7-Selenabicyclo2.2.1heptane

Thermolysis of a benzene solution of N-4-(p-(methoxybenzyl)seleno) cyclohexanoyl-N,S-dimethyldithiocarbonate affords the hitherto unknown 7-selenabicyclo2.2.1heptane in 48% conversion and in 20% yield after chromatography. G3(MP2)-RAD calculations predict a rate constant of 5 X 104 s-1 at 80 °C (3.8 X 106 s -1 at 200 °C) for the intramolecular homolytic substitution process involved in this cyclization

Fluorescent Angiotensin AT₁ Receptor Antagonists

Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed