations using the multiband imagers MuSCAT2 and MuSCAT3. Combining these data with other follow-up observations including high-resolution spectroscopy with the Tillinghast Reflector Echelle Spectrograph, high-resolution imaging with the SPeckle Polarimeter, and radial velocity (RV) measurements with the InfraRed Doppler instrument, we find that the planet has a radius of 1.74 +/- 0.08 R-circle plus, a mass of <19.5 M-circle plus + (95% c.I.), and an insolation flux of 1.54 +/- 0.14 times that of the Earth. Although the planet resides just outside the habitable zone for a rocky planet, if the planet harbors an H2O layer under a hydrogen-rich atmosphere, then liquid water could exist on the surface of the H2O layer depending on the planetary mass and water mass fraction. The bright host star in the near-infrared (K-s = 9.0) makes this planet an excellent target for further RV and atmospheric observations to improve our understanding of the composition, formation, and habitability of sub-Neptune-sized planets

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

The CARMENES search for exoplanets around M dwarfs: Two planets on opposite sides of the radius gap transiting the nearby M dwarf LTT 3780

We present the discovery and characterisation of two transiting planets observed by the Transiting Exoplanet Survey Satellite (TESS) orbiting the nearby (d∗ ≈ 22 pc), bright (J ≈ 9 mag) M3.5 dwarf LTT 3780 (TOI-732). We confirm both planets and their association with LTT 3780 via ground-based photometry and determine their masses using precise radial velocities measured with the CARMENES spectrograph. Precise stellar parameters determined from CARMENES high-resolution spectra confirm that LTT 3780 is a mid-M dwarf with an effective temperature of Teff = 3360 ± 51 K, a surface gravity of log g∗ = 4.81 ± 0.04 (cgs), and an iron abundance of [Fe/H] = 0.09 ± 0.16 dex, with an inferred mass of M∗ = 0.379 ± 0.016M· and a radius of R∗ = 0.382 ± 0.012R·. The ultra-short-period planet LTT 3780 b (Pb = 0.77 d) with a radius of 1.35-0.06+0.06 R·, a mass of 2.34-0.23+0.24 M·, and a bulk density of 5.24-0.81+0.94 g cm-3 joins the population of Earth-size planets with rocky, terrestrial composition. The outer planet, LTT 3780 c, with an orbital period of 12.25 d, radius of 2.42-0.10+0.10 R·, mass of 6.29-0.61+0.63 M·, and mean density of 2.45-0.37+0.44 g cm-3 belongs to the population of dense sub-Neptunes. With the two planets located on opposite sides of the radius gap, this planetary system is anexcellent target for testing planetary formation, evolution, and atmospheric models. In particular, LTT 3780 c is an ideal object for atmospheric studies with the James Webb Space Telescope (JWST)

Introducing the LBT Imaging of Galactic Halos and Tidal Structures (LIGHTS) survey: A preview of the low surface brightness Universe to be unveiled by LSST

We present the first results of the LBT Imaging of Galaxy Haloes and Tidal Structures (LIGHTS) survey. LIGHTS is an ongoing observational campaign with the 2 × 8.4 m Large Binocular Telescope (LBT) aiming to explore the stellar haloes and the low surface brightness population of satellites down to a depth of μV ∼31 mag arcsec-2 (3σ in 10″ × 10″ boxes) of nearby galaxies. We simultaneously collected deep imaging in the g and r Sloan filters using the Large Binocular Cameras. The resulting images are 60 times (i.e. ∼4.5 mag) deeper than those from the Sloan Digital Sky Survey, and they have characteristics comparable (in depth and spatial resolution) to the ones expected from the future Legacy Survey of Space and Time (LSST). Here we show the first results of our pilot programme targeting NGC 1042 (an M 33 analogue at a distance of 13.5 Mpc) and its surroundings. The depth of the images allowed us to detect an asymmetric stellar halo in the outskirts of this galaxy whose mass (1.4 ± 0.4 × 108 M) is in agreement with the ΛCDM expectations. Additionally, we show that deep imaging from the LBT reveals low mass satellites (a few times 105 M) with very faint central surface brightness μV(0) ∼27 mag arcsec-2 (i.e. similar to Local Group dwarf spheroidals, such as Andromeda XIV or Sextans, but at distances well beyond the local volume). The depth and spatial resolution provided by the LIGHTS survey open up a unique opportunity to explore the 'missing satellites' problem in a large variety of galaxies beyond our Local Group down to masses where the difference between the theory and observation (if any) should be significant

Exploring the link between MORF4L1 and risk of breast cancer

Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. Methods: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. Results: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to g-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively. Conclusions: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers

Exploring the link between MORF4L1 and risk of breast cancer

Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. Methods: Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. Results: A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to g-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively. Conclusions: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers