ASSOCIATION BETWEEN MICROALBUMINURIA AND OXIDATIVE STRESS IN DIABETIC NEPHROPATHY

Objectives: Diabetic Nephropathy (DN) is a leading cause of chronic kidney disease and end stage renal failure worldwide. This study aimed to evaluate the association between oxidants, antioxidants and microalbuminuria in Diabetic Nephropathy compared with Type II Diabetes Mellitus (DM). Methods: The study includes 60 Type II Diabetes Mellitus and 40 Diabetic Nephropathy Patients. Parameters performed HbA1c, urea, creatinine, total proteins, microalbuminuria, glutathione peroxidase and malondialdehyde(MDA). Results: The levels of HbA1c, urea, creatinine, microalbuminuria and malondialdehyde are significantly higher in DN compared with Type II DM. the levels of T.P and glutathione peroxidase are decreased in DN compared with Type II DM. Conclusion: Low levels of glutathione peroxidase and total proteins were observed in DN. HbA1c, urea, creatinine, microalbuminuria and malondialdehyde levels were elevated in DN compared with Type II DM.KEYWORDS: Diabetic Nephropathy; Glutathione peroxidase; Microalbuminuria; Malondialdehyde

ASSOCIATION BETWEEN MICROALBUMINURIA AND OXIDATIVE STRESS IN DIABETIC NEPHROPATHY

Objectives: Diabetic Nephropathy (DN) is a leading cause of chronic kidney disease and end stage renal failure worldwide. This study aimed to evaluate the association between oxidants, antioxidants and microalbuminuria in Diabetic Nephropathy compared with Type II Diabetes Mellitus (DM). Methods: The study includes 60 Type II Diabetes Mellitus and 40 Diabetic Nephropathy Patients. Parameters performed HbA1c, urea, creatinine, total proteins, microalbuminuria, glutathione peroxidase and malondialdehyde(MDA). Results: The levels of HbA1c, urea, creatinine, microalbuminuria and malondialdehyde are significantly higher in DN compared with Type II DM. the levels of T.P and glutathione peroxidase are decreased in DN compared with Type II DM. Conclusion: Low levels of glutathione peroxidase and total proteins were observed in DN. HbA1c, urea, creatinine, microalbuminuria and malondialdehyde levels were elevated in DN compared with Type II DM.KEYWORDS: Diabetic Nephropathy; Glutathione peroxidase; Microalbuminuria; Malondialdehyde

The pituitary tumor transforming gene 1 (PTTG-1): An immunological target for multiple myeloma

<p>Abstract</p> <p>Background</p> <p>Multiple Myeloma is a cancer of B plasma cells, which produce non-specific antibodies and proliferate uncontrolled. Due to the potential relapse and non-specificity of current treatments, immunotherapy promises to be more specific and may induce long-term immunity in patients. The pituitary tumor transforming gene 1 (PTTG-1) has been shown to be a novel oncogene, expressed in the testis, thymus, colon, lung and placenta (undetectable in most other tissues). Furthermore, it is over expressed in many tumors such as the pituitary adenoma, breast, gastrointestinal cancers, leukemia, lymphoma, and lung cancer and it seems to be associated with tumorigenesis, angiogenesis and cancer progression. The purpose was to investigate the presence/rate of expression of PTTG-1 in multiple myeloma patients.</p> <p>Methods</p> <p>We analyzed the PTTG-1 expression at the transcriptional and the protein level, by PCR, immunocytochemical methods, Dot-blot and ELISA performed on patient's sera in 19 multiple myeloma patients, 6 different multiple myeloma cell lines and in normal human tissue.</p> <p>Results</p> <p>We did not find PTTG-1 presence in the normal human tissue panel, but PTTG-1 mRNA was detectable in 12 of the 19 patients, giving evidence of a 63% rate of expression (data confirmed by ELISA). Four of the 6 investigated cell lines (66.6%) were positive for PTTG-1. Investigations of protein expression gave evidence of 26.3% cytoplasmic expression and 16% surface expression in the plasma cells of multiple myeloma patients. Protein presence was also confirmed by Dot-blot in both cell lines and patients.</p> <p>Conclusion</p> <p>We established PTTG-1's presence at both the transcriptional and protein levels. These data suggest that PTTG-1 is aberrantly expressed in multiple myeloma plasma cells, is highly immunogenic and is a suitable target for immunotherapy of multiple myeloma.</p

The Role of Syd Phosphorylation in Syd Interaction with the Retrograde Motor Complex, Dynein-Dynactin

From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Volume 1, Spring 2009. Published by the Office of Undergraduate Research. Henry Biggs, Director, Office of Undergraduate Research and Associate Dean, College of Arts & Sciences; E. Holly Tasker, Editor. Mentor: Valeria Cavall

The Role of Syd Phosphorylation in Syd Interaction with the Retrograde Motor Dynein-dynactin

Mentor: Valeria Cavalli From the Washington University Undergraduate Research Digest: WUURD, Volume 5, Issue 1, Fall 2009. Published by the Office of Undergraduate Research. Henry Biggs, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Joy Zalis Kiefer, Undergraduate Research Coordinator, Co-editor, and Assistant Dean in the College of Arts & Sciences; Kristin Sobotka, Editor

Intelligent Agribusiness System-An Echo Friendly IOT based Approach

Internet of Things (IoT) innovation is one of the fastest growing fields in various regions or aspects which include irrigation. IoT works on the character of our lives by way of bringing and cultivating modifications in many fields of exercises to motive them to come to be convenient, savvy and enriched with the aid of adequate guy-made recognition. As a result of this innovation, smart cultivating frameworks recognize a social trade towards current agri-business that is more useful, consumes less water, and is extraordinarily less luxurious. The primary goal of this paper is to make use of IoT within the agribusiness subject to accumulate facts right away (soil Moister, temperature), with a purpose to help one with staring at a few climate situations distantly, effectively and improve massively the creation and thus the pay of ranchers. The modern version is created utilizing NodeMCU innovation, which contains express sensors, and a Wifi module that assists with amassing moment records on the internet. It is worth concentrating on the testing of this model created, profoundly precise data in light of the fact that any herbal changes were outstanding in a flash and taking into consideration to decide. This paper speculating about integrating the IoT with different other technologies

Neurocognitive Mechanisms of Anti-Lingual & Accent Bias Stereotyping in Virtual Reality and the Sustainable Development of Linguistic Response

Raising awareness through Virtual Experiencing (RAVE) and a Cross-Cultural Perspective on Raising Awareness through Virtual Experiencing (C-RAVE) approaches are used in this article to promote awareness of concerns relating to linguistic stereotyping. Virtual Reality (VR) technology has completely changed several facets of modern life, including instruction, training and entertainment. We give a summary of the techniques employed to increase awareness of how stereotypes might distort our vision. The patterns of the answers provided by the participants demonstrate that the reported gender of the speaker in addition to the accent (native vs. non-native), has an impact on the respondents' assessments of performance. Additionally, we were able to show that the discussions and ideas produced by these response patterns led to a rise in self-awareness of language and stereotyping-related problems. The paper gives a general description of RAVE and examines how it may improve education, create empathy and foster good social change. Focus on a critique of our methodologies and place our work within a larger debate of strategies and efforts for how educational institutions might actively contribute to combating (language) discrimination and bias in many ways. The relevance of Raising Awareness by Virtual Reality and Cross-Cultural Raising of Awareness by Virtual Reality in fostering inclusion and understanding in a society that is becoming more sustainable globally connected is highlighted in the article’s conclusion