Popularitas Empat Destinasi Wisata Pulau Terbaik Dunia Menggunakan Google Trends

Tujuan: Penelitian ini dilakukan untuk menganalisis popularitas empat destinasi wisata pulau di dunia yaitu Phuket, Bali, Hawaii, dan Langkawi. Metode penelitian: Penelitian ini menggunakan alat analisis statistik deskriptif dengan bantuan Google Trends untuk menentukan popularitas empat destinasi pulau tersebut. Hasil dan pembahasan: Analisis menunjukkan bahwa sejak awal tahun 2000 hingga akhir tahun 2021, destinasi Phuket sangat populer bagi wisatawan yang berasal dari Thailand sendiri, Russia, Turkey, Hong Kong, dan Singapore. Bali sangat populer di kalangan wisatawan Indonesia sendiri, Netherlands, India, Australia, dan Belgium. Hawaii sangat populer di kalangan wisatawan dari United States sendiri, Japan, Canada, Brazil, dan South Korea. Langkawi sangat populer di kalangan wisatawan yang berasal dari Malaysia sendiri, Singapore, Pakistan, Hong Kong, dan Egypt. Implikasi: Destinasi wisata yang paling populer adalah Hawaii, kemudian Bali, lalu Phuket, dan yang terakhir adalah Langkawi. Bali menduduki posisi kedua atau setelah Hawaii

Strategi Pembelajaran Berbasisi Digital: Berbagai Bidang Ilmu Pengetahuan

Sistematika buku ini dengan judul “Strategi Pembelajaran Berbasis Digital: Berbagai Bidang Pengetahuan” terdiri atas 13 bab yang dijelaskan secara rinci dalam pembahasan mengenai konsep dan strategi dan implementasinya diantaranya: Strategi Pembelajaran Digital pada PAUD, SD, Ilmu Pengetahuan Alam SMP, Bahasa Ingris smp, Matematika smp, Bahasa Indonesia SMP, Ilmu Pengetahuan Sosial SMP, Bahasa Indonesia SMA, Bahasa Inggris SMA, Fisika SMA, Biologi SMA, Kimia SMA, IPS SM

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease. Mice that underwent transverse aortic constriction and calcineurin transgenic (Tg) mice, both models of experimental heart failure, displayed a significant increase in cardiac expression of fetal isoform CHAPb. To investigate whether increased expression of CHAPb postnatally is sufficient to induce cardiomyopathy, we generated CHAPb Tg mice under the control of the cardiac-specific αMHC promoter. CHAPb Tg mice displayed cardiac hypertrophy, interstitial fibrosis and enlargement of the left atrium at three months, which was more pronounced at the age of six months. Hypertrophy and fibrosis were confirmed by evidence of activation of the hypertrophic gene program (Nppa, Nppb, Myh7) and increased collagen expression, respectively. Connexin40 and 43 were downregulated in the left atrium, which was associated with delayed atrioventricular conduction. Tg hearts displayed both systolic and diastolic dysfunction partly caused by impaired sarcomere function evident from a reduced force generating capacity of single cardiomyocytes. This co-incided with activation of the actin signalling pathway leading to the formation of stress fibers. This study demonstrated that the fetal isoform CHAPb initiates progression towards cardiac hypertrophy, which is accompanied by delayed atrioventricular conduction and diastolic dysfunction. Moreover, CHAP may be a novel therapeutic target or candidate gene for screening in cardiomyopathies and atrial fibrillatio