418 research outputs found

    Hepcidin and iron status in chronic kidney disease

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    Hepcidin is a critical inhibitor of iron export frommacrophages, enterocytes, and hepatocytes. Given that itis filtered and degraded by the kidney, its elevated levelsin renal failure have been suggested to play a role in thedisordered iron metabolism of uremia. It is a smalldefensin-like peptide whose production by hepatocytes ismodulated in response to anemia, hypoxia, orinflammation. Hepcidin could also act as an indicator offunctional iron deficiency (FID) in chronic kidneydisease (CKD) patients. This study was performed toassess hepcidin and its correlations with renal function,iron status parameters {serum iron, serum ferritin,transferrin saturation (TSAT) and soluble transferrinreceptor (sTfR)}, inflammatory cytokines (IL-6&IFN-?)and inflammatory markers (CRP) in patients with CKDeither on conservative treatment or on maintenancehemodialysis (HD). Serum prohepcidin was higher inHD patients compared to controls and CKD patients. Inthe whole patient group, serum hepcidin correlatedsignificantly with hemoglobin (Hb), IL-6, creatinine,CRP, sTfR and urinary hepcidin. In HD groupprohepcidin correlated significantly with creatinine.Multiple regression analysis showed that prohepcidinwas most predicted by serum creatinine and CRP.Elevated prohepcidin levels in HD patients studied couldmainly be due to its accumulation in impaired renalfunction in addition to low-grade inflammation,frequently encountered in this population

    The role of three different contrast-enhanced, abbreviated MRI protocols as a screening tool of hepatocellular carcinoma in patients with chronic hepatitis C virus infection

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    Purpose: Our study aims to assess the role and diagnostic performance of 3 different contrast-enhanced, abbreviated magnetic resonance imaging (MRI) protocols as a screening tool of hepatocellular carcinoma (HCC). Material and methods: Our retrospective study included 80 patients who were screened for HCC: 47 patients revealed 138 focal hepatic lesions. MRI examinations were performed including full CE-MRI protocols. The MRI was done on a 1.5 T machine. Then 3 different abbreviated contrast-enhanced MRI protocols were analysed separately. The standard dynamic contrast MRI and abbreviated protocols were evaluated following the LI-RADS 2018 lexicon diagnostic features. Results: A considerable overall kappa (k) agreement between the abbreviated 1, 2, and 3 protocols on LI-RADS classification was noted with k = 0.865. There was almost perfect agreement between all abbreviated protocols and full standard protocol on LI-RADS classification, with k = 0.890. As regards the k agreement on LI-RADS classification, there was a considerable highest agreement between the abbreviated 1 protocol and the full standard protocol, with k = 0.980. The abbreviated 1 and 2 protocols showed high diagnostic performance on LI-RADS classification of lesions, with 100% sensitivity, specificity, PPV, NPV, and accuracy, while the abbreviated 3 protocol showed a lesser but comparable sensitivity 96.9%, NPV 99.4, and accuracy 99.4%. Conclusions: Abbreviated contrast-enhanced MRI protocols can be used as a screening tool for the detection of HCC, with high sensitivity, specificity, PPV, NPV, and accuracy close to the full protocol. There was a considerable highest agreement between the abbreviated 1 protocol and the full standard protocol. Subsequently, this protocol can be used as a standard protocol for screening high-risk patients

    Automatic Face and Hijab Segmentation Using Convolutional Network

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    Taking pictures and Selfies are now very common and frequent between people. People are also interested in enhancing pictures using different image processing techniques and sharing them on social media. Accurate image segmentation plays an important role in portrait editing, face beautification, human identification, hairstyle identification, airport Surveillance system and many other computer vision problems. One specific functionality of interest is automatic face and veil segmentation as this allows processing each separately. Manual segmentation can be difficult and annoying especially on smartphones small screen. In this paper, the proposed model uses fully convolutional network (FCN) to make semantic segmentation into skin, veil and background. The proposed model achieved an outperforming result on the dataset which consists of 250 images with global accuracy 92% and mean accuracy 92.69

    Public realm for enhanced quality of Life :Interactive spaces combating climate change

