Das Bauhaus vor dem Hintergrund sozialökonomischer Strukturen und politischer Kräftegruppierungen in Dessau 1925 bis 1930

Wissenschaftliches Kolloquium vom 27. bis 29. Oktober 1976 in Weimar an der Hochschule für Architektur und Bauwesen zum Thema: '50 Jahre Bauhaus Dessau

Fibroblastenbasierter VEGF-Gentransfer zur experimentellen Präfabrikation myocutaner Transplantate: Untersuchung des Einflusses des Applikationszeitpunktes auf die VEGF induzierte Neoangiogenese

Die Ergebnisse meiner experimentellen Forschung belegen einen pro - angiogeneti-schen und pro - arteriogenetischen Effekt der VEGF transfektierten Fibroblasten. Da-bei wurde die Neovaskularisation sowohl in der Haut als auch im Muskel initiiert. Der Zeitraum zwischen Injektion der transfektierten Fibroblasten und Ligation der versor-genden Arterie hat keinen Einfluss auf die Neovaskularisation. Nach der Ligation ist davon auszugehen, dass in der Haut am dritten Tag und im Muskel nach zwei Wochen die meisten Gefäße vorkommen

Das Bauhaus vor dem Hintergrund sozialökonomischer Strukturen und politischer Kräftegruppierungen in Dessau 1925 bis 1930

Wissenschaftliches Kolloquium vom 27. bis 29. Oktober 1976 in Weimar an der Hochschule für Architektur und Bauwesen zum Thema: '50 Jahre Bauhaus Dessau

A Life-course Analysis of Gene-Environment Interplay in Schizophrenia and Major Depression

Background: Although genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) are well established, it is not clear whether the exposure to these environmental risks is genetically confounded through a mechanism known as gene- environment correlation (rGE). Identifying whether rGE is implicated in the aetiology of these two psychiatric disorders may help our understanding of how to treat or prevent psychopathologies. Objective: This thesis aimed to investigate whether known environmental risk factors are correlated with the genetic susceptibilities to SCZ/MDD across three British community cohorts in childhood, adulthood and across the different developmental periods over time. We also wished to compare findings from a systematic literature review of empirical rGE studies for SCZ and depression to our own results. Methods: Polygenic risk scores (PRS), which were derived from existing genome-wide associations studies (GWAS), were utilised to investigate the correlation between known environmental risk factors and the genetic liability to SCZ/MDD. For the systematic literature review we searched seven databases for publications reporting rGE for either psychopathology in participants of any age. Results: We found associations between the genetic risk for SCZ and several psychosocial risk factors, such as marital status, whilst the genetic susceptibility to MDD was more strongly correlated with indicators of adverse socio-economic status across childhood and adulthood. Overall, the majority of rGE correlations remained stable across the investigated developmental periods. In contrast to our own results, rGE associations for SCZ and depression which were identified in the systematic literature review were largely the same across the included articles. Conclusion: In summary, our findings propose that several known psychosocial and environmental risk factors for either SCZ or MDD are at least partially correlated with the genetic liability for these psychopathologies in childhood as well as adulthood

Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples

Schizophrenia (SCZ) and major depressive disorder (MDD) are complex psychiatric disorders which contribute substantially to the global burden of disease. Both psychopathologies are heritable with some genetic overlap between them. Importantly, SCZ and MDD have also been found to be associated with environmental risk factors. However, rather than being independent of genetic influences, exposure to environmental risk factors may be under genetic control, known as gene-environment correlation (rGE). In this study we investigated rGE in relation to polygenic risk scores for SCZ and MDD in adults, derived from large genome-wide association studies, across two different British community samples: Understanding Society (USoc) and the National Child Development Study (NCDS). We tested whether established environmental risk factors for SCZ and/or MDD are correlated with polygenic scores in adults and whether these associations differ between the two disorders and cohorts. Findings partially overlapped between disorders and cohorts. In NCDS, we identified a significant correlation between the genetic risk for MDD and an indicator of low socio-economic status, but no significant findings emerged for SCZ. In USoc, we replicated associations between indicators of low socio-economic status and the genetic propensity for MDD. In addition, we identified associations between the genetic susceptibility for SCZ and being single or divorced. Results across both studies provide further evidence that the genetic risk for SCZ and MDD were associated with common environmental risk factors, specifically MDD’s association with lower socio-economic status

The role of different directions of attention on the extent of implicit perception in soccer penalty kicking

The role of different directions of attention on the extent of the off-center effect (penalty takers kick to the bigger side of the goal more often, although they explicitly perceive the goalkeeper in the center of the goal) was investigated for soccer penalty kicking. Regarding the directions of attention of the striker, two conflicting assumptions (attention is paid to the goalkeeper vs. attention is only spent on target) were directly contrasted. Participants viewed a goalkeeper standing either in the middle of the goal or being displaced by different distances to the left or right. In the goal-side-related instruction condition, participants had to indicate the greater goal side and already did so at above chance-level for small displacements of 0.1%, although they were not confident in their perceptual judgments, hinting at the occurrence of the off-center effect. They became mindful of displacements of 0.8% and larger when they indicated the goal side for kicking with greater confidence. In the goalkeeper-related instruction condition, participants were asked to choose a goal side for kicking, but only when they perceived the goalkeeper in the middle of the goal. Participants chose the greater goal side at above chance-level for small displacements of 0.2%. They became mindful of the displacement for a difference of 0.8%. However, when comparing the results of both instruction conditions statistically it turned out that the effect of different directions of attention on the off-center's extent differs from those previously reported. Participants were implicitly influenced by comparably small goalkeeper displacements, but became earlier aware of goalkeeper displacements in the goal-side-related instruction condition

Letter to the Editor. Fetal thymus and the 22q11.2 deletion

No abstract