The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels

There is now overwhelming evidence for Epoxyeicosatrienoic acids (EETs) as endothelial derived hyperpolarising factor (EDHF). Most recently, a number of pharmacological tools have been developed for the study of EETs in relation to EDHF responses. EETs have been shown to cause relaxation by activating smooth muscle large conductance Ca2+ sensitive K+ (BKCa) (Archer et al, 2003). This dilatory response has been shown to be specifically inhibited by its analogue 14, 15-epoxyeicosa-5 (Z) enoic acid (14, 15 EEZE) in both human internal mammary artery and bovine coronary artery (Archer et al, 2003). Here we have investigated the antagonist effects of 14, 15 EEZE in murine arteries. Male Black 6 mice (12-18 weeks) were killed by lethal exposure to CO2. First order arteries were isolated and mounted in wire myographs immersed in physiological salt solution (PSS). Arteries were equilibrated (30 mins) and tensions normalised as described previously (Mulvany and Halpern, 1977). Arteries incubated for 30 minutes with or without 3µg/ml 14, 15 EEZE. A concentration response curve to 11, 12 EET was performed cumulatively on arteries pre-contracted with EC80 U46619. In some experiments, arteries were pre-contracted with EC80 U46619, and concentration response to 14, 15 EEZE performed cumulatively.Non peer reviewe

Pressure study of nematicity and quantum criticality in Sr3_3Ru2_2O7_7 for an in-plane field

We study the relationship between the nematic phases of Sr$_3$Ru$_2$O$_7$ and quantum criticality. At ambient pressure, one nematic phase is associated with a metamagnetic quantum critical end point (QCEP) when the applied magnetic field is near the \textit{c}-axis. We show, however, that this metamagnetic transition does not produce the same nematic signatures when the QCEP is reached by hydrostatic pressure with the field applied in the \textit{ab}-plane. Moreover, a second nematic phase, that is seen for field applied in the \textit{ab}-plane close to, but not right at, a second metamagnetic anomaly, persists with minimal change to the highest applied pressure, 16.55 kbar. Taken together our results suggest that metamagnetic quantum criticality may not be necessary for the formation of a nematic phase in Sr$_3$Ru$_2$O$_7$

Validity of the Adiabatic Approximation

We analyze the validity of the adiabatic approximation, and in particular the reliability of what has been called the "standard criterion" for validity of this approximation. Recently, this criterion has been found to be insufficient. We will argue that the criterion is sufficient only when it agrees with the intuitive notion of slowness of evolution of the Hamiltonian. However, it can be insufficient in cases where the Hamiltonian varies rapidly but only by a small amount. We also emphasize the distinction between the adiabatic {\em theorem} and the adiabatic {\em approximation}, two quite different although closely related ideas.Comment: 4 pages, 1 figur

A new perturbative approach to the adiabatic approximation

A new and intuitive perturbative approach to time-dependent quantum mechanics problems is presented, which is useful in situations where the evolution of the Hamiltonian is slow. The state of a system which starts in an instantaneous eigenstate of the initial Hamiltonian is written as a power series which has a straightforward diagrammatic representation. Each term of the series corresponds to a sequence of "adiabatic" evolutions, during which the system remains in an instantaneous eigenstate of the Hamiltonian, punctuated by transitions from one state to another. The first term of this series is the standard adiabatic evolution, the next is the well-known first correction to it, and subsequent terms can be written down essentially by inspection. Although the final result is perhaps not terribly surprising, it seems to be not widely known, and the interpretation is new, as far as we know. Application of the method to the adiabatic approximation is given, and some discussion of the validity of this approximation is presented.Comment: 9 pages. Added references, discussion of previous results, expanded upon discussion of main result and application of i

Detailed Topography of the Fermi Surface of Sr2RuO4

We apply a novel analysis of the field and angle dependence of the quantum-oscillatory amplitudes in the unconventional superconductor Sr2RuO4 to map its Fermi surface in unprecedented detail, and to obtain previously inaccessible information on the band dispersion. The three quasi-2D Fermi surface sheets not only exhibit very diverse magnitudes of warping, but also entirely different dominant warping symmetries. We use the data to reassess recent results on c-axis transport phenomena.Comment: REVTeX, 4 page

Maxwell-Chern-Simons Q-balls

We examine the energetics of $Q$-balls in Maxwell-Chern-Simons theory in two space dimensions. Whereas gauged $Q$-balls are unallowed in this dimension in the absence of a Chern-Simons term due to a divergent electromagnetic energy, the addition of a Chern-Simons term introduces a gauge field mass and renders finite the otherwise-divergent electromagnetic energy of the $Q$-ball. Similar to the case of gauged $Q$-balls, Maxwell-Chern-Simons $Q$-balls have a maximal charge. The properties of these solitons are studied as a function of the parameters of the model considered, using a numerical technique known as relaxation. The results are compared to expectations based on qualitative arguments.Comment: 6 pages. Talk given at Theory CANADA 2, Perimeter Institut

Non-Singular Stationary Global Strings

A field-theoretical model for non-singular global cosmic strings is presented. The model is a non-linear sigma model with a potential term for a self-gravitating complex scalar field. Non-singular stationary solutions with angular momentum and possibly linear momentum are obtained by assuming an oscillatory dependence of the scalar field on t, phi and z. This dependence has an effect similar to gauging the global U(1) symmetry of the model, which is actually a Kaluza-Klein reduction from four to three spacetime dimensions. The method of analysis can be regarded as an extension of the gravito-electromagnetism formalism beyond the weak field limit. Some D=3 self-dual solutions are also discussed.Comment: 20 pages Latex, 12 PS figures included. Minor corrections. Version to appear in Phys.Rev.

Rigid-Band Shift of the Fermi Level in a Strongly Correlated Metal: Sr(2-y)La(y)RuO(4)

We report a systematic study of electron doping of Sr2RuO4 by non-isovalent substitution of La^(3+) for Sr^(2+). Using a combination of de Haas-van Alphen oscillations, specific heat, and resistivity measurements, we show that electron doping leads to a rigid-band shift of the Fermi level corresponding to one doped electron per La ion, with constant many-body quasiparticle mass enhancement over the band mass. The susceptibility spectrum is substantially altered and enhanced by the doping but this has surprisingly little effect on the strength of the unconventional superconducting pairing.Comment: 4 pages, 3 figure