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    Currently, facing climate change stands as a crucial focus within architecture, urban planning and design .Urban design is constructive endeavor aimed at benefiting the public. The public realm that creates the environment for individuals and communities to effectively, safely, meaningfully and permanently lead their lives .For a prolonged duration the public realm have been formulated to accommodate severe climatic conditions .the reality persists that the essence of a signification public realm continue to be widely disregarded . The aim is to clarify how exceptional quality, effectively designed, and well-managed approaches can be beneficial to implement as a strategy for climate change adaptation and environmental resilience as well as rising the standard of quality of life. based on the literatures analysis .both empirical and theoretical studies as well as developing the concepts of adaptive reorganization of the existing public spaces using landscape design ,in an effort to improve the quality of life and to tackle climate change . As a result, the paper concludes that the focus on integrating elements of urban planning and design for public realm ,as well as the aesthetic and visual quality ,demonstrates how adaptation to climate change can become a catalyst for change .by transforming challenges into resources and creating value, it plays a significant role in enhancing the quality of open spaces . Additionally, an increase in interaction with the space was observed, including motivation for engaging in activities and a sense of happines

    Using recycled materials towards sustainable, eco-friendly building in hot regions – A Review

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    Due to population growth and increased urban activity, there is a rise in waste production, which poses health and environmental risks. Additionally, the extraction and transportation of natural resources to places of employment require significant energy consumption, and the world has therefore moved to seek new alternatives away from traditional construction methods by recycling building materials such as concrete, brick, glass, wood, etc., or using new building materials such as rice straw, plastics, corks, etc., taking into account architectural design. The research is aimed at demonstrating that recycled materials have the potential to perform a better environmental performance by preserving the environment and the natural resources used to produce construction materials and providing energy of all kinds, as well as reducing costs

    Assessment of natural radionuclides and heavy metal concentrations in marine sediments in view of tourism activities in Hurghada city, northern Red Sea, Egypt

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    The specific activity of 40K, 232Th and 226Ra in marine sediment samples collected from National Institute of Oceanography and Fisheries (NIOF) and Safier Hotel area in Hurghada city (the most important regions in Egypt), were measured by gamma ray spectrometry using NaI(Tl) detector. The values of specific activity varied from 7 ± 1 Bq kg-1 to 53 ± 4 Bq kg-1, 6 ± 1 Bq kg-1 to 32 ± 6 Bq kg-1, and from 167 ± 11 Bq kg-1 to 1120 ± 63 Bq kg-1 for 226Ra, 232Th and 40K, respectively. The heavy metals have been measured and analysed by atomic absorption spectrometer. The major range values of heavy metals concentrations in marine sediment samples were: Cu (10.5-78.0 μg g-1), Zn (21-150 μg g-1), Pb (30-53 μg g-1), Cd (2.50-4.00 μg g-1), Fe (5100-13150 μg g-1), Mn (118-298 μg g-1), Ni (17-36 μg g-1) and Co (16-18 μg g-1). The total organic matter (TOC) and carbonates (CaCo3) distribution have been measured at some locations. Also, the frequency distribution and the value of (232Th/226Ra), (232Th/40K) and (226Ra/40K) ratio for all measured samples were determined. Additionally, evaluations have been made of the radiological hazards and the results are diagrammed by Surfer program in maps. © Penerbit Universiti Sains Malaysia, 2019

    Stellar Image Interpretation System using Artificial Neural Networks: Unipolar Function Case

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    An artificial neural network based system for interpreting astronomical images has been developed. The system is based on feed-forward Artificial Neural Networks (ANNs) with error back-propagation learning. Knowledge about images of stars, cosmic ray events and noise found in images is used to prepare two sets of input patterns to train and test our approach. The system has been developed and implemented to scan astronomical digital images in order to segregate stellar images from other entities. It has been coded in C language for users of personal computers. An astronomical image of a star cluster from other objects is undertaken as a test case. The obtained results are found to be in very good agreement with those derived from the DAOPHOTII package, which is widely used in the astronomical community. It is proved that our system is simpler, much faster and more reliable. Moreover, no prior knowledge, or initial data from the frame to be analysed is required
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