34 research outputs found
Expanded Sampling Across Ontogeny in <I>Deltasuchus motherali</I> (Neosuchia, Crocodyliformes)
A revised diagnosis of this species, describing the new material and discussing incidents of apparent ontogenetic variation across the sampled population. The results of the ensuing phylogenetic analyses both situate Deltasuchus within an endemic clade of Appalachian crocodyliforms, separate and diagnosable from goniopholidids and pholidosaurs. This title is also available as Open Access on Cambridge Core
Increasing Number of Unusual Brain Abnormalities Seen in Rural West Virginia
The incidence rate of schizencephaly is 1.5 in 100,000 live births and the rate of holoprosencephaly is 1 in 16,000 live births. Both malformations are rare, but our institution has seen a dramatic increase in both malformations in recent years with no known cause. Schizencephaly is the most severe cortical malformation and holoprosencephaly is the most common defect in the prosencephalon during development however, it is still not very common to see a fetus with this defect live to delivery. Our institution seen four cases of schizencephaly and three cases of holoprosencephaly within two years. No two neonates seem to share a common factor. All had different co-morbidities and presentations, all mothers were different ages and showed few risk factors if any for these deformities. This paper is a report of the cases found of these rare birth defects seen at our institution in recent years
Increased Soft Palate Angle and Basihyoid depth is related to increased Body Condition Score and increased Tongue Size in the Horse
Volume 05
Introduction from Dean Dr. Charles Ross
The Tallis House as an Extension of Emily Tallis in McEwan\u27s Atonement by Ian Karamarkovich
Graphic Design by Jessica Cox
Graphic Design by Kyle Fowlkes
Graphic Design by Allison Pawlowski
Incorporating Original Research in The Classroom: A Case Study Analyzing the Influence of the Chesapeake Bay on Local Temperatures by Kaitlin Major, Carrie Dunham and Dr. Kelsey Scheitlin
Graphic Design by Kathryn Grayson
Graphic Design by Ashley Johnson
Facing the Music: Environmental Impact Assessment of Building A Concert Hall on North Campus by Jennifer Nehrt, Kelsey Stolzenbach And Dr. Kelsey Scheitlin
Art by Kristin McQuarrie
Art by Sara Nelson
Art by Melisa Michelle
Prosocial Behavior as a Result of Prosocial Music by Jessica Sudlow
Graphic Design by Perry Bason
Graphic Design by Danielle Dmuchawski
Graphic Design by Mariah Asbell
Graphic Design by Matthew Sakach
Identifying Pathogenic Salmonella Serotypes Isolated from Prince Edward County, VA Waterways via Mutiplex PCR Analysis by Timothy Smith, Jr.
Art by Annaliese Troxell
Art by T. Dane Summerell
Development of Salicylidene Anilines for Application in the High School Laboratory by Sarah Ganrude
Graphic Design by Malina Rutherford
Graphic Design by Hannah Hopper, and Matthew Sakach
Because That\u27s What Daddies Do: Effects of Fathering Patterns on Son\u27s Self and Gender Identities by John Berry, Jr.
Graphic Design by James Early
Graphic Design by Colleen Festa
The Influence of Tropical Cyclones on Chesapeake Bay Dead Zones by Chelsea D. Taylor and Dr. Kelsey Scheitlin
Graphic Design by Michelle Maddox
Graphic Design by Kaitlyn Smith
Graphic Design by Sarah Schu
Graphic Design by Perry Bason, Cabell Edmunds, Katherine Grayson, Matthew Sakach, and Kayla Torna
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit
Maternal Smoking and Offspring Risk for Developing Obesity
Research demonstrates that maternal tobacco smoke exposure during fetal development increases the offspring\u27s risk for developing obesity and type II diabetes in adulthood. Many pregnant women continue to smoke throughout pregnancy and nursing, and this project aimed to identify mechanisms that play a role in this increased risk of disease. We hypothesized that primary fibroblasts from offspring exposed to tobacco smoke in utero will have increased susceptibility to differentiate into adipocytes compared to cells from offspring born to nonsmokers. Human neonatal tissue was collected from babies born to smoking and nonsmoking mothers (n=9/group). Cells from babies born to smoking mothers displayed significantly increased levels of mRNA markers of adipocyte differentiation (fatty acid binding protein 4, forkhead box protein O1, and fatty acid transport protein 4) compared to cells collected from babies of non-smoking mothers (p \u3c 0.05). Thus, we demonstrate for the first time in neonatal tissue that maternal smoke exposure increases adipocyte differentiation in primary fibroblasts of offspring
Accuracy of radiographic diagnosis of pneumoperitoneum secondary to gastrointestinal perforation in dogs and cats
Long-Term Dataset of Tidal Residuals in New South Wales, Australia
Continuous water level records are required to detect long-term trends and analyse the climatological mechanisms responsible for extreme events. This paper compiles nine ocean water level records from gauges located along the New South Wales (NSW) coast of Australia. These gauges represent the longest and most complete records of hourly—and in five cases 15-min—water level data for this region. The datasets were adjusted to the vertical Australian Height Datum (AHD) and had the rainfall-related peaks removed from the records. The Unified Tidal Analysis and Prediction (Utide) model was subsequently used to predict tides for datasets with at least 25 years of records to obtain the associated tidal residuals. Finally, we provide a series of examples of how this dataset can be used to analyse trends in tidal anomalies as well as extreme events and their causal processes