On Binary Codes from Conics in PG(2,q)

Let A be the incidence matrix of passant lines and internal points with respect to a conic in PG(2, q), where q is an odd prime power. In this article, we study both geometric and algebraic properties of the column null space L of A over the finite field of 2 elements. In particular, using methods from both finite geometry and modular presentation theory, we manage to compute the dimension of L, which provides a proof for the conjecture on the dimension of the binary code generated by L

Global well-posedness for the Gross-Pitaevskii equation with an angular momentum rotational term

In this paper, we establish the global well-posedness of the Cauchy problem for the Gross-Pitaevskii equation with an rotational angular momentum term in the space \Real^2.Comment: 10 page

EGFRvIII and Pten Deletion Mutations Influence Genotype-Dependent Kinome Activation in Immortalized Murine Astrocyte Models of Glioblastoma

Glioblastoma (GBM) is the most common malignant primary brain tumor. Receptor tyrosine kinase (RTK) pathways are frequently mutated in GBM, including alterations in the RTK Epidermal Growth Factor Receptor (EGFR). Moreover, EGFR variant III (EGFRvIII) is the most common activating mutation in GBM. Given its frequency, specificity, and role in promoting gliomagenesis, EGFR dysfunction is a prime target for drug treatment. However, multiple resistance mechanisms, such as co-occurrence of EGFRvIII and deletion of the tumor suppressor PTEN, prevent effective treatment via activation of alternate kinase pathways. To observe the differential kinase activation involved in EGFRvIII- and PTEN loss- driven gliomagenesis and identify potential kinase targets for dual therapy, we examined immortalized murine astrocytes derived from non-germline genetically engineered mouse models expressing four core genotypes: wild-type EGFR + wild-type Pten (C), wild-type EGFR + Pten deletion (CP), EGFRvIII + wild-type Pten (CEv3), and EGFRvIII + Pten deletion (CEv3P). We used RNA sequencing and multiplexed inhibitor bead affinity chromatography and mass spectrometry (MIB-MS) to determine the baseline transcriptomes and kinomes of each genotype. We determined that cell lines exhibited genotype-dependent baseline RNA expression and kinase activity as a result of EGFRvIII and/or Pten deletion relative to C astrocytes and across genotypes. We observed several differentially-activated kinases that represent potential targets for dual treatment with EGFR TKI. We are currently examining changes in the kinome profile of each cell line after both acute and chronic treatment with tyrosine kinase inhibitors (TKI). These results will help define the kinase networks involved in tumor development and resistance and may aid in the identification of potential personalized combination therapy with EGFR TKI for GBM patients.Bachelor of Scienc

March 2, 1989

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia

March 22, 1982

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia

Cell model of DJ-1-associated Parkinson’s Disease

Indiana University-Purdue University Indianapolis (IUPUI)Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic in nature, however 10% - 15% of patients show a positive family history of the disease. While many genes have been found to be implicated in the familial form of PD, early-onset autosomal recessive PD has been associated with mutations in PARK7, a gene which codes for the protein DJ-1. While there are many proposed roles of DJ-1 across numerous systems, the function of DJ-1 in relation to the development and progression of PD remains largely unclear. A first step towards determining this function is the creation of biologically relevant cell models of PD. The goal of this work was to design a representative cell model of DJ-1-associated PD in order to further study DJ-1 with the intention of elucidating its relevant function in relation of PD pathogenesis

March 1, 1982

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia

February 3, 1983

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